About: C-type lectin LSECtin interacts with DC-SIGNR and is involved in hepatitis C virus binding

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About: C-type lectin LSECtin interacts with DC-SIGNR and is involved in hepatitis C virus binding Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	C-type lectin LSECtin interacts with DC-SIGNR and is involved in hepatitis C virus binding
Creator	Li, Yi Tang, Li Yang, Juntao Ae, Chen Ae, Hao Ae, Xing Ae, Zhang Bingtao, A Guichun, A Jie, A Kuai, Xuezhang Lingqiang, A
Source	Medline; PMC
abstract	Hepatitis C virus (HCV) is a major cause of liver disease. However, the detailed mechanism underlying hepatocyte infection with HCV is not yet completely understood. We previously identified a novel C-type lectin—LSECtin predominantly expressed on liver sinusoidal endothelial cells. Here we demonstrate that LSECtin can interact with two HCV receptors, DC-SIGNR and CD81, through its central ectodomain. Furthermore, cells expressing LSECtin specifically can be attached by the naturally occurring HCV in the sera of infected individuals. This binding was found to be mediated by the HCV E2 glycoprotein and could be efficiently inhibited by EGTA but not by mannan treatment. The present study suggests that LSECtin interaction with DC-SIGNR might contribute to HCV binding to liver sinusoidal endothelial cells. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s11010-009-0056-y) contains supplementary material, which is available to authorized users.
has issue date	2009-02-21(xsd:dateTime)
bibo:doi	10.1007/s11010-009-0056-y
bibo:pmid	19234677
has license	no-cc
sha1sum (hex)	14aae1385e314505aefe392e22d78bcf4f75f532
schema:url	https://doi.org/10.1007/s11010-009-0056-y
resource representing a document's title	C-type lectin LSECtin interacts with DC-SIGNR and is involved in hepatitis C virus binding
has PubMed Central identifier	PMC7088854
has PubMed identifier	19234677
schema:publication	Mol Cell Biochem
resource representing a document's body	covid:14aae1385e314505aefe392e22d78bcf4f75f532#body_text
is schema:about of	named entity 'HCV' named entity 'cells' named entity 'HCV' named entity 'hepatitis C virus' named entity 'HCV' named entity 'INTERACTION' named entity 'NATURALLY OCCURRING' named entity 'TYPE' named entity 'COMPLETELY' named entity 'MEDIATED' named entity 'MANNAN' named entity 'CENTRAL' named entity 'LSECTIN' named entity 'CD81' named entity 'OF LIVER DISEASE' named entity 'ENDOTHELIAL CELLS' named entity 'ECTODOMAIN' named entity 'CELLS' named entity 'ATTACHED' named entity 'FOUND' named entity 'INVOLVED' named entity 'INTERACT' named entity 'INFECTED' named entity 'MECHANISM' named entity 'SERA' named entity 'HEPATOCYTE' named entity 'VIRUS BINDING' named entity 'HEPATITIS C VIRUS' named entity 'STUDY' named entity 'DETAILED' named entity 'SINUSOIDAL' named entity 'CONTRIBUTE ' named entity 'LECTIN' named entity 'LSECTIN' named entity 'TYPE' named entity 'PREVIOUSLY' named entity 'BUT' named entity 'EXPRESSED' named entity 'RECEPTORS' named entity 'A MAJOR' named entity 'IDENTIFIED' named entity 'COULD BE' named entity 'PRESENT' named entity 'INHIBITED' named entity 'BINDING' named entity 'TREATMENT' named entity 'CAUSE' named entity 'INFECTION' named entity 'HEPATITIS C VIRUS' named entity 'DC-SIGNR' named entity 'HERE' named entity 'UNDERLYING' named entity 'INDIVIDUALS' named entity 'IS A' named entity 'NOVEL' named entity 'LECTIN' named entity 'EGTA' named entity 'LIVER' named entity 'GLYCOPROTEIN' named entity 'ITS' named entity 'DC-SIGNR' named entity 'UNDERSTOOD' covid:arg/14aae1385e314505aefe392e22d78bcf4f75f532 named entity 'glycoprotein' named entity 'hepatocyte' named entity 'mechanism' named entity 'attached' named entity 'binding' named entity 'C-type' named entity 'completely'

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