About: Detection of rhinovirus in induced sputum at exacerbation of chronic obstructive pulmonary disease

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About: Detection of rhinovirus in induced sputum at exacerbation of chronic obstructive pulmonary disease Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Detection of rhinovirus in induced sputum at exacerbation of chronic obstructive pulmonary disease
Creator	Seemungal, T Wedzicha, J Jeffries, D Bhowmik, A Bhowmik, D Harper-Owen, A Harper-Owen, R Jeffries, J Seemungal, R
Source	Medline; PMC
abstract	Common colds are associated with exacerbations of chronic obstructive pulmonary disease (COPD). However, the role of the common cold virus (human rhinovirus) in the production of symptoms and lower airway inflammation at COPD exacerbation is unknown. Thirty three patients with moderate‐to‐severe COPD were seen at baseline, when the number of chest infections in the previous year was noted, and acutely at COPD exacerbation. Within 48 h after the onset of the exacerbation and at baseline, nasal aspirates and induced sputum were taken for rhinovirus reverse transcriptase polymerase chain reaction (RT‐PCR) analysis and determination of cytokine levels. Symptoms, recorded on diary cards, were noted and forced expiratory volume in one second (FEV1) and forced vital capacity (FVC) measured. At exacerbation, mean FEV1 and FVC fell significantly from baseline (p<0.001). Ten of 43 exacerbations were associated with rhinovirus infection, detected in induced sputum. In four of these, nasophageal samples contained no detectable rhinovirus. All baseline samples were negative for rhinovirus. The simultaneous presence of increased nasal discharge/nasal congestion (in 26 of the 43 exacerbations) and increased sputum (29 exacerbations) was strongly associated with the presence of rhinovirus (odds ratio 6.15; p=0.036). Total symptom scores were greater for rhinovirus as compared to nonrhinovirus exacerbations (p=0.039). Median baseline sputum interleukin‐6 levels rose from 90.2 to 140.3 pg·mL(‐1) at exacerbation (p=0.005); the change was greater in the presence of rhinovirus infection (p=0.008). Rhinovirus infection can be detected at chronic obstructive pulmonary disease exacerbation. This is associated with elevation of lower airway interleukin‐6 levels, which may mediate lower airway symptom expression during chronic obstructive pulmonary disease exacerbations.
has issue date	2001-12-25(xsd:dateTime)
bibo:doi	10.1034/j.1399-3003.2000.16d19.x
bibo:pmid	11106212
has license	no-cc
sha1sum (hex)	14a74c819bafd59b3d6c41c5cc31e5f921d94cc7
schema:url	https://doi.org/10.1034/j.1399-3003.2000.16d19.x
resource representing a document's title	Detection of rhinovirus in induced sputum at exacerbation of chronic obstructive pulmonary disease
has PubMed Central identifier	PMC7163563
has PubMed identifier	11106212
schema:publication	Eur Respir J
resource representing a document's body	covid:14a74c819bafd59b3d6c41c5cc31e5f921d94cc7#body_text
is schema:about of	named entity 'However' named entity 'chronic obstructive pulmonary disease' named entity 'SYMPTOMS' named entity 'UNKNOWN' named entity 'COMMON COLDS' named entity 'PRODUCTION' covid:arg/14a74c819bafd59b3d6c41c5cc31e5f921d94cc7 named entity 'rhinovirus' named entity 'sputum' named entity 'chronic obstructive pulmonary disease' named entity 'common cold virus' named entity 'human rhinovirus' named entity 'rhinovirus' named entity 'chronic obstructive pulmonary disease' named entity 'rhinovirus' named entity 'supernatant' named entity 'lower airway' named entity 'molecular biology' named entity 'IL-8' named entity 'primer' named entity 'rhinovirus' named entity 'Paisley' named entity 'Polymerase chain reaction' named entity 'primers' named entity 'infection' named entity 'COPD exacerbation' named entity 'cytokine' named entity 'upper respiratory tract infections' named entity 'sputum' named entity 'virally induced' named entity 'mucus' named entity 'infection' named entity 'lower airway' named entity 'nuclear factor' named entity 'upper airway' named entity 'agonist' named entity 'rhinovirus' named entity 'supernatant' named entity 'Warrington' named entity 'molecular biology' named entity 'lower airway' named entity 'rhinovirus' named entity 'interleukin-6' named entity 'rhinovirus' named entity 'gel electrophoresis' named entity 'IL-6' named entity 'COPD exacerbations' named entity 'sputum' named entity 'Biotechnologies' named entity 'catheter' named entity 'infection' named entity 'supernatant' named entity 'lower airway' named entity 'salbutamol' named entity 'Deoxyribonucleic acid' named entity 'sputum' named entity 'symptom' named entity 'rhinovirus' named entity 'anterior nares' named entity 'rhinovirus' named entity 'rhinovirus' named entity 'lower airway' named entity 'nasopharyngeal' named entity 'symptom' named entity 'bronchitis' named entity 'Abingdon' named entity 'Yorba Linda' named entity 'sputum' named entity 'rhinovirus' named entity 'purulence' named entity 'rhinovirus' named entity 'COPD' named entity 'COPD exacerbations'

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