About: Local delivery of siRNA-loaded calcium phosphate nanoparticles abates pulmonary inflammation

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Local delivery of siRNA-loaded calcium phosphate nanoparticles abates pulmonary inflammation
Creator	Bruder, Dunja Buer, Jan Epple, Matthias Frede, Annika Hansen, Wiebke Klopfleisch, Robert Knuschke, Torben Kollenda, Sebastian Neuhaus, Bernhard Westendorf, Astrid Wadwa,
Source	Elsevier; Medline; PMC
abstract	The local interference of cytokine signaling mediated by siRNA-loaded nanoparticles might be a promising new therapeutic approach to dampen inflammation during pulmonary diseases. For the local therapeutic treatment of pulmonary inflammation, we produced multi-shell nanoparticles consisting of a calcium phosphate core, coated with siRNAs directed against pro-inflammatory mediators, encapsulated into poly(lactic-co-glycolic acid), and coated with a final outer layer of polyethylenimine. Nasal instillation of nanoparticles loaded with a mixture of siRNAs directed against different cytokines to mice suffering from T(H)1 cell-mediated lung inflammation, or of siRNA directed against NS-1 in an influenza infection model led to a significant reduction of target gene expression which was accompanied by distinct amelioration of lung inflammation in both models. Thus, this study provides strong evidence that the specific and local modulation of the inflammatory response by CaP/PLGA nanoparticle-mediated siRNA delivery could be a promising approach for the treatment of inflammatory disorders of the lung.
has issue date	2017-08-08(xsd:dateTime)
bibo:doi	10.1016/j.nano.2017.08.001
bibo:pmid	28800875
has license	no-cc
sha1sum (hex)	110f20cdcecc8ba02f79f4b16cacefb9cc82709b
schema:url	https://doi.org/10.1016/j.nano.2017.08.001
resource representing a document's title	Local delivery of siRNA-loaded calcium phosphate nanoparticles abates pulmonary inflammation
has PubMed Central identifier	PMC7106047
has PubMed identifier	28800875
schema:publication	Nanomedicine
resource representing a document's body	covid:110f20cdcecc8ba02f79f4b16cacefb9cc82709b#body_text
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