About: Tamiflu-Resistant but HA-Mediated Cell-to-Cell Transmission through Apical Membranes of Cell-Associated Influenza Viruses

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Tamiflu-Resistant but HA-Mediated Cell-to-Cell Transmission through Apical Membranes of Cell-Associated Influenza Viruses Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Tamiflu-Resistant but HA-Mediated Cell-to-Cell Transmission through Apical Membranes of Cell-Associated Influenza Viruses
Creator	Haruyama, T Mori, K Nagata, K
source	PMC
abstract	The infection of viruses to a neighboring cell is considered to be beneficial in terms of evasion from host anti-virus defense systems. There are two pathways for viral infection to “right next door”: one is the virus transmission through cell-cell fusion by forming syncytium without production of progeny virions, and the other is mediated by virions without virus diffusion, generally designated cell-to-cell transmission. Influenza viruses are believed to be transmitted as cell-free virus from infected cells to uninfected cells. Here, we demonstrated that influenza virus can utilize cell-to-cell transmission pathway through apical membranes, by handover of virions on the surface of an infected cell to adjacent host cells. Live cell imaging techniques showed that a recombinant influenza virus, in which the neuraminidase gene was replaced with the green fluorescence protein gene, spreads from an infected cell to adjacent cells forming infected cell clusters. This type of virus spreading requires HA activation by protease treatment. The cell-to-cell transmission was also blocked by amantadine, which inhibits the acidification of endosomes required for uncoating of influenza virus particles in endosomes, indicating that functional hemagglutinin and endosome acidification by M2 ion channel were essential for the cell-to-cell influenza virus transmission. Furthermore, in the cell-to-cell transmission of influenza virus, progeny virions could remain associated with the surface of infected cell even after budding, for the progeny virions to be passed on to adjacent uninfected cells. The evidence that cell-to-cell transmission occurs in influenza virus lead to the caution that local infection proceeds even when treated with neuraminidase inhibitors.
has issue date	2011-11-30(xsd:dateTime)
bibo:doi	10.1371/journal.pone.0028178
bibo:pmid	22140536
has license	cc-by
sha1sum (hex)	15228615c1656f39a5ec8dcc8bc26ef0371d4040
schema:url	https://doi.org/10.1371/journal.pone.0028178
resource representing a document's title	Tamiflu-Resistant but HA-Mediated Cell-to-Cell Transmission through Apical Membranes of Cell-Associated Influenza Viruses
has PubMed Central identifier	PMC3227662
has PubMed identifier	22140536
schema:publication	PLoS One
resource representing a document's body	covid:15228615c1656f39a5ec8dcc8bc26ef0371d4040#body_text
is schema:about of	named entity 'TAMIFLU' named entity 'BUT' named entity 'APICAL' named entity 'neighboring' named entity 'host' named entity 'particles' named entity 'VIRUSES' named entity 'MEDIATED' named entity 'BLOCKED' named entity 'TYPE' named entity 'DOOR' named entity 'CELL' named entity 'TREATMENT' named entity 'PROTEIN GENE' named entity 'MEMBRANES' named entity 'RESISTANT' named entity 'UNCOATING' named entity 'NEURAMINIDASE' named entity 'SPREADING' named entity 'FREE' named entity 'APICAL' named entity 'INDICATING' named entity 'THE GREEN' named entity 'CAUTION' named entity 'CELL CLUSTERS' named entity 'BENEFICIAL' named entity 'INFLUENZA VIRUSES' named entity 'DEFENSE' named entity 'PROTEASE' named entity 'ENDOSOMES' named entity 'ACIDIFICATION' named entity 'LOCAL INFECTION' named entity 'INFECTED CELL' named entity 'CELL' named entity 'ASSOCIATED' named entity 'PRODUCTION' named entity 'IMAGING TECHNIQUES' named entity 'ENDOSOME ACIDIFICATION' named entity 'INFLUENZA VIRUS' named entity 'GENERALLY' named entity 'TRANSMISSION' named entity 'BUDDING' named entity 'TRANSMITTED' named entity 'LEAD' named entity 'CELL-CELL FUSION' named entity 'FLUORESCENCE PROTEIN' named entity 'RECOMBINANT' named entity 'HEMAGGLUTININ' named entity 'DESIGNATED' named entity 'HERE' named entity 'PASSED' named entity 'TRANSMISSION' named entity 'TERMS' named entity 'HOST' named entity 'MEDIATED' named entity 'PROGENY' named entity 'UNINFECTED' named entity 'LIVE CELL IMAGING' named entity 'PATHWAYS' named entity 'HANDOVER' named entity 'REQUIRED' named entity 'ACTIVATION' named entity 'PATHWAY' named entity 'VIRAL INFECTION' named entity 'CONSIDERED' named entity 'AMANTADINE' named entity 'NEURAMINIDASE INHIBITORS' named entity 'ASSOCIATED WITH' named entity 'SYNCYTIUM' named entity 'INFLUENZA VIRUSES' named entity 'DEMONSTRATED' named entity 'GREEN ' named entity 'INFECTED' named entity 'VIRIONS' named entity 'TREATED WITH' named entity 'EVIDENCE' named entity 'DIFFUSION' named entity 'ESSENTIAL' named entity 'FUNCTIONAL'

Faceted Search & Find service v1.13.91 as of Mar 24 2020

Alternative Linked Data Documents: Sponger | ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3229 as of Jul 10 2020, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (94 GB total memory)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2025 OpenLink Software