About: Innate Immunity and Pathogenesis of Biliary Atresia

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About: Innate Immunity and Pathogenesis of Biliary Atresia Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Innate Immunity and Pathogenesis of Biliary Atresia
Creator	Donnelly, Bryan Tiao, Greg Bansal, Ruchi Ortiz-Perez, Ana Temple, Haley Mohanty, Sujit Herrmann, Martin Bansal, Kushagra Kumar Mohanty, Sujit
Source	Medline; PMC
abstract	Biliary atresia (BA) is a devastating fibro-inflammatory disease characterized by the obstruction of extrahepatic and intrahepatic bile ducts in infants that can have fatal consequences, when not treated in a timely manner. It is the most common indication of pediatric liver transplantation worldwide and the development of new therapies, to alleviate the need of surgical intervention, has been hindered due to its complexity and lack of understanding of the disease pathogenesis. For that reason, significant efforts have been made toward the development of experimental models and strategies to understand the etiology and disease mechanisms and to identify novel therapeutic targets. The only characterized model of BA, using a Rhesus Rotavirus Type A infection of newborn BALB/c mice, has enabled the identification of key cellular and molecular targets involved in epithelial injury and duct obstruction. However, the establishment of an unleashed chronic inflammation followed by a progressive pathological wound healing process remains poorly understood. Like T cells, macrophages can adopt different functional programs [pro-inflammatory (M1) and resolutive (M2) macrophages] and influence the surrounding cytokine environment and the cell response to injury. In this review, we provide an overview of the immunopathogenesis of BA, discuss the implication of innate immunity in the disease pathogenesis and highlight their suitability as therapeutic targets.
has issue date	2020-02-25(xsd:dateTime)
bibo:doi	10.3389/fimmu.2020.00329
bibo:pmid	32161597
has license	cc-by
sha1sum (hex)	10fd473d3d99f0ac86c9c0d920d6a9e5738c843e
schema:url	https://doi.org/10.3389/fimmu.2020.00329
resource representing a document's title	Innate Immunity and Pathogenesis of Biliary Atresia
has PubMed Central identifier	PMC7052372
has PubMed identifier	32161597
schema:publication	Front Immunol
resource representing a document's body	covid:10fd473d3d99f0ac86c9c0d920d6a9e5738c843e#body_text
is schema:about of	named entity 'Biliary atresia' named entity 'highlight' named entity 'mice' named entity 'newborn' named entity 'Biliary' named entity 'INNATE IMMUNITY' named entity 'DUE TO' named entity 'ADOPT' named entity 'TYPE A' named entity 'INDICATION OF' named entity 'CELLULAR' named entity 'BILIARY ATRESIA' named entity 'PROVIDE' named entity 'POORLY' named entity 'CHRONIC INFLAMMATION' named entity 'T CELLS' named entity 'NOT TREATED' named entity 'TARGETS' named entity 'IDENTIFICATION' named entity 'INJURY' named entity 'REASON' named entity 'EPITHELIAL' named entity 'FATAL' named entity 'DEVELOPMENT' named entity 'CELL RESPONSE' named entity 'TO IDENTIFY' named entity 'INFLAMMATORY DISEASE' named entity 'PATHOGENESIS' named entity 'EXTRAHEPATIC' named entity 'WORLDWIDE' named entity 'LACK' named entity 'MACROPHAGES' named entity 'BALB' named entity 'BILE DUCTS' named entity 'REVIEW' named entity 'OVERVIEW' named entity 'INFECTION' named entity 'STRATEGIES' named entity 'LIKE' named entity 'ESTABLISHMENT' named entity 'ENABLED' named entity 'INTRAHEPATIC' named entity 'IMMUNOPATHOGENESIS' named entity 'THE CELL' named entity 'THERAPIES' named entity 'ENVIRONMENT' named entity 'PATHOGENESIS' named entity 'DISEASE' named entity 'INFANTS' named entity 'INFLUENCE' named entity 'KEY' named entity 'INVOLVED' named entity 'PROCESS' named entity 'RESPONSE TO' named entity 'FOLLOWED BY' named entity 'CONSEQUENCES' named entity 'OBSTRUCTION' named entity 'COMMON' named entity 'PROGRAMS' named entity 'RHESUS' named entity 'TIMELY' named entity 'MOLECULAR' named entity 'UNDERSTANDING' named entity 'USING' named entity 'SURGICAL INTERVENTION' named entity 'NOVEL' named entity 'INFLAMMATORY' named entity 'SURROUNDING' named entity 'HAVE' named entity 'CHARACTERIZED' named entity 'THERAPEUTIC' named entity 'NEW' named entity 'NEED'

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