About: Engineering RNA for Targeted siRNA Delivery and Medical Application

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Engineering RNA for Targeted siRNA Delivery and Medical Application
Creator	Guo, Peixuan Guo, Songchuan Coban, Oana Hoeprich, Steve Shu, Yi Trebley, Joe Snead, Nicholas
Source	Elsevier; Medline; PMC
abstract	RNA engineering for nanotechnology and medical applications is an exciting emerging research field. RNA has intrinsically defined features on the nanometer scale and is a particularly interesting candidate for such applications due to its amazing diversity, flexibility and versatility in structure and function. Specifically, the current use of siRNA to silence target genes involved in disease has generated much excitement in the scientific community. The intrinsic ability to sequence-specifically down-regulate gene expression in a temporally- and spatially-controlled fashion has led to heightened interest and rapid development of siRNA-based therapeutics. Though methods for gene silencing with high efficacy and specificity have been achieved in vitro, the effective delivery of nucleic acids to specific cells in vivo has been a hurdle for RNA therapeutics. This review covers different RNA-based approaches for diagnosis, prevention and treatment of human disease, with a focus on the latest developments of nonviral carriers of siRNA for delivery in vivo. The applications and challenges of siRNA therapy, as well as potential solutions to these problems, the approaches for using phi29 pRNA-based vectors as polyvalent vehicles for specific delivery of siRNA, ribozymes, drugs or other therapeutic agents to specific cells for therapy will also be addressed.
has issue date	2010-04-01(xsd:dateTime)
bibo:doi	10.1016/j.addr.2010.03.008
bibo:pmid	20230868
has license	green-oa
sha1sum (hex)	118eb919e64fc55d82d5071ae893561a3f4af4b6
schema:url	https://doi.org/10.1016/j.addr.2010.03.008
resource representing a document's title	Engineering RNA for Targeted siRNA Delivery and Medical Application
has PubMed Central identifier	PMC2906696
has PubMed identifier	20230868
schema:publication	Advanced Drug Delivery Reviews
resource representing a document's body	covid:118eb919e64fc55d82d5071ae893561a3f4af4b6#body_text
is schema:about of	named entity 'RNA' named entity 'ITS' named entity 'CARRIERS' named entity 'RAPID' named entity 'INTRINSIC' named entity 'COVERS' named entity 'RNA' named entity 'STRUCTURE' named entity 'APPROACHES' named entity 'SPECIFICITY' named entity 'NANOTECHNOLOGY' named entity 'SEQUENCE' named entity 'SPECIFIC' named entity 'CURRENT' named entity 'CONTROLLED' named entity 'POTENTIAL' named entity 'APPLICATIONS' named entity 'THESE' named entity 'FLEXIBILITY' named entity 'DEVELOPMENT' named entity 'intrinsically' named entity 'specificity' named entity 'nanotechnology' named entity 'silencing' named entity 'applications' named entity 'agents' named entity 'TARGETED' named entity 'NON-' named entity 'RIBOZYMES' named entity 'DUE TO' named entity 'RESEARCH' named entity 'CELLS' named entity 'ENGINEERING' named entity 'MEDICAL APPLICATION' named entity 'SIRNA DELIVERY' named entity 'PROBLEMS' named entity 'TARGET' named entity 'COMMUNITY' named entity 'USING' named entity 'TREATMENT' named entity 'DIFFERENT' named entity 'INTERESTING' named entity 'FOCUS' named entity 'LED' named entity 'FUNCTION' named entity 'SCALE' named entity 'LATEST' named entity 'VIRAL' named entity 'GENE EXPRESSION' named entity 'NUCLEIC ACIDS' named entity 'INVOLVED' named entity 'NANOMETRE' named entity 'THERAPEUTIC AGENTS' named entity 'FIELD' named entity 'MEDICAL' named entity 'VECTORS' named entity 'BASED' named entity 'METHODS' named entity 'CANDIDATE' named entity 'DEFINED' named entity 'CHALLENGES' named entity 'THERAPY' named entity 'VEHICLES' named entity 'IN VITRO' named entity 'MUCH' named entity 'THERAPEUTICS' named entity 'EFFICACY' named entity 'DISEASE' named entity 'SOLUTIONS' named entity 'IS A' named entity 'FASHION' named entity 'HUMAN DISEASE' named entity 'DELIVERY' named entity 'SCIENTIFIC' named entity 'SILENCE'

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