About: Synthesis, antitubercular and anticancer activity of new Baylis–Hillman adduct-derived N-cinnamyl-substituted isatin derivatives

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About: Synthesis, antitubercular and anticancer activity of new Baylis–Hillman adduct-derived N-cinnamyl-substituted isatin derivatives Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Synthesis, antitubercular and anticancer activity of new Baylis–Hillman adduct-derived N-cinnamyl-substituted isatin derivatives
Creator	Ravinder, Mettu Sriram, Darmarajan Yogeeswari, Perumal Bharath Kumar, Sriramoju Golla, • Rao, Jayathirtha Vaidya, Kishore
source	Medline; PMC
abstract	Baylis–Hillman adduct-derived N-cinnamyl-substituted isatin derivatives were synthesized and evaluated for their antitubercular activity on Mycobacterium tuberculosis H(37)Rv strain ATCC 27294 by agar dilution method. Anticancer activity for the same compounds was also screened on four different cell lines: Chinese hamster ovary (CHO cells), Colo 205 (human colon cancer), Sup-T1 (human lymphoma) and C6 glioma (rat glioma) by MTT assay method. The compounds (3j–l) have shown significant activity against Mycobacterium strain and the compound 3l has shown specific cytotoxic activity.
has issue date	2013-09-26(xsd:dateTime)
bibo:doi	10.1007/s00044-013-0787-x
bibo:pmid	32214765
has license	no-cc
sha1sum (hex)	123aeb506a00c84bc0ba38d819b62c3b027edc16
schema:url	https://doi.org/10.1007/s00044-013-0787-x
resource representing a document's title	Synthesis, antitubercular and anticancer activity of new Baylis–Hillman adduct-derived N-cinnamyl-substituted isatin derivatives
has PubMed Central identifier	PMC7080103
has PubMed identifier	32214765
schema:publication	Med Chem Res
resource representing a document's body	covid:123aeb506a00c84bc0ba38d819b62c3b027edc16#body_text
is schema:about of	named entity 'activity' named entity 'cancer' named entity 'Hillman' named entity 'NEW' named entity 'CYTOTOXIC' named entity 'HAVE' named entity 'COLON CANCER' named entity 'MTT ASSAY' named entity 'THEIR' named entity 'DIFFERENT' named entity 'EVALUATED' named entity 'AGAR DILUTION METHOD' named entity 'ASSAY METHOD' named entity 'ANTITUBERCULAR ACTIVITY' named entity 'C6 GLIOMA' named entity 'COMPOUND' named entity 'ISATIN DERIVATIVES' named entity 'MYCOBACTERIUM TUBERCULOSIS' named entity 'ANTITUBERCULAR' named entity 'ANTICANCER' covid:arg/123aeb506a00c84bc0ba38d819b62c3b027edc16 named entity 'OVARY' named entity 'CELL LINES' named entity 'ADDUCT' named entity 'ACTIVITY' named entity 'SYNTHESIS' named entity 'DERIVED' named entity 'ISATIN DERIVATIVES' named entity 'ANTICANCER' named entity 'SPECIFIC' named entity 'CELLS' named entity 'GLIOMA' named entity 'CHINESE HAMSTER' named entity 'SIGNIFICANT ACTIVITY' named entity 'BAYLIS-HILLMAN ADDUCT' named entity 'COLO 205' named entity 'MYCOBACTERIUM' named entity 'SYNTHESIZED' named entity 'ATCC' named entity 'ACTIVITY' named entity 'DERIVED' named entity 'SUP-T1' named entity 'LYMPHOMA' named entity 'STRAIN' named entity 'CHO cells' named entity 'dilution' named entity 'human' named entity 'screened' named entity 'Baylis-Hillman' named entity 'human colon cancer' named entity 'cell lines' named entity 'rat' named entity 'anticancer activity' named entity 'isatin' named entity 'biologically active' named entity 'biological properties' named entity 'adduct' named entity 'cell lines' named entity 'moiety' named entity 'steric' named entity 'Absorbance' named entity 'Ethambutol' named entity 'internal standard' named entity 'isatin' named entity '3:7' named entity 'Perkin-Elmer' named entity 'Bruker' named entity 'column chromatography' named entity 'MTT assay' named entity 'agar dilution' named entity 'cell lines' named entity 'Mycobacterium' named entity 'antitubercular' named entity 'pharmacologically' named entity 'cancer cells'

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