About: Chicken interferome: avian interferon-stimulated genes identified by microarray and RNA-seq of primary chick embryo fibroblasts treated with a chicken type I interferon (IFN-α)

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About: Chicken interferome: avian interferon-stimulated genes identified by microarray and RNA-seq of primary chick embryo fibroblasts treated with a chicken type I interferon (IFN-α) Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Chicken interferome: avian interferon-stimulated genes identified by microarray and RNA-seq of primary chick embryo fibroblasts treated with a chicken type I interferon (IFN-α)
Creator	Giotis, Efstathios Skinner, Michael Goodbourn, Stephen Robey, Rebecca Skinner, Natalie Tomlinson, Christopher
Source	Medline; PMC
abstract	Viruses that infect birds pose major threats—to the global supply of chicken, the major, universally-acceptable meat, and as zoonotic agents (e.g. avian influenza viruses H5N1 and H7N9). Controlling these viruses in birds as well as understanding their emergence into, and transmission amongst, humans will require considerable ingenuity and understanding of how different species defend themselves. The type I interferon-coordinated response constitutes the major antiviral innate defence. Although interferon was discovered in chicken cells, details of the response, particularly the identity of hundreds of stimulated genes, are far better described in mammals. Viruses induce interferon-stimulated genes but they also regulate the expression of many hundreds of cellular metabolic and structural genes to facilitate their replication. This study focusses on the potentially anti-viral genes by identifying those induced just by interferon in primary chick embryo fibroblasts. Three transcriptomic technologies were exploited: RNA-seq, a classical 3′-biased chicken microarray and a high density, “sense target”, whole transcriptome chicken microarray, with each recognising 120–150 regulated genes (curated for duplication and incorrect assignment of some microarray probesets). Overall, the results are considered robust because 128 of the compiled, curated list of 193 regulated genes were detected by two, or more, of the technologies. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s13567-016-0363-8) contains supplementary material, which is available to authorized users.
has issue date	2016-08-05(xsd:dateTime)
bibo:doi	10.1186/s13567-016-0363-8
bibo:pmid	27494935
has license	cc-by
sha1sum (hex)	14d0201b350f8ecc80d016c75cf6335dc0afa85b
schema:url	https://doi.org/10.1186/s13567-016-0363-8
resource representing a document's title	Chicken interferome: avian interferon-stimulated genes identified by microarray and RNA-seq of primary chick embryo fibroblasts treated with a chicken type I interferon (IFN-α)
has PubMed Central identifier	PMC4974698
has PubMed identifier	27494935
schema:publication	Vet Res
resource representing a document's body	covid:14d0201b350f8ecc80d016c75cf6335dc0afa85b#body_text
is schema:about of	named entity 'interferon' named entity 'Viruses' named entity 'Chicken' named entity 'IFN-α' named entity 'chicken' named entity 'microarray' named entity 'IDENTITY' named entity 'FIBROBLASTS' named entity 'REGULATED' named entity 'CHICKEN' named entity 'DEFEND' named entity 'CELLULAR' named entity 'GENES' named entity 'OVERALL' named entity 'CLASSICAL' named entity 'TECHNOLOGIES' named entity 'regulated' named entity 'anti-viral' named entity 'exploited' named entity 'hundreds' named entity 'viruses' named entity 'cells' named entity 'H7N9' named entity 'microarray' named entity 'birds' named entity 'embryo' named entity 'metabolic' named entity 'type I interferon' named entity 'RNA-seq' named entity 'chicken' named entity 'zoonotic' named entity 'embryo' named entity 'chicken' named entity 'transcriptome' named entity 'microarray' named entity 'IFN' named entity 'chick embryo' named entity 'details' named entity 'Cytokines' named entity 'GAPDH' named entity 'RNA' named entity 'RNA-seq' named entity 'hect' named entity 'viruses' named entity 'Affymetrix' named entity 'qRT-PCR' named entity 'Illumina' named entity 'ISGs' named entity 'STAT1' named entity 'microarrays' named entity 'chicken' named entity 'flow cell' named entity 'upstream and downstream' named entity 'ultrastructural' named entity 'down-regulated' named entity 'Thermo Fisher Scientific' named entity 'IFN' named entity 'microarrays' named entity 'macrochromosomes' named entity 'ISG' named entity 'microarray' named entity 'polyadenylated' named entity 'chicken' named entity 'deep sequencing' named entity 'Genomic loci' named entity 'RNA' named entity 'SOCS1' named entity 'mixed model' named entity 'genome' named entity 'ISRE' named entity 'chromosome' named entity 'RNA integrity number' named entity 'RNA-seq' named entity 'Clinical Sciences' named entity 'ISGs' named entity 'RNA-seq'

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