About: Neutrophil extracellular traps and thrombosis in COVID-19

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Neutrophil extracellular traps and thrombosis in COVID-19
Creator	Shi, Hui Gockman, Kelsey Kanthi, Yogendra Knight, Jason Madison, Jacqueline Yalavarthi, Srilakshmi Zuo, Melanie Zuo, Yu
Source	MedRxiv; Medline
abstract	Here, we report on four patients whose hospitalizations for COVID-19 were complicated by venous thromboembolism (VTE). All demonstrated high levels of D-dimer as well as high neutrophil-to-lymphocyte ratios. For three patients, we were able to test sera for neutrophil extracellular trap (NET) remnants and found significantly elevated levels of cell-free DNA, myeloperoxidase-DNA complexes, and citrullinated histone H3. Neutrophil-derived S100A8/A9 (calprotectin) was also elevated. Given strong links between hyperactive neutrophils, NET release, and thrombosis in many inflammatory diseases, the potential relationship between NETs and VTE should be further investigated in COVID-19.
has issue date	2020-05-05(xsd:dateTime)
bibo:doi	10.1101/2020.04.30.20086736
bibo:pmid	32511553
has license	medrxiv
sha1sum (hex)	109ca563e82920a33fea13c1080ae969c0109df8
schema:url	https://doi.org/10.1101/2020.04.30.20086736
resource representing a document's title	Neutrophil extracellular traps and thrombosis in COVID-19
has PubMed identifier	32511553
schema:publication	medRxiv : the preprint server for health sciences
resource representing a document's body	covid:109ca563e82920a33fea13c1080ae969c0109df8#body_text
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