About: Near-patient assays for diagnosis of influenza virus infection in adult patients

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Near-patient assays for diagnosis of influenza virus infection in adult patients
Creator	Popow-Kraupp, T Graninger, W Kundi, M Redlberger, M Steininger, C
Source	Elsevier; Medline; PMC
abstract	Rapid and reliable diagnosis of influenza is essential for identification of contagious patients and effective patient management. Near-patient assays allow establishment of the diagnosis within minutes in young children, and this study aimed to evaluate near-patient assays in relation to the patient’s age. A total of 194 patients with laboratory-confirmed influenza A/H3N2 virus infection, diagnosed within a prospective cohort study, were included. Cryopreserved nasopharyngeal swabs collected from these patients were tested by four near-patient assays (Binax Now Influenza A&B, Quick S-Influ A/B, Influ-A&B Respi-Strip, and Actim Influenza A&B). The main outcome measure was sensitivity of the near-patient assays in relation to the age of patients. The Binax Now, Quick S-Influ, Influ-A&B Respi-Strip and Actim assays had overall sensitivities of 19%, 18%, 26%, and 40%, respectively. The estimated sensitivity for influenza A/H3N2 virus detection in nasopharyngeal swabs was 17–56% in children 1 year of age and decreased to 8–22% in patients 80 years of age (logistic regression). The sensitivity of the Influ-A&B Respi-Strip and Actim assays decreased significantly with increasing age (p 0.014 and p 0.033, respectively (logistic regression)), a trend for decrease was observed for the Binax Now assay (p 0.074 (logistic regression)), and the low sensitivity of the Quick S-Influ assay was similar in children and adults. Less than one-fourth of diagnosed influenza A/H3N2 virus infections can be identified in elderly patients using a near-patient assay. Consequently, near-patient assays are of limited value for confirming the diagnosis when influenza is clinically suspected in adults. Antiviral therapy and additional diagnostic procedures cannot be withheld on the basis of a negative near-patient assay result, particularly in adult patients.
has issue date	2014-12-12(xsd:dateTime)
bibo:doi	10.1111/j.1469-0691.2008.02674.x
bibo:pmid	19183404
has license	no-cc
sha1sum (hex)	15998c56cbc9d5def9fed655e7b0263f97fbddf5
schema:url	https://doi.org/10.1111/j.1469-0691.2008.02674.x
resource representing a document's title	Near-patient assays for diagnosis of influenza virus infection in adult patients
has PubMed Central identifier	PMC7128506
has PubMed identifier	19183404
schema:publication	Clin Microbiol Infect
resource representing a document's body	covid:15998c56cbc9d5def9fed655e7b0263f97fbddf5#body_text
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