About: Multicenter Evaluation of the ePlex Respiratory Pathogen Panel for the Detection of Viral and Bacterial Respiratory Tract Pathogens in Nasopharyngeal Swabs

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About: Multicenter Evaluation of the ePlex Respiratory Pathogen Panel for the Detection of Viral and Bacterial Respiratory Tract Pathogens in Nasopharyngeal Swabs Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Multicenter Evaluation of the ePlex Respiratory Pathogen Panel for the Detection of Viral and Bacterial Respiratory Tract Pathogens in Nasopharyngeal Swabs
Creator	Tang, Yi-Wei Greene, Wallace He, Taojun Menegus, Marilyn Babady, N Chamberland, Robin England, Matthew Jerris, Robert Swierkosz, Ella Wijetunge, Dona Smith, Kristen
topic	covid:137c77a97b865b5d85e90b50782a1bdf78539ec4#this
Source	Medline; PMC
abstract	The performance of the new ePlex Respiratory Pathogen (RP) panel (GenMark Diagnostics) for the simultaneous detection of 19 viruses (influenza A virus; influenza A H1 virus; influenza A 2009 H1 virus; influenza A H3 virus; influenza B virus; adenovirus; coronaviruses [HKU1, OC43, NL63, and 229E]; human rhinovirus/enterovirus; human metapneumovirus; parainfluenza viruses 1, 2, 3, and 4; and respiratory syncytial virus [RSV] [RSV subtype A and RSV subtype B]) and 2 bacteria (Mycoplasma pneumoniae and Chlamydia pneumoniae) was evaluated. Prospectively and retrospectively collected nasopharyngeal swab (NPS) specimens (n = 2,908) were evaluated by using the ePlex RP panel, with the bioMérieux/BioFire FilmArray Respiratory Panel (BioFire RP) as the comparator method. Discordance analysis was performed by using target-specific PCRs and bidirectional sequencing. The reproducibility of the assay was evaluated by using reproducibility panels comprised of 6 pathogens. The overall agreement between the ePlex RP and BioFire RP results was >95% for all targets. Positive percent agreement with the BioFire RP result for viruses ranged from 85.1% (95% confidence interval [CI], 80.2% to 88.9%) to 95.1% (95% CI, 89.0% to 97.9%), while negative percent agreement values ranged from 99.5% (95% CI, 99.1% to 99.7%) to 99.8% (95% CI, 99.5% to 99.9%). Additional testing of discordant targets (12%; 349/2,908) confirmed the results of ePlex RP for 38% (131/349) of samples tested. Reproducibility was 100% for all targets tested, with the exception of adenovirus, for which reproducibilities were 91.6% at low virus concentrations and 100% at moderate virus concentrations. The ePlex RP panel offers a new, rapid, and sensitive “sample-to-answer” multiplex panel for the detection of the most common viral and bacterial respiratory pathogens.
has issue date	2018-01-24(xsd:dateTime)
bibo:doi	10.1128/jcm.01658-17
bibo:pmid	29212701
has license	cc-by
sha1sum (hex)	137c77a97b865b5d85e90b50782a1bdf78539ec4
schema:url	https://doi.org/10.1128/jcm.01658-17
resource representing a document's title	Multicenter Evaluation of the ePlex Respiratory Pathogen Panel for the Detection of Viral and Bacterial Respiratory Tract Pathogens in Nasopharyngeal Swabs
has PubMed Central identifier	PMC5786739
has PubMed identifier	29212701
schema:publication	J Clin Microbiol
resource representing a document's body	covid:137c77a97b865b5d85e90b50782a1bdf78539ec4#body_text
is http://vocab.deri.ie/void#inDataset of	https://covidontheweb.inria.fr:4443/about/id/http/ns.inria.fr/covid19/137c77a97b865b5d85e90b50782a1bdf78539ec4
is schema:about of	named entity 'HUMAN RHINOVIRUS' named entity 'NEW' named entity 'INFLUENZA A' named entity 'CORONAVIRUSES' named entity 'VIRUS' named entity 'OC43' named entity 'HUMAN METAPNEUMOVIRUS' named entity 'SIMULTANEOUS' named entity 'PERFORMANCE' named entity 'PATHOGEN' named entity 'RSV' covid:arg/137c77a97b865b5d85e90b50782a1bdf78539ec4 named entity 'RESPIRATORY TRACT' named entity '229E' named entity 'DIAGNOSTICS' named entity 'PANEL' named entity 'DETECTION' named entity 'RESPIRATORY' named entity 'BACTERIAL' named entity 'EVALUATION' named entity 'NASOPHARYNGEAL' named entity 'VIRAL AND' named entity 'SWABS' named entity 'RESPIRATORY PATHOGEN PANEL' named entity 'RESPIRATORY SYNCYTIAL VIRUS' named entity 'SUBTYPE' named entity 'NL63' named entity 'PATHOGENS' named entity 'DETECTION' named entity 'INFLUENZA B VIRUS' named entity 'RSV' named entity 'VIRUSES' named entity 'ADENOVIRUS' named entity 'PARAINFLUENZA' named entity 'influenza B virus' named entity 'influenza A' named entity 'virus' named entity 'influenza A virus' named entity 'RSV' named entity 'influenza A virus' named entity 'human metapneumovirus' named entity 'RSV' named entity 'enterovirus' named entity 'Pathogen' named entity 'adenovirus' named entity 'coronavirus' named entity 'false negative' named entity 'PCR' named entity 'adenovirus' named entity 'immunocompromised' named entity 'touch screen' named entity 'respiratory tract infections' named entity 'Bordetella pertussis' named entity 'OC43' named entity 'multiplexed' named entity 'self-limited' named entity 'coinfected' named entity 'pathogens' named entity 'pathogen' named entity 'C. pneumoniae' named entity 'hematopoietic stem cell transplant' named entity 'Chlamydia pneumoniae' named entity 'OC43' named entity 'Study population' named entity 'Morrisville, NC' named entity 'NL63' named entity 'adenovirus' named entity 'pathogens' named entity 'pathogens'

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