About: Targeted tumour theranostics in mice via carbon quantum dots structurally mimicking large amino acids

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About: Targeted tumour theranostics in mice via carbon quantum dots structurally mimicking large amino acids Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Targeted tumour theranostics in mice via carbon quantum dots structurally mimicking large amino acids
Creator	Liu, Jun Wu, Hao Su, Wen Li, Miao Zhou, Yu Chen, Ann Zhou, Shixin Yuan, Ting Zhu, Jia Bao, Youmei Chen, Zeming Deng, Gang Fan, Louzhen Gao, Xingchun Li, Shuhua Li, Xiaohong Li, Yunchao Liu, Fuyao Tan, Hongwei Yuan, Chang Yuan, Fanglong Zhai, Xingchen Zhou, Jiangbing
Source	PMC
abstract	Strategies for selectively imaging and delivering drugs to tumours typically leverage differentially upregulated surface molecules on cancer cells. Here, we show that intravenously injected carbon quantum dots, functionalized with multiple paired α-carboxyl and amino groups that bind to the large neutral amino acid transporter 1 (which is expressed in most tumours), selectively accumulate in human tumour xenografts in mice and in an orthotopic mouse model of human glioma. The functionalized quantum dots, which structurally mimic large amino acids and can be loaded with aromatic drugs through π–π stacking interactions, enabled—in the absence of detectable toxicity—near-infrared fluorescence and photoacoustic imaging of the tumours and a reduction in tumour burden after the targeted delivery of chemotherapeutics to the tumours. The versatility of functionalization and high tumour selectivity of the quantum dots make them broadly suitable for tumour-specific imaging and drug delivery.
has issue date	2020-03-30(xsd:dateTime)
bibo:doi	10.1038/s41551-020-0540-y
bibo:pmid	32231314
has license	no-cc
sha1sum (hex)	122bda28e87f1106ffe022f942efb678bed2ea20
schema:url	https://doi.org/10.1038/s41551-020-0540-y
resource representing a document's title	Targeted tumour theranostics in mice via carbon quantum dots structurally mimicking large amino acids
has PubMed Central identifier	PMC7197249
has PubMed identifier	32231314
schema:publication	Nat Biomed Eng
resource representing a document's body	covid:122bda28e87f1106ffe022f942efb678bed2ea20#body_text
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