About: A Recombinant Newcastle Disease Virus (NDV) Expressing S Protein of Infectious Bronchitis Virus (IBV) Protects Chickens against IBV and NDV

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About: A Recombinant Newcastle Disease Virus (NDV) Expressing S Protein of Infectious Bronchitis Virus (IBV) Protects Chickens against IBV and NDV Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	A Recombinant Newcastle Disease Virus (NDV) Expressing S Protein of Infectious Bronchitis Virus (IBV) Protects Chickens against IBV and NDV
Creator	Paldurai, Anandan Shirvani, Edris Samal, Siba Varghese, Berin Manoharan, Vinoth
Source	PMC
abstract	Infectious bronchitis virus (IBV) causes a highly contagious respiratory, reproductive and urogenital tract disease in chickens worldwide, resulting in substantial economic losses for the poultry industry. Currently, live-attenuated IBV vaccines are used to control the disease. However, safety, attenuation and immunization outcomes of current vaccines are not guaranteed. Several studies indicate that attenuated IBV vaccine strains contribute to the emergence of variant viruses in the field due to mutations and recombination. Therefore, there is a need to develop a stable and safe IBV vaccine that will not create variant viruses. In this study, we generated recombinant Newcastle disease viruses (rNDVs) expressing the S1, S2 and S proteins of IBV using reverse genetics technology. Our results showed that the rNDV expressing the S protein of IBV provided better protection than the rNDV expressing S1 or S2 protein of IBV, indicating that the S protein is the best protective antigen of IBV. Immunization of 4-week-old SPF chickens with the rNDV expressing S protein elicited IBV-specific neutralizing antibodies and provided complete protection against virulent IBV and virulent NDV challenges. These results suggest that the rNDV expressing the S protein of IBV is a safe and effective bivalent vaccine candidate for both IBV and NDV.
has issue date	2018-08-10(xsd:dateTime)
bibo:doi	10.1038/s41598-018-30356-2
bibo:pmid	30097608
has license	cc-by
sha1sum (hex)	1579fbff7af9b156c6f49fee0526e48f852ea460
schema:url	https://doi.org/10.1038/s41598-018-30356-2
resource representing a document's title	A Recombinant Newcastle Disease Virus (NDV) Expressing S Protein of Infectious Bronchitis Virus (IBV) Protects Chickens against IBV and NDV
has PubMed Central identifier	PMC6086832
has PubMed identifier	30097608
schema:publication	Sci Rep
resource representing a document's body	covid:1579fbff7af9b156c6f49fee0526e48f852ea460#body_text
is schema:about of	named entity 'current' named entity 'recombinant' named entity 'expressing' named entity 'expressing' named entity 'protein' named entity 'NDV' named entity 'IBV' named entity 'Newcastle' covid:arg/1579fbff7af9b156c6f49fee0526e48f852ea460 named entity 'neutralizing antibodies' named entity 'IBV' named entity 'study' named entity 'bivalent' named entity 'Bronchitis' named entity 'viruses' named entity 'viruses' named entity 'IBV' named entity 'protein' named entity 'vaccines' named entity 'protein' named entity 'Immunization' named entity 'Recombinant' named entity 'IBV' named entity 'protein' named entity 'dyspnea' named entity 'clinical signs' named entity 'allantoic' named entity 'Kozak' named entity 'gene' named entity 'serine' named entity 'S protein' named entity 'viruses' named entity 'IBV' named entity 'fetal bovine serum' named entity 'IBV' named entity 'serine' named entity 'vaccine' named entity 'protein' named entity 'serine' named entity 'protein' named entity 'N-terminus' named entity 'epitopes' named entity 'immune response' named entity 'IBV' named entity 'plasmids' named entity 'RT-PCR' named entity 'serine' named entity 'IBV' named entity 'assay' named entity 'NDV' named entity 'serine' named entity 'gene' named entity 'nasal discharge' named entity 'protein' named entity 'kDa' named entity 'difficulty in breathing' named entity 'NDV' named entity 'antigen' named entity 'ANOVA' named entity 'serine' named entity 'transmembrane' named entity 'gene' named entity 'protein' named entity 'protein' named entity 'virulent' named entity 'serum samples' named entity 'cell lysates' named entity 'DMEM' named entity 'virulent' named entity 'serine' named entity 'trachea' named entity 'codon' named entity 'PBS' named entity 'animal experiments' named entity 'protein' named entity 'IBV' named entity 'gene'

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