About: SARS-CoV-2 seroconversion in health care workers

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About: SARS-CoV-2 seroconversion in health care workers Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	SARS-CoV-2 seroconversion in health care workers
Creator	Bosworth, Andrew Crispin, Max Watanabe, Yasunori Allen, Joel Kidd, I Drayson, Mark Al-Taei, Saly Aldera, Erin Backhouse, Claire Beggs, Andrew Cunningham, Adam Dunbar, Lyndsey Ebanks, Daniel Emmanuel, Beena Faustini, Sian Grey, Joanne Jossi, Sian Mcginnell, Golaeh Mcloughlin, Dee Morley, Gabriella O'neill, Joanne Papakonstantinou, Danai Perez-Toledo, Marisol Pickles, Oliver Poxon, Charlotte Richter, Alex Richter, Megan Shields, Adrian Walker, Eloise Wanigasooriya, Kasun Whalley, Celina Wraith, David Zielinska, Agnieszka
topic	covid:12cbcc8e980bec6242df7df21cb271c8fa4fb0cb#this
Source	MedRxiv
abstract	Background The correlates of protection against SARS-CoV-2 and their longevity remain unclear. Studies in severely ill individuals have identified robust cellular and humoral immune responses against the virus. Asymptomatic infection with SARS-CoV-2 has also been described, but it is unknown whether this is sufficient to produce antibody responses. Methods We performed a cross-sectional study recruiting 554 health care workers from University Hospitals Birmingham NHS Foundation Trust who were at work and asymptomatic. Participants were tested for current infection with SARS-CoV-2 by nasopharyngeal swab for real-time polymerase chain reaction and for seroconversion by the measurement of anti-SARS-CoV-2 spike glycoprotein antibodies by enzyme linked immunosorbent assay. Results were interpreted in the context of previous, self-reported symptoms of illness consistent with COVID-19. Results The point prevalence of infection with SARS-CoV-2, determined by the detection of SARS-CoV-2 RNA on nasopharnygeal swab was 2.39% (n=13/544). Serum was available on 516 participants. The overall rate of seroconversion in the cohort was 24.4% (n=126/516). Individuals who had previously experienced a symptomatic illness consistent with COVID-19 had significantly greater seroconversion rates than those who had remained asymptomatic (37.5% vs 17.1%, {chi}2 =21.1034, p<0.0001). In the week preceding peak COVID-19-related mortality at UHBFT, seroconversion rates amongst those who were suffering from symptomatic illnesses peaked at 77.8%. Prior symptomatic illness generated quantitatively higher antibody responses than asymptomatic seroconversion. Seroconversion rates were highest amongst those working in housekeeping (34.5%), acute medicine (33.3%) and general internal medicine (30.3%) with lower rates observed in participants working in intensive care (14.8%) and emergency medicine (13.3%). Conclusions In a large cross-sectional seroprevalence study of health-care workers, we demonstrate that asymptomatic seroconversion occurs, however prior symptomatic illness is associated with quantitatively higher antibody responses. The identification that the potential for seroconversion in health-care workers can associate differentially with certain hospital departments may inform future infection control and occupational health practices.
has issue date	2020-05-19(xsd:dateTime)
bibo:doi	10.1101/2020.05.18.20105197
has license	medrxiv
sha1sum (hex)	12cbcc8e980bec6242df7df21cb271c8fa4fb0cb
schema:url	https://doi.org/10.1101/2020.05.18.20105197
resource representing a document's title	SARS-CoV-2 seroconversion in health care workers
resource representing a document's body	covid:12cbcc8e980bec6242df7df21cb271c8fa4fb0cb#body_text
is http://vocab.deri.ie/void#inDataset of	proxy:http/ns.inria.fr/covid19/12cbcc8e980bec6242df7df21cb271c8fa4fb0cb
is schema:about of	named entity 'The' named entity 'SEVERELY' named entity 'ROBUST' named entity 'UNCLEAR' named entity 'IMMUNE RESPONSES' named entity 'TO PRODUCE' named entity 'ILL' named entity 'ASYMPTOMATIC INFECTION' named entity 'SUFFICIENT' named entity 'peer review' named entity 'SARS' named entity 'Indices of deprivation' named entity 'PCR' named entity 'health-care' named entity 'antibodies' named entity 'high-risk' named entity 'seroconversion' named entity 'Serological' named entity 'health care workers' named entity 'medRxiv' named entity 'SARS-CoV-2' named entity 'COVID' named entity 'health-care' named entity 'SARS-CoV-2' named entity 'nasopharyngeal swabs' named entity 'COVID-19 pandemic' named entity 'SARS-CoV-2' named entity 'medRxiv' named entity 'general population' named entity 'seroprevalence' named entity 'nosocomial' named entity 'seroconversion' named entity 'real-time PCR' named entity 'exposure to the virus' named entity 'optical density' named entity 'Mann-Whitney U test' named entity 'health care workers' named entity 'risk of death' named entity 'University Hospitals Birmingham NHS Foundation Trust' named entity 'antibody response' named entity 'SARS-CoV-2' named entity 'intensive care' named entity 'point prevalence' named entity 'Serum' named entity 'antibody' named entity 'health care workers' named entity 'seroconversion' named entity 'RNA' named entity 'individuals' named entity 'virus' named entity 'Asymptomatic infection'

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