About: Natural history and epidemiology of respiratory syncytial virus infection in the Middle East: Hospital surveillance for children under age two in Jordan

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About: Natural history and epidemiology of respiratory syncytial virus infection in the Middle East: Hospital surveillance for children under age two in Jordan Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Natural history and epidemiology of respiratory syncytial virus infection in the Middle East: Hospital surveillance for children under age two in Jordan
Creator	Wang, Li Faouri, Samir Fonnesbeck, Christopher Halasa, Natasha Khuri-Bulos, Najwa Shehabi, Asem Williams, John Vermund, Sten
Source	Elsevier; Medline; PMC
abstract	Abstract Respiratory syncytial virus (RSV) is the leading cause of bronchiolitis and viral pneumonia in infants and young children worldwide. In the Middle East and Arab countries, the burden of RSV-associated hospitalizations is not well characterized. We sought to determine the burden and clinical/epidemiological characteristics of RSV hospitalization in young children in Amman, Jordan. We investigated risk factors for severity including vitamin D levels. Methods We conducted viral surveillance with clinical and demographic data in children <2 years admitted with respiratory symptoms and/or fever at the Al-Bashir Government Hospital from March16, 2010 to March 31, 2013. Nasal/throat swabs were obtained and placed into lysis buffer, and frozen at −80°C until testing by real-time RT-PCR for 11 respiratory viruses. Heel stick blood or sera samples for 25-hydroxyvitamin D [25(OH)D] levels were obtained and sent to a central laboratory for mass spectrometry. Results Of the 3168 children, >80% testing positive for one virus, with RSV the most common virus detected (44%). The RSV-associated hospitalization rate was highest in children <6 months with an annual range of 21.1–25.9 per 1000, compared to 6.0–8.0 in 6–11-month-olds and 1.6–2.5 in 12–23-month-olds. RSV-positive children compared with RSV-negative were more likely to be previously healthy without underlying medical conditions, less likely to be born prematurely, had a higher frequency of supplemental oxygen use, and had lower median vitamin D levels. Risk factors for oxygen use in RSV-positive children included underlying medical conditions, lack of breastfeeding, younger age, and higher viral load. Conclusion RSV is a major cause of illness in hospitalized Jordanian children and is associated with increased severity compared to other respiratory viruses. Children with RSV in the Middle East would benefit from future RSV vaccines and antiviral therapy.
has issue date	2015-11-25(xsd:dateTime)
bibo:doi	10.1016/j.vaccine.2015.08.048
bibo:pmid	26314623
has license	els-covid
sha1sum (hex)	140c32554663e4033d23a392bd287b0239bfe1d1
schema:url	https://doi.org/10.1016/j.vaccine.2015.08.048
resource representing a document's title	Natural history and epidemiology of respiratory syncytial virus infection in the Middle East: Hospital surveillance for children under age two in Jordan
has PubMed Central identifier	PMC7115487
has PubMed identifier	26314623
schema:publication	Vaccine
resource representing a document's body	covid:140c32554663e4033d23a392bd287b0239bfe1d1#body_text
is schema:about of	named entity 'SURVEILLANCE' named entity 'FOR CHILDREN' named entity 'JORDAN' named entity 'hospitalizations' named entity 'RSV' named entity 'testing' named entity 'laboratory' named entity 'hospitalized' named entity 'blood' named entity 'epidemiological' named entity 'Arab countries' named entity 'March' named entity 'infection' named entity 'WORLDWIDE' named entity 'DETECTED' named entity 'FUTURE' named entity 'HEEL STICK' named entity 'MEDICAL' named entity 'PREVIOUSLY' named entity 'BREASTFEEDING' named entity 'BORN' named entity 'CHARACTERIZED' named entity 'CONDITIONS' named entity 'RESPIRATORY VIRUSES' named entity 'FREQUENCY' named entity 'HIGHEST' named entity 'RISK FACTORS' named entity 'MASS SPECTROMETRY' named entity 'POSITIVE' named entity 'MARCH' named entity 'COMMON' named entity 'SAMPLES' named entity 'YOUNG CHILDREN' named entity 'JORDAN' named entity 'YOUNGER AGE' named entity 'OLDS' named entity 'ILLNESS' named entity 'SWABS' named entity 'HEALTHY' named entity 'CHILDREN' named entity 'YEARS' named entity 'VITAMIN D' named entity 'ANTIVIRAL THERAPY' named entity 'ASSOCIATED' named entity 'TESTING' named entity 'SURVEILLANCE' named entity 'SUPPLEMENTAL OXYGEN' named entity 'ASSOCIATED WITH' named entity 'AMMAN' named entity 'NEGATIVE' named entity 'NOT WELL' named entity 'ARAB COUNTRIES' named entity '1.6' named entity 'JORDANIAN' named entity 'SEVERITY' named entity 'LYSIS BUFFER' named entity '2.5' named entity 'EPIDEMIOLOGY' named entity 'USE' named entity 'RESPIRATORY SYNCYTIAL VIRUS' named entity 'DETERMINE' named entity 'FEVER' named entity 'LEVELS' named entity 'ADMITTED' named entity 'INCREASED' named entity 'CAUSE' named entity 'IS A' named entity 'A MAJOR' named entity 'LOWER' named entity 'MONTH' named entity 'INVESTIGATED' named entity 'CLINICAL' named entity 'MIDDLE EAST' named entity 'HOSPITALIZED'

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