About: Ceramide in Stress Response

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Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Ceramide in Stress Response
Creator	Nikolova-Karakashian, Mariana Rozenova, Krassimira
Source	PMC
abstract	Evidence has consistently indicated that activation of sphingomyelinases and/or ceramide synthases and the resulting accumulation of ceramide mediate cellular responses to stressors such as lipopolysaccharide, interleukin 1ß, tumor necrosis factor a, serum deprivation, irradiation and various antitumor treatments. Recent studies had identified the genes encoding most of the enzymes responsible for the generation of ceramide and ongoing research is aimed at characterizing their individual functions in cellular response to stress. This chapter discusses the seminal and more recent discoveries in regards to the pathways responsible for the accumulation of ceramide during stress and the mechanisms by which ceramide affects cell functions. The former group includes the roles of neutral sphingomyelinase 2, serine palmitoyltransferase, ceramide synthases, as well as the secretory and endosomal/lysosomal forms of acid sphingomyelinase. The latter summarizes the mechanisms by which ceramide activate its direct targets, PKC?, PP2A and cathepsin D. The ability of ceramide to affect membrane organization is discussed in the light of its relevance to cell signaling. Emerging evidence to support the previously assumed notion that ceramide acts in a strictly structure-specific manner are also included. These findings are described in the context of several physiological and pathophysiological conditions, namely septic shock, obesity-induced insulin resistance, aging and apoptosis of tumor cells in response to radiation and chemotherapy.
has issue date	2010-12-24(xsd:dateTime)
bibo:doi	10.1007/978-1-4419-6741-1_6
bibo:pmid	20919648
has license	no-cc
sha1sum (hex)	11cbdd4c1c43fe5443920f7c35dc13496cff6bca
schema:url	https://doi.org/10.1007/978-1-4419-6741-1_6
resource representing a document's title	Ceramide in Stress Response
has PubMed Central identifier	PMC7122848
has PubMed identifier	20919648
schema:publication	Sphingolipids as Signaling and Regulatory Molecules
resource representing a document's body	covid:11cbdd4c1c43fe5443920f7c35dc13496cff6bca#body_text
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