About: Improvement of the C-glycosylation Step for the Synthesis of Remdesivir

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About: Improvement of the C-glycosylation Step for the Synthesis of Remdesivir Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Improvement of the C-glycosylation Step for the Synthesis of Remdesivir
Creator	Wang, Ke Zhong, Wu Xue, Fei Qin, Yong Xiang, Ji Xiao, Dian Zhou, Xinbo Gu, Eric Guo, Xiaowen Yang, Likai Zhou, Ruijie Zhou, Xiaohan
Source	PMC
abstract	[Image: see text] The bulk supply of the antiviral C-nucleoside analogue remdesivir is largely hampered by a low-yielding C-glycosylation step in which the base is coupled to the pentose unit. Here, we disclose a significantly improved methodology for this critical transformation. By utilizing diisopropylamine as a cost-effective additive, the addition reaction furnishes an optimal yield of 75% of the desired ribofuranoside adduct, representing the highest yield obtained thus far for this key step. The method proved suitable for hectogram scale synthesis without column chromatographic operations.
has issue date	2020-08-05(xsd:dateTime)
bibo:doi	10.1021/acs.oprd.0c00310
has license	no-cc
sha1sum (hex)	12f5d1ea103b1a5f1b864eb28e430b1369960001
schema:url	https://doi.org/10.1021/acs.oprd.0c00310
resource representing a document's title	Improvement of the C-glycosylation Step for the Synthesis of Remdesivir
has PubMed Central identifier	PMC7433339
schema:publication	Org Process Res Dev
resource representing a document's body	covid:12f5d1ea103b1a5f1b864eb28e430b1369960001#body_text
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