About: Immunoglobulin heavy chain diversity in Pteropid bats: evidence for a diverse and highly specific antigen binding repertoire

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About: Immunoglobulin heavy chain diversity in Pteropid bats: evidence for a diverse and highly specific antigen binding repertoire Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Immunoglobulin heavy chain diversity in Pteropid bats: evidence for a diverse and highly specific antigen binding repertoire
Creator	Wang, Lin-Fa Tachedjian, Mary Baker, Michelle
Source	Medline; PMC
abstract	Bats are the natural host reservoir for range of emerging and re-emerging viruses, many of which cause significant morbidity and mortality in other mammals, yet appear to result in no clinical consequences for bats. The ability of bats to coexist with a variety of viruses presents an interesting immunological problem that has not been examined in any detail but which could provide significant insights into the evolution of antiviral mechanisms in mammals. Towards a better understanding of the bat immune system, we analysed the expressed heavy chain variable (VH) regions of antibodies from the black flying fox, Pteropus alecto. The germline repertoire of the closely related Pteropid bat, Pteropus vampyrus, whose genome has been sequenced was also examined for comparative purposes. Representative VH genes were found in all three mammalian VH clans (I, II and III) in both the expressed P. alecto VH repertoire and the germline P. vampyrus VH repertoire. Evidence for the use of multiple heavy chain diversity (DH) and joining (JH) segments for the generation of diverse VDJ rearrangements was also present in the expressed antibody repertoire of P. alecto. The long period of co-evolutionary history of bats with viruses may have resulted in a variety of highly specific VH segments being hardwired into the genomes of bats and may have implications for their ability to successfully cope with a diversity of viral antigens.
has issue date	2010-02-17(xsd:dateTime)
bibo:doi	10.1007/s00251-010-0425-4
bibo:pmid	20162414
has license	no-cc
sha1sum (hex)	12d9952ba3cf8410eff072c9ec3b62447457122d
schema:url	https://doi.org/10.1007/s00251-010-0425-4
resource representing a document's title	Immunoglobulin heavy chain diversity in Pteropid bats: evidence for a diverse and highly specific antigen binding repertoire
has PubMed Central identifier	PMC2887692
has PubMed identifier	20162414
schema:publication	Immunogenetics
resource representing a document's body	covid:12d9952ba3cf8410eff072c9ec3b62447457122d#body_text
is schema:about of	named entity 'DIVERSITY' named entity 'clans' named entity 'genome' named entity 'regions' named entity 'bats' named entity 'immunological' named entity 'bats' named entity 'MAMMALS' named entity 'ANTIBODY REPERTOIRE' named entity 'REGIONS' named entity 'APPEAR' named entity 'ANTIVIRAL' named entity 'BEING' named entity 'MECHANISMS' named entity 'UNDERSTANDING' named entity 'BLACK FLYING FOX' named entity 'III' named entity 'SPECIFIC' named entity 'EVOLUTION' named entity 'PURPOSES' named entity 'USE OF' named entity 'ANTIBODIES' named entity 'MULTIPLE' named entity 'GERMLINE' named entity 'MAY HAVE' named entity 'INSIGHTS' named entity 'SEGMENTS' named entity 'VAMPYRUS' named entity 'PTEROPUS VAMPYRUS' named entity 'LONG' named entity 'HIGHLY' named entity 'GENOME' named entity 'FOUND' named entity 'PROVIDE' named entity 'PRESENT' named entity 'BETTER' named entity 'EVOLUTIONARY HISTORY' named entity 'VARIETY' named entity 'MAMMALIAN' named entity 'DIVERSITY' named entity 'VARIABLE' named entity 'CLINICAL' named entity 'BATS' named entity 'BUT' named entity 'HEAVY CHAIN' named entity 'HOST' named entity 'PERIOD' named entity 'REPRESENTATIVE' named entity 'ABILITY' named entity '28I' named entity 'RELATED' named entity 'JOINING' named entity 'REARRANGEMENTS' named entity 'GENOMES' named entity 'CONSEQUENCES' named entity 'SIGNIFICANT' named entity 'EXAMINED FOR' named entity 'VIRAL ANTIGENS' named entity 'CAUSE' named entity 'GENES' named entity 'PROBLEM' named entity 'PRESENTS' named entity 'EVIDENCE FOR' named entity 'HIGHLY' named entity 'ANTIGEN BINDING' named entity 'BATS' named entity 'REPERTOIRE' named entity 'SPECIFIC ANTIGEN' named entity 'IMMUNOGLOBULIN HEAVY CHAIN' named entity 'EVIDENCE FOR' named entity 'BAT' named entity 'RANGE' named entity 'HISTORY OF' named entity 'EXAMINED' named entity 'IMMUNE SYSTEM' named entity 'RESERVOIR' named entity 'COPE' named entity 'GENERATION' named entity 'INTERESTING'

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