About: Viral-induced suppression of self-reactive T cells: Lessons from neurotropic coronavirus-induced demyelination

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About: Viral-induced suppression of self-reactive T cells: Lessons from neurotropic coronavirus-induced demyelination Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Viral-induced suppression of self-reactive T cells: Lessons from neurotropic coronavirus-induced demyelination
Creator	Savarin, Carine Bergmann, Cornelia
topic	covid:116f9822d2121c96bfde4505b7e5e6c44ae0f63c#this
source	Elsevier; Medline; PMC
abstract	Abstract Genetic and environmental factors, i.e. infections, have been proposed to contribute to disease induction and relapsing events in multiple sclerosis (MS), an autoimmune demyelinating disease of the central nervous system (CNS). While research has mainly focused on virus associated autoimmune activation, less is known about prevention of autoimmunity, especially following resolving infections associated with CNS tissue damage. This review discusses novel insights on control of self-reactive (SR) T cells activated during neurotropic coronavirus-induced demyelination. A new concept is introduced that SR T cells can be dampened by distinct regulatory mechanisms in the periphery and the CNS, thereby preventing autoimmune disease.
has issue date	2017-07-15(xsd:dateTime)
bibo:doi	10.1016/j.jneuroim.2017.01.003
bibo:pmid	28108025
has license	els-covid
sha1sum (hex)	116f9822d2121c96bfde4505b7e5e6c44ae0f63c
schema:url	https://doi.org/10.1016/j.jneuroim.2017.01.003
resource representing a document's title	Viral-induced suppression of self-reactive T cells: Lessons from neurotropic coronavirus-induced demyelination
has PubMed Central identifier	PMC5474352
has PubMed identifier	28108025
schema:publication	Journal of Neuroimmunology
resource representing a document's body	covid:116f9822d2121c96bfde4505b7e5e6c44ae0f63c#body_text
is http://vocab.deri.ie/void#inDataset of	https://covidontheweb.inria.fr:4443/about/id/http/ns.inria.fr/covid19/116f9822d2121c96bfde4505b7e5e6c44ae0f63c
is schema:about of	named entity 'CORONAVIRUS' named entity 'virus' named entity 'This' named entity 'central nervous system (CNS)' named entity 'autoimmune' named entity 'infections' named entity 'AUTOIMMUNITY' named entity 'FOLLOWING' named entity 'NEUROTROPIC' named entity 'INFECTIONS' named entity 'SELF' named entity 'RESEARCH' named entity 'FOCUSED' named entity 'TISSUE DAMAGE' named entity 'EVENTS' named entity 'DEMYELINATION' named entity 'RELAPSING' named entity 'CONCEPT' named entity 'REGULATORY' named entity 'SUPPRESSION' named entity 'INDUCED' named entity 'KNOWN' named entity 'DISTINCT' named entity 'ASSOCIATED WITH' named entity 'ENVIRONMENTAL FACTORS' named entity 'PREVENTING' named entity 'GENETIC' named entity 'RESOLVING' named entity 'CENTRAL NERVOUS SYSTEM' named entity 'MECHANISMS' named entity 'DEMYELINATION' named entity 'NEUROTROPIC' named entity 'VIRAL-' named entity 'T CELLS' named entity 'INDUCTION' named entity 'INTRODUCED' named entity 'HAVE' named entity 'REACTIVE' named entity 'CONTRIBUTE ' named entity 'CNS' named entity 'NEW' named entity 'SELF' named entity 'REACTIVE' named entity 'MULTIPLE SCLEROSIS' named entity 'AUTOIMMUNE' named entity 'T CELLS' named entity 'ABOUT' named entity 'VIRUS ASSOCIATED' named entity 'INSIGHTS' named entity 'ACTIVATED' named entity 'ACTIVATION' named entity 'PREVENTION OF' named entity 'AUTOIMMUNE DEMYELINATING DISEASE' named entity 'REVIEW' named entity 'PROPOSED' named entity 'NOVEL' named entity 'AUTOIMMUNE DISEASE' named entity 'CONTROL' named entity 'PERIPHERY' named entity 'DISEASE' named entity 'CNS' named entity 'events' named entity 'demyelinating disease' named entity 'activated' named entity 'neurotropic' named entity 'resolving' named entity 'demyelination' named entity 'autoimmune disease' named entity 'demyelination' named entity 'CNS tissue' named entity 'CNS' named entity 'viral persistence' named entity 'myelin' named entity 'virus' named entity 'Tregs' named entity 'antigen' named entity 'anti-viral' named entity 'CD4'

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