About: Co-stimulation: novel methods for preventing viral-induced lung inflammation

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Co-stimulation: novel methods for preventing viral-induced lung inflammation
Creator	Hussell, Tracy Snelgrove, Robert Williams, Andrew Humphreys, Ian
Source	Elsevier; Medline; PMC
abstract	Respiratory infections cause significant morbidity and mortality worldwide. Although an immune response is required to eliminate respiratory pathogens, if unchecked, it can damage surrounding tissues and block primary lung function. Based on our knowledge of immune T-cell activation, there are several pathways to which immune intervention could be applied. However, relatively few interventions target only those immune cells that are responding to antigens. OX40 and 4-1BB are members of the tumour necrosis factor receptor family and are expressed on the surface of T cells in several inflammatory conditions. Recently, the inhibition of OX40 has proved beneficial during influenza virus infection. This review highlights the recent advances in the manipulation of such molecules and how they have been applied to inflammatory conditions that are caused by viruses in the lung.
has issue date	2004-08-01(xsd:dateTime)
bibo:doi	10.1016/j.molmed.2004.06.006
bibo:pmid	15310458
has license	els-covid
sha1sum (hex)	110a079d80d6985ea3164342d2c26aa5edc57833
schema:url	https://doi.org/10.1016/j.molmed.2004.06.006
resource representing a document's title	Co-stimulation: novel methods for preventing viral-induced lung inflammation
has PubMed Central identifier	PMC7185809
has PubMed identifier	15310458
schema:publication	Trends in Molecular Medicine
resource representing a document's body	covid:110a079d80d6985ea3164342d2c26aa5edc57833#body_text
is schema:about of	named entity 'Co-stimulation' named entity 'PREVENTING' named entity 'LUNG INFLAMMATION' named entity 'INDUCED' named entity 'VIRAL-' named entity 'METHODS' named entity 'NOVEL' named entity 'CO-STIMULATION' named entity 'mice' named entity 'OX40' named entity '4-1BB' named entity 'lipopolysaccharide' named entity '4-1BB' named entity 'autoimmune conditions' named entity 'CD27' named entity 'secondary lymphoid tissue' named entity 'ligands' named entity 'CD27' named entity 'influenza' named entity 'T-cell' named entity 'influenza virus' named entity '4-1BB' named entity 'co-stimulatory molecule' named entity 'co-stimulatory' named entity 'co-stimulatory signals' named entity 'cytokine' named entity 'OX40' named entity 'lymph nodes' named entity 'antigen' named entity 'PDL-1' named entity 'cytokines' named entity 'OX40' named entity 'N-terminal kinase' named entity 'clinical symptoms' named entity 'infection' named entity 'immune response' named entity 'immune mechanisms' named entity 'chemokines' named entity 'microenvironment' named entity 'programmed cell death' named entity 'CTLA-4' named entity 'IL-10' named entity 'cytokines' named entity 'CD4' named entity 'CD8' named entity '4-1BB' named entity 'co-stimulatory molecules' named entity 'inflammation' named entity 'lymphocytes' named entity 'TRAF5' named entity 'immunoglobulin (Ig) superfamily' named entity 'T-cell' named entity 'bronchi' named entity 'infection' named entity 'ligands' named entity 'inflammatory responses' named entity '4-1BB' named entity 'co-stimulatory molecules' named entity 'co-stimulatory signals' named entity 'respiratory syncytial virus' named entity 'T-cell' named entity 'respiratory infection' named entity 'T-cell' named entity 'ligand' named entity 'Intranasal' named entity '4-1BB' named entity 'CD28' named entity 'viruses' named entity 'T-cell' named entity 'antigens' named entity 'vaccine' named entity 'knockout mice' named entity 'co-stimulatory signals' named entity 'lymphocytes' named entity 'virus' named entity 'fusion proteins' named entity 'T-cell' named entity 'viruses'

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