About: LncRNAs and immunity: watchdogs for host pathogen interactions

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	LncRNAs and immunity: watchdogs for host pathogen interactions
Creator	Dar, Ahmad Ahmed, Raashid Ayaz, Aadil Bhat, Shakil Ganai, Nazir Shah, Riaz Shrivastava, Divya Urwat, Uneeb Mudasir Ahmad, Syed Tajamul Mumtaz, Peerzada
Source	PMC
abstract	Immune responses combat various infectious agents by inducing inflammatory responses, antimicrobial pathways and adaptive immunity. The polygenic responses to these external stimuli are temporally and coordinately regulated. Specific lncRNAs are induced to modulate innate and adaptive immune responses which can function through various target interactions like RNA-DNA, RNA-RNA, and RNA-protein interaction and hence affect the immunogenic regulation at various stages of gene expression. LncRNA are found to be present in various immune cells like monocytes, macrophages, dendritic cells, neutrophils, T cells and B cells. They have been shown to be involved in many biological processes, including the regulation of the expression of genes, the dosage compensation and genomics imprinting, but the knowledge how lncRNAs are regulated and how they alter cell differentiation/function is still obscure. Further dysregulation of lncRNA has been seen in many diseases, but as yet very less research has been carried out to understand the role of lncRNAs in regulation during host-pathogens interactions. In this review, we summarize the functional developments and mechanism of action of lncRNAs, in immunity and defense of host against pathogens.
has issue date	2017-04-27(xsd:dateTime)
bibo:doi	10.1186/s12575-017-0052-7
bibo:pmid	28465674
has license	cc-by
sha1sum (hex)	12de52d9061626d8f163666f7da428b9cb7c94c2
schema:url	https://doi.org/10.1186/s12575-017-0052-7
resource representing a document's title	LncRNAs and immunity: watchdogs for host pathogen interactions
has PubMed Central identifier	PMC5406993
has PubMed identifier	28465674
schema:publication	Biol Proced Online
resource representing a document's body	covid:12de52d9061626d8f163666f7da428b9cb7c94c2#body_text
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