About: Infectious Complications during Tandem High-Dose Chemotherapy and Autologous Stem Cell Transplantation for Children with High-Risk or Recurrent Solid Tumors

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About: Infectious Complications during Tandem High-Dose Chemotherapy and Autologous Stem Cell Transplantation for Children with High-Risk or Recurrent Solid Tumors Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Infectious Complications during Tandem High-Dose Chemotherapy and Autologous Stem Cell Transplantation for Children with High-Risk or Recurrent Solid Tumors
Creator	Kim, Yae-Jean Kang, Ji-Man Lee, Ji Yoo, Keon Bae, Young Hoe, Hong Sang, Eun Woong Sung, Ki
source	Medline; PMC
abstract	We retrospectively analyzed infectious complications during tandem high-dose chemotherapy and autologous stem cell transplantation (HDCT/auto-SCT) in children and adolescents with high-risk or recurrent solid tumors. A total of 324 patients underwent their first HDCT/auto-SCT between October 2004 and September 2014, and 283 of them proceeded to their second HDCT/auto-SCT (a total of 607 HDCT/auto-SCTs). During the early transplant period of 607 HDCT/auto-SCTs (from the beginning of HDCT to day 30 post-transplant), bacteremia, urinary tract infection (UTI), respiratory virus infection, and varicella zoster virus (VZV) reactivation occurred in 7.1%, 2.3%, 13.0%, and 2.5% of HDCT/auto-SCTs, respectively. The early transplant period of the second HDCT/auto-SCT had infectious complications similar to the first HDCT/auto-SCT. During the late transplant period of HDCT/auto-SCT (from day 31 to 1 year post-transplant), bacteremia, UTI, and VZV reactivation occurred in 7.5%, 2.5%, and 3.9% of patients, respectively. Most infectious complications in the late transplant period occurred during the first 6 months post-transplant. There were no invasive fungal infections during the study period. Six patients died from infectious complications (4 from bacterial sepsis and 2 from respiratory virus infection). Our study suggests that infectious complications are similar following second and first HDCT/auto-SCT in children.
has issue date	2016-09-14(xsd:dateTime)
bibo:doi	10.1371/journal.pone.0162178
bibo:pmid	27627440
has license	cc-by
sha1sum (hex)	12d7a96036ca9e861d3636d55d3841452e455c73
schema:url	https://doi.org/10.1371/journal.pone.0162178
resource representing a document's title	Infectious Complications during Tandem High-Dose Chemotherapy and Autologous Stem Cell Transplantation for Children with High-Risk or Recurrent Solid Tumors
has PubMed Central identifier	PMC5023107
has PubMed identifier	27627440
schema:publication	PLoS One
resource representing a document's body	covid:12d7a96036ca9e861d3636d55d3841452e455c73#body_text
is schema:about of	named entity 'LATE' named entity 'AUTOLOGOUS STEM CELL TRANSPLANTATION' named entity 'SIMILAR' named entity 'INFECTIOUS COMPLICATIONS' named entity '283' named entity 'HIGH-DOSE CHEMOTHERAPY' named entity '3.9' named entity 'BACTERIAL SEPSIS' named entity 'OUR' named entity 'OCTOBER' named entity '607' named entity 'AUTO' named entity 'ANALYZED' named entity 'BEGINNING' named entity 'HIGH-RISK' named entity 'MONTHS' named entity 'TOTAL' named entity 'RESPIRATORY VIRUS INFECTION' named entity 'INFECTIOUS COMPLICATIONS' named entity 'BACTEREMIA' named entity 'ADOLESCENTS' named entity 'REACTIVATION' named entity 'POST-TRANSPLANT' named entity 'SCTS' named entity 'CHILDREN' named entity 'HDCT' named entity 'SECOND' named entity 'INVASIVE FUNGAL INFECTIONS' named entity 'TANDEM' named entity 'PATIENTS' named entity 'YEAR' named entity 'SOLID TUMORS' named entity '7.5' covid:arg/12d7a96036ca9e861d3636d55d3841452e455c73 named entity 'RECURRENT' named entity 'TANDEM' named entity 'AUTOLOGOUS STEM CELL TRANSPLANTATION' named entity 'SOLID TUMORS' named entity 'HIGH-DOSE CHEMOTHERAPY' named entity 'HIGH-RISK' named entity 'PERIOD' named entity 'THEIR' named entity 'DIED' named entity '324' named entity 'VARICELLA ZOSTER VIRUS' named entity 'STUDY' named entity 'TRANSPLANT' named entity 'OCCURRED' named entity 'FOLLOWING' named entity 'VZV' named entity 'FOR CHILDREN' named entity 'RECURRENT' named entity 'EARLY' named entity 'DAY' named entity '2.5' named entity 'URINARY TRACT INFECTION' named entity '28A' named entity 'SEPTEMBER' named entity 'SCT' named entity 'UTI' named entity 'complications' named entity 'patients' named entity 'complications' named entity 'Six' named entity 'September' named entity 'transplant' named entity 'During' named entity 'late' named entity 'study' named entity 'sepsis' named entity 'late' named entity 'VZV' named entity 'autologous stem cell transplantation' named entity 'bacteremia'

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