About: A crucial role of angiotensin converting enzyme 2 (ACE2) in SARS coronavirus

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About: A crucial role of angiotensin converting enzyme 2 (ACE2) in SARS coronavirus–induced lung injury Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	A crucial role of angiotensin converting enzyme 2 (ACE2) in SARS coronavirus–induced lung injury
Creator	Yang, Peng Imai, Yumiko Kuba, Keiji Jiang, Chengyu Guo, Feng Qin, Chuan Liu, Guang Gao, Hong Wang, Zhong Zhang, Yanli Zheng, Dexian Bao, Linlin Rao, Shuan Deng, Wei Chappell, Mark Guan, Bin Huan, Yi Leibbrandt, Andreas Liu, Depei Liu, Yanxin Penninger, Josef Slutsky, Arthur Wada, Teiji Zhang, Binlin
Source	Medline; PMC
abstract	During several months of 2003, a newly identified illness termed severe acute respiratory syndrome (SARS) spread rapidly through the world(1,2,3). A new coronavirus (SARS-CoV) was identified as the SARS pathogen(4,5,6,7), which triggered severe pneumonia and acute, often lethal, lung failure(8). Moreover, among infected individuals influenza such as the Spanish flu(9,10) and the emergence of new respiratory disease viruses(11,12) have caused high lethality resulting from acute lung failure(13). In cell lines, angiotensin-converting enzyme 2 (ACE2) has been identified as a potential SARS-CoV receptor(14). The high lethality of SARS-CoV infections, its enormous economic and social impact, fears of renewed outbreaks as well as the potential misuse of such viruses as biologic weapons make it paramount to understand the pathogenesis of SARS-CoV. Here we provide the first genetic proof that ACE2 is a crucial SARS-CoV receptor in vivo. SARS-CoV infections and the Spike protein of the SARS-CoV reduce ACE2 expression. Notably, injection of SARS-CoV Spike into mice worsens acute lung failure in vivo that can be attenuated by blocking the renin-angiotensin pathway. These results provide a molecular explanation why SARS-CoV infections cause severe and often lethal lung failure and suggest a rational therapy for SARS and possibly other respiratory disease viruses. SUPPLEMENTARY INFORMATION: The online version of this article (doi:10.1038/nm1267) contains supplementary material, which is available to authorized users.
has issue date	2005-07-10(xsd:dateTime)
bibo:doi	10.1038/nm1267
bibo:pmid	16007097
has license	no-cc
sha1sum (hex)	1596ce185642a780f3bde1399ef49e70ea91da55
schema:url	https://doi.org/10.1038/nm1267
resource representing a document's title	A crucial role of angiotensin converting enzyme 2 (ACE2) in SARS coronavirus–induced lung injury
has PubMed Central identifier	PMC7095783
has PubMed identifier	16007097
schema:publication	Nat Med
resource representing a document's body	covid:1596ce185642a780f3bde1399ef49e70ea91da55#body_text
is schema:about of	named entity 'cell lines' named entity 'viruses' named entity 'triggered' named entity 'acute' named entity 'enzyme' named entity 'GENETIC' named entity 'IN VIVO' named entity 'PROVIDE' named entity 'IDENTIFIED' named entity 'MONTHS' named entity 'PATHOGENESIS' named entity 'BIOLOGIC' named entity 'RESPIRATORY DISEASE' named entity 'INDIVIDUALS' named entity 'CAUSED' named entity 'ACUTE' named entity 'FAILURE' named entity 'SARS' named entity 'HERE' named entity 'SEVERE ACUTE RESPIRATORY SYNDROME' named entity 'LUNG' named entity 'CELL LINES' named entity 'LUNG INJURY' named entity 'ROLE' named entity 'INDUCED' named entity 'SARS CORONAVIRUS' named entity 'ANGIOTENSIN CONVERTING ENZYME 2' named entity 'ITS' named entity 'VIRUSES' named entity 'MISUSE' named entity 'RESULTING FROM' named entity 'NEW' named entity 'ACE2' named entity 'LETHAL' named entity 'MAKE' named entity 'SARS-COV' named entity 'RECEPTOR' named entity 'INFECTED' named entity 'IS A' named entity 'LETHALITY' named entity 'WEAPONS' named entity 'UNDERSTAND' named entity 'ECONOMIC' named entity 'NEWLY' named entity 'CORONAVIRUS' named entity 'ANGIOTENSIN-CONVERTING ENZYME 2' named entity 'EMERGENCE' named entity 'PATHOGEN' named entity 'RAPIDLY' named entity 'OUTBREAKS' named entity 'HIGH' named entity 'SPREAD' named entity 'POTENTIAL' named entity 'SEVERE PNEUMONIA' named entity 'FEARS' named entity 'HAVE' named entity 'SPANISH FLU' named entity 'TRIGGERED'

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