About: Nasopharyngeal microbiota in infants and changes during viral upper respiratory tract infection and acute otitis media

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Nasopharyngeal microbiota in infants and changes during viral upper respiratory tract infection and acute otitis media Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Nasopharyngeal microbiota in infants and changes during viral upper respiratory tract infection and acute otitis media
Creator	Chonmaitree, Tasnee Fofanov, Yuriy Golovko, Georgiy Jennings, Kristofer Khanipov, Kamil Pimenova, Maria Loeffelholz, Michael Mccormick, David Patel, Janak
Source	Medline; PMC
abstract	BACKGROUND: Interferences between pathogenic bacteria and specific commensals are known. We determined the interactions between nasopharyngeal microbial pathogens and commensals during viral upper respiratory tract infection (URI) and acute otitis media (AOM) in infants. METHODS: We analyzed 971 specimens collected monthly and during URI and AOM episodes from 139 infants. The 16S rRNA V4 gene regions were sequenced on the Illumina MiSeq platform. RESULTS: Among the high abundant genus-level nasopharyngeal microbiota were Moraxella, Haemophilus, and Streptococcus (3 otopathogen genera), Corynebacterium, Dolosigranulum, Staphylococcus, Acinetobacter, Pseudomonas, and Bifidobacterium. Bacterial diversity was lower in culture-positive samples for Streptococcus pneumoniae, and Haemophilus influenzae, compared to cultured-negative samples. URI frequencies were positively associated with increasing trend in otopathogen colonization. AOM frequencies were associated with decreasing trend in Micrococcus colonization. During URI and AOM, there were increases in abundance of otopathogen genera and decreases in Pseudomonas, Myroides, Yersinia, and Sphingomonas. Otopathogen abundance was increased during symptomatic viral infection, but not during asymptomatic infection. The risk for AOM complicating URI was reduced by increased abundance of Staphylococcus and Sphingobium. CONCLUSION: Otopathogen genera played the key roles in URI and AOM occurrences. Staphylococcus counteracts otopathogens thus Staphylococcal colonization may be beneficial, rather than harmful. While Sphingobium may play a role in preventing AOM complicating URI, the commonly used probiotic Bifidobacterium did not play a significant role during URI or AOM. The role of less common commensals in counteracting the deleterious effects of otopathogens requires further studies.
has issue date	2017-07-14(xsd:dateTime)
bibo:doi	10.1371/journal.pone.0180630
bibo:pmid	28708872
has license	cc-by
sha1sum (hex)	11d016e4272c8a89fe7986afde61e6fb91908304
schema:url	https://doi.org/10.1371/journal.pone.0180630
resource representing a document's title	Nasopharyngeal microbiota in infants and changes during viral upper respiratory tract infection and acute otitis media
has PubMed Central identifier	PMC5510840
has PubMed identifier	28708872
schema:publication	PLoS One
resource representing a document's body	covid:11d016e4272c8a89fe7986afde61e6fb91908304#body_text
is schema:about of	named entity 'specific' named entity 'AOM' named entity 'URI' named entity 'INFANTS' covid:arg/11d016e4272c8a89fe7986afde61e6fb91908304 named entity 'DETERMINED' named entity 'MICROBIOTA' named entity 'INTERACTIONS' named entity 'NASOPHARYNGEAL' named entity 'CHANGES' named entity 'ACUTE OTITIS MEDIA' named entity 'VIRAL UPPER RESPIRATORY TRACT INFECTION' named entity 'MICROBIAL PATHOGENS' named entity 'BACTERIA ' named entity 'VIRAL UPPER RESPIRATORY TRACT INFECTION' named entity 'COMMENSALS' named entity 'ACUTE OTITIS MEDIA' named entity 'NASOPHARYNGEAL' named entity 'PATHOGENIC BACTERIA' named entity 'INFANTS' named entity 'SPECIFIC' named entity 'KNOWN' named entity 'Interferences' named entity 'determined' named entity 'infants' named entity 'commensals' named entity 'acute otitis media' named entity 'viral upper respiratory tract infection' named entity 'bacteria' named entity 'Haemophilus' named entity 'longitudinal studies' named entity 'Streptococcus pneumoniae' named entity 'AOM' named entity 'genus' named entity 'bacteriologic' named entity 'Pseudomonas' named entity 'URI' named entity 'false discovery rate' named entity 'Chimeras' named entity 'AOM' named entity 'URI' named entity 'nasopharyngeal' named entity 'commensals' named entity 'nasopharyngeal' named entity 'probiotics' named entity 'vaccines' named entity 'commensal' named entity 'AOM' named entity 'S. aureus' named entity 'Corynebacterium' named entity 'bacteria' named entity 'Illumina' named entity 'URI' named entity 'disease prevention' named entity 'Bifidobacterium' named entity 'Acinetobacter' named entity 'URIs' named entity 'antibiotics' named entity 'AOM' named entity 'archaea' named entity 'Enterobacter' named entity 'probiotic' named entity 'viral upper respiratory tract infection' named entity 'antibiotic' named entity 'Moraxella' named entity 'bacterial culture' named entity 'asymptomatic' named entity 'Staphylococcus' named entity 'nasopharyngeal' named entity 'Staphylococcus' named entity 'Staphylococcus' named entity 'commensals' named entity 'Dolosigranulum'

Faceted Search & Find service v1.13.91 as of Mar 24 2020

Alternative Linked Data Documents: Sponger | ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3229 as of Jul 10 2020, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (94 GB total memory)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software