About: Acute Kidney Injury in a Case Series of Patients with Confirmed COVID-19 (Coronavirus Disease 2019): Role of Angiotensin-Converting Enzyme 2 and Renin-Angiotensin System Blockade

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About: Acute Kidney Injury in a Case Series of Patients with Confirmed COVID-19 (Coronavirus Disease 2019): Role of Angiotensin-Converting Enzyme 2 and Renin-Angiotensin System Blockade Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Acute Kidney Injury in a Case Series of Patients with Confirmed COVID-19 (Coronavirus Disease 2019): Role of Angiotensin-Converting Enzyme 2 and Renin-Angiotensin System Blockade
Creator	Adapa, Sreedhar Bose, Subhasish Chenna, Avantika Gayam, Vijay Konala, Venu Madhira, Bhaskar Naramala, Srikanth Roy, Sasmit
Source	Medline; PMC
abstract	The renin-angiotensin system plays a very critical role in hypertension, diabetes, and kidney and heart diseases. The blockade of the renin-angiotensin system results in the prevention of progression of renal and cardiac damage. There have been controversial hypotheses raised regarding the safety of angiotensin-converting enzyme inhibitors and angiotensin receptor blockers in COVID-19 (coronavirus disease 2019). We present the case series of four patients (2 men and 2 women; 1 Caucasian and 3 African Americans; two survived and two died) with confirmed COVID-19, presenting with respiratory symptoms and acute kidney injury, who have been on angiotensin-converting enzyme inhibitors or angiotensin receptor blockers. Membrane-bound angiotensin-converting enzyme 2 (ACE2) has been implicated as the gateway for viral entry into the human cell in causing the infection. The factors contributing to acute kidney injury are diuretics, iodinated contrast administration, hemodynamic instability apart from ACE inhibitors, and angiotensin receptor blockers. The ACE inhibitors and ARBs were stopped in these patients due to acute kidney injury. We also discussed the role of ACE2 and the renin-angiotensin system (RAS) blockade in patients with COVID-19 infection along with pathogenesis.
has issue date	2020-06-29(xsd:dateTime)
bibo:doi	10.1155/2020/8811931
bibo:pmid	32685221
has license	cc-by
sha1sum (hex)	1177ea3523da00bd3801bd2e2bf26cb82ff65d72
schema:url	https://doi.org/10.1155/2020/8811931
resource representing a document's title	Acute Kidney Injury in a Case Series of Patients with Confirmed COVID-19 (Coronavirus Disease 2019): Role of Angiotensin-Converting Enzyme 2 and Renin-Angiotensin System Blockade
has PubMed Central identifier	PMC7341421
has PubMed identifier	32685221
schema:publication	Case Rep Nephrol
resource representing a document's body	covid:1177ea3523da00bd3801bd2e2bf26cb82ff65d72#body_text
is schema:about of	named entity 'blockers' named entity 'patients' named entity 'renin-angiotensin system' named entity 'ARBs' named entity 'gateway' named entity 'pathogenesis' named entity 'receptor' named entity 'confirmed' named entity 'Role' named entity 'RENAL' named entity 'RAISED' named entity 'HEMODYNAMIC INSTABILITY' named entity 'PATIENTS' named entity 'HEART DISEASES' named entity 'GATEWAY' named entity 'diuretics' named entity 'case series' named entity 'angiotensin' named entity 'cardiac damage' named entity 'symptoms' named entity 'instability' named entity 'ACE2' named entity 'renal' named entity 'receptor' named entity 'Confirmed' named entity 'renin-angiotensin' named entity 'RAS' named entity 'hypertension' named entity 'respiratory symptoms' named entity 'renin-angiotensin' named entity 'infection' named entity 'angiotensin receptor blockers' named entity 'viral entry' named entity 'heart diseases' named entity 'iodinated contrast' named entity 'acute kidney injury' named entity 'COVID' named entity 'COVID-19 infection' named entity 'diabetes' named entity 'angiotensin-converting enzyme inhibitors' named entity 'ACE inhibitors' named entity 'Renin-Angiotensin' named entity 'COVID-19' named entity 'protein' named entity 'AT1R' named entity 'lisinopril' named entity 'chest pain' named entity 'type 2 diabetes mellitus' named entity 'diarrhea' named entity 'respiratory failure' named entity 'ACE2' named entity 'prone position' named entity 'SARS-CoV-2' named entity 'hypothyroidism' named entity 'serum creatinine' named entity 'inflammation' named entity 'Lasix' named entity 'ACEI' named entity 'sputum' named entity 'Influenza' named entity 'hematuria' named entity 'fluid overload' named entity 'Urine analysis' named entity 'levothyroxine' named entity 'brush border' named entity 'aldosterone' named entity 'diabetes' named entity 'clinical studies' named entity 'HIV' named entity 'beats per minute' named entity 'H7N9' named entity 'hemodynamic' named entity 'receptor' named entity 'infection'

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