About: A reversible model of acute lung injury based on ozone exposure

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	A reversible model of acute lung injury based on ozone exposure
Creator	Bassett, D Elbon, C Kerr, J Reichenbaugh, S Bowen-Kellyfl, E Brewster, E Bunton, L
source	PMC
abstract	In this study inflammatory responses were determined in rat lungs 0, 1, 3, and 8 days following single 2- and 4-hr exposures to 1.8 ppm ozone. Analysis of lavage fluid immediately following exposure demonstrated enhanced lactate dehydrogenase activity and decreased numbers of lavageable macrophages but no alterations in albumin content. Similar analyses at one day postexposure demonstrated 282% and 456% increases in albumin content and enhanced numbers of lavageable neutrophils from a control value of 0.01 ± 0.01 to 0.27 ± 0.10 and 0.78 ± 0.11 million cells per lung for 2-hr and 4-hr exposures, respectively. The observed increased levels of albumin were also present at 3 days, at which time the number of lavageable neutrophils was not significantly different than control. At both one and 3 days postexposure, lavageable lymphocytes were significantly increased 10-fold from a control value of 0.03 ± 0.01 million cells per lung. However, the number of lavageable macrophages was unaltered on day 1, but enhanced on day 3, giving values of 0.67 ± 0.05 (control), 2.25 ± 0.46 (2 hr), and 2.70 ± 1.05 (4 hr) million cells per lung. By 8 days both inflammatory cell numbers and albumin levels had returned to control values. Since these data demonstrated different time courses for each inflammatory cell type, this reversible model of acute lung injury should be useful for establishing possible involvement of these cells in processes of lung injury.
has issue date	1988-01-01(xsd:dateTime)
bibo:doi	10.1007/bf02714068
bibo:pmid	3148794
has license	no-cc
sha1sum (hex)	14c50b8ad239f2077965314a9b87c16cb64bfa8b
schema:url	https://doi.org/10.1007/bf02714068
resource representing a document's title	A reversible model of acute lung injury based on ozone exposure
has PubMed Central identifier	PMC7087886
has PubMed identifier	3148794
schema:publication	Lung
resource representing a document's body	covid:14c50b8ad239f2077965314a9b87c16cb64bfa8b#body_text
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