About: Use of baculovirus expression system for generation of virus-like particles: Successes and challenges

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Use of baculovirus expression system for generation of virus-like particles: Successes and challenges
Creator	Li, Lin Wang, Zhiliang Wu, Xiaodong Liu, Fuxiao Liu, Zengshan
Source	Elsevier; Medline; PMC
abstract	Abstract The baculovirus expression system (BES) has been one of the versatile platforms for the production of recombinant proteins requiring multiple post-translational modifications, such as folding, oligomerization, phosphorylation, glycosylation, acylation, disulfide bond formation and proteolytic cleavage. Advances in recombinant DNA technology have facilitated application of the BES, and made it possible to express multiple proteins simultaneously in a single infection and to produce multimeric proteins sharing functional similarity with their natural analogs. Therefore, the BES has been used for the production of recombinant proteins and the construction of virus-like particles (VLPs), as well as for the development of subunit vaccines, including VLP-based vaccines. The VLP, which consists of one or more structural proteins but no viral genome, resembles the authentic virion but cannot replicate in cells. The high-quality recombinant protein expression and post-translational modifications obtained with the BES, along with its capacity to produce multiple proteins, imply that it is ideally suited to VLP production. In this article, we critically review the pros and cons of using the BES as a platform to produce both enveloped and non-enveloped VLPs.
has issue date	2013-08-31(xsd:dateTime)
bibo:doi	10.1016/j.pep.2013.05.009
bibo:pmid	23742819
has license	els-covid
sha1sum (hex)	121d9f9639fe01021279fbbe0980fe358e99d10b
schema:url	https://doi.org/10.1016/j.pep.2013.05.009
resource representing a document's title	Use of baculovirus expression system for generation of virus-like particles: Successes and challenges
has PubMed Central identifier	PMC7128112
has PubMed identifier	23742819
schema:publication	Protein Expression and Purification
resource representing a document's body	covid:121d9f9639fe01021279fbbe0980fe358e99d10b#body_text
is schema:about of	named entity 'SUCCESSES' named entity 'technology' named entity 'replicate' named entity 'consists' named entity 'SIMULTANEOUSLY' named entity 'VIRAL GENOME' named entity 'INCLUDING' named entity 'PHOSPHORYLATION' named entity 'VLP' named entity 'CLEAVAGE' named entity 'BASED' named entity 'PROTEOLYTIC' named entity 'POSSIBLE' named entity 'TO PRODUCE' named entity 'CONSTRUCTION' named entity 'USE OF' named entity 'SHARING' named entity 'USED' named entity 'BES' named entity 'BUT' named entity 'NATURAL' named entity 'CELLS' named entity 'DEVELOPMENT' named entity 'THEIR' named entity 'HAVE' named entity 'APPLICATION' named entity 'STRUCTURAL PROTEINS' named entity 'MULTIPLE' named entity 'PROTEINS' named entity 'FOLDING' named entity 'VIRION' named entity 'GLYCOSYLATION' named entity 'VIRUS-LIKE PARTICLES' named entity 'FORMATION' named entity 'SUBUNIT VACCINES' named entity 'TO EXPRESS' named entity 'RECOMBINANT DNA TECHNOLOGY' named entity 'DISULFIDE BOND' named entity 'ACYLATION' named entity 'ANALOGS' named entity 'POST-TRANSLATIONAL MODIFICATIONS' named entity 'CHALLENGES' named entity 'BACULOVIRUS EXPRESSION SYSTEM' named entity 'VIRUS-LIKE PARTICLES' named entity 'GENERATION' named entity 'SINGLE INFECTION' named entity 'FUNCTIONAL SIMILARITY' named entity 'RECOMBINANT PROTEINS' named entity 'VACCINES' named entity 'ONE OF' named entity 'PRODUCTION' named entity 'BACULOVIRUS EXPRESSION SYSTEM' named entity 'OLIGOMERIZATION' named entity 'REPLICATE' covid:arg/121d9f9639fe01021279fbbe0980fe358e99d10b named entity 'cells' named entity 'production' named entity 'similarity' named entity 'Advances' named entity 'baculoviruses' named entity 'homologous recombination' named entity 'human papillomavirus' named entity 'baculovirus' named entity 'chaperones' named entity 'VLPs' named entity 'insect cells' named entity 'kDa' named entity 'VLPs' named entity 'baculoviruses' named entity 'infection' named entity 'VLPs' named entity 'downstream processing' named entity 'baculovirus' named entity 'insect' named entity 'cell line' named entity 'protein' named entity 'RHDV'

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