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About:
Vaporized H2O2 decontamination against surrogate viruses for the reuse of N95 respirators in the COVID-19 emergency
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wasabi.inria.fr
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Type:
Academic Article
research paper
schema:ScholarlyArticle
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type
Academic Article
research paper
schema:ScholarlyArticle
isDefinedBy
Covid-on-the-Web dataset
has title
Vaporized H2O2 decontamination against surrogate viruses for the reuse of N95 respirators in the COVID-19 emergency
Creator
Budzilowicz, Amanda
Collins, Cassidy
Connolly, Rachel
Durkin, John
Gardecki, Joseph
Gjore, Julian
Jaber, Tareq
Jones, Ralph
Leung, Hui
Muratoglu, Orhun
Oral, Ebru
Wannomae, Keith
Source
MedRxiv
abstract
Decontamination of N95 respirators has become critical to alleviate PPE shortages for healthcare workers in the current COVID-19 emergency. The factors that are considered for the effective reuse of these masks are the fit, filter efficiency and decontamination/disinfection level both for SARS-CoV-2, which is the causative virus for COVID-19, and for other organisms of concern in the hospital environment such as Staphylococcus aureus or Clostridium difficile. In its guidance entitled 'Recommendations for Sponsors Requesting EUAs for Decontamination and Bioburden Reduction Systems for Surgical Masks and Respirators During the Coronavirus Disease 2019 (COVID19) Public Health Emergency' (May 2020)[1], the FDA recommends a 6-log10 reduction in either the most resistant bacterial spores for the system or in a mycobacterium species to authorize the use of a decontamination method of N95 respirators for single or multiple users. While the goal is primarily inactivation against SARS-CoV-2, testing of decontamination methods against the virus may not always be available. For decontamination methods considered for only single users, the recommendation is a 6-log10 reduction in the infective virus concentration of 3 non-enveloped viruses or in the concentration of two Gram (+) and two Gram (-) bacteria. Based on these recommendations, we explored the efficacy of vaporized H2O2 (VHP) treatment of N95 respirators against surrogate viruses covering a wide range of disinfection resistance for emergency decontamination and reuse to alleviate PPE shortages for healthcare workers in the COVID-19 emergency.
has issue date
2020-06-28
(
xsd:dateTime
)
bibo:doi
10.1101/2020.06.25.20140269
has license
medrxiv
sha1sum (hex)
10fd1ed5e9e4ee5ad39270ed5c09c91469ec41fb
schema:url
https://doi.org/10.1101/2020.06.25.20140269
resource representing a document's title
Vaporized H2O2 decontamination against surrogate viruses for the reuse of N95 respirators in the COVID-19 emergency
resource representing a document's body
covid:10fd1ed5e9e4ee5ad39270ed5c09c91469ec41fb#body_text
is
schema:about
of
named entity 'COVID-19'
named entity 'respirators'
named entity 'SURROGATE'
named entity 'Clostridium'
named entity 'PPE'
named entity 'hospital'
named entity 'decontamination'
named entity 'reuse'
named entity 'disinfection'
named entity 'Staphylococcus aureus'
named entity 'Decontamination'
named entity 'COVID'
named entity 'Clostridium difficile'
named entity 'virus'
named entity 'cytotoxic'
named entity 'Needham Heights'
named entity 'disinfection'
named entity 'disinfection'
named entity 'bioburden'
named entity 'viruses'
named entity 'biosafety cabinet'
named entity 'biosafety cabinet'
named entity 'titer'
named entity 'cell culture medium'
named entity 'infectivity'
named entity 'cell culture medium'
named entity 'bioburden'
named entity 'cytotoxic'
named entity 'respirator'
named entity 'cell line'
named entity 'cell culture media'
named entity 'centrifugation'
named entity 'respirator'
named entity 'virus'
named entity 'Steris'
named entity 'FDA'
named entity 'BVDV'
named entity 'virus'
named entity 'RPMI'
named entity 'preprint'
named entity 'BVDV'
named entity 'viral titers'
named entity 'cell culture medium'
named entity 'EUAs'
named entity 'preprint'
named entity 'VHP'
named entity 'virus'
named entity 'virus'
named entity 'BVDV'
named entity 'Bacterial spore'
named entity 'Public Health Emergency'
named entity 'Surgical Masks'
named entity 'FDA'
named entity 'African green monkey kidney cells'
named entity 'sterilization'
named entity 'bacterial spores'
named entity 'virus'
named entity 'MDCK'
named entity 'virus'
named entity 'viruses'
named entity 'N95'
named entity 'virus'
named entity 'N95'
named entity 'biological safety cabinet'
named entity 'RNA viruses'
named entity 'medRxiv'
named entity 'microtiter plates'
named entity 'virus'
named entity 'virus'
named entity 'C. difficile'
named entity 'COVID-19'
named entity 'respirator'
named entity 'virus'
named entity 'virus'
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