About: Mouse LSECtin as a model for a human Ebola virus receptor

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About: Mouse LSECtin as a model for a human Ebola virus receptor Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Mouse LSECtin as a model for a human Ebola virus receptor
Creator	Pöhlmann, Stefan Steffen, Imke Drickamer, Kurt Pipirou, Zoi Taylor, Maureen Powlesland, Alex
topic	covid:13f055e666f5a05c1f18856409f9b8f4ac4ae4ce#this
Source	Medline; PMC
abstract	The biochemical properties of mouse LSECtin, a glycan-binding receptor that is a member of the C-type lectin family found on sinusoidal endothelial cells, have been investigated. The C-type carbohydrate-recognition domain of mouse LSECtin, expressed in bacteria, has been used in solid-phase binding assays, and a tetramerized form has been used to probe a glycan array. In spite of sequence differences near the glycan-binding sites, the mouse receptor closely mimics the properties of the human receptor, showing high affinity binding to glycans bearing terminal GlcNAcβ1-2Man motifs. Site-directed mutagenesis has been used to confirm that residues near the binding site that differ between the human and the mouse proteins do not affect this binding specificity. Mouse and human LSECtin have been shown to bind Ebola virus glycoprotein with equivalent affinities, and the GlcNAcβ1-2Man disaccharide has been demonstrated to be an effective inhibitor of this interaction. These studies provide a basis for using mouse LSECtin, and knockout mice lacking this receptor, to model the biological properties of the human receptor.
has issue date	2011-01-21(xsd:dateTime)
bibo:doi	10.1093/glycob/cwr008
bibo:pmid	21257728
has license	cc-by-nc
sha1sum (hex)	13f055e666f5a05c1f18856409f9b8f4ac4ae4ce
schema:url	https://doi.org/10.1093/glycob/cwr008
resource representing a document's title	Mouse LSECtin as a model for a human Ebola virus receptor
has PubMed Central identifier	PMC3091528
has PubMed identifier	21257728
schema:publication	Glycobiology
resource representing a document's body	covid:13f055e666f5a05c1f18856409f9b8f4ac4ae4ce#body_text
is http://vocab.deri.ie/void#inDataset of	proxy:http/ns.inria.fr/covid19/13f055e666f5a05c1f18856409f9b8f4ac4ae4ce
is schema:about of	named entity 'FAMILY' named entity 'DEMONSTRATED' named entity 'TERMINAL' named entity 'IS A' named entity 'BINDING ASSAYS' named entity 'RECEPTOR' named entity 'PROPERTIES' named entity 'GLYCANS' named entity 'DISACCHARIDE' named entity 'MOTIFS' named entity 'BIOLOGICAL PROPERTIES' named entity 'MEMBER OF' named entity 'BINDING SPECIFICITY' named entity 'B21' named entity 'LACKING' named entity 'DO NOT' named entity 'HIGH' named entity 'PROBE' named entity 'GLYCAN ARRAY' named entity 'MODEL' named entity 'AFFECT' named entity 'EQUIVALENT' named entity 'USING' named entity 'SINUSOIDAL' named entity 'binding' named entity 'biological' named entity 'investigated' named entity 'Mouse' named entity 'PROVIDE' named entity 'CONFIRM' named entity 'SEQUENCE' named entity 'ENDOTHELIAL CELLS' named entity 'BIND' named entity 'INVESTIGATED' named entity 'EBOLA VIRUS' named entity 'FOUND' named entity 'RECOGNITION' named entity 'TYPE' named entity 'GLCNAC' named entity 'SITE-DIRECTED MUTAGENESIS' named entity 'EXPRESSED' named entity 'BINDING SITES' named entity 'BASIS' named entity 'LSECTIN' named entity 'MOUSE' named entity 'HUMAN' named entity 'MOUSE' named entity 'MIMICS' named entity 'CARBOHYDRATE' named entity 'BIOCHEMICAL' named entity 'HAVE' named entity 'FORM' named entity 'AFFINITY' named entity 'USED' named entity 'BINDING SITE' named entity 'BACTERIA' named entity 'GLYCOPROTEIN' named entity 'INHIBITOR' named entity 'HUMAN' named entity 'MODEL' named entity 'THESE' named entity 'STUDIES' named entity 'EBOLA VIRUS' named entity 'LECTIN' named entity 'NEAR' named entity 'VIRUS RECEPTOR' named entity 'SOLID' named entity 'EFFECTIVE' named entity 'KNOCKOUT MICE' named entity 'INTERACTION' named entity 'GLYCAN' named entity 'BINDING' named entity 'LSECTIN' named entity 'PHASE'

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