About: A rapid and sensitive method to detect SARS-CoV-2 virus using targeted-mass spectrometry

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About: A rapid and sensitive method to detect SARS-CoV-2 virus using targeted-mass spectrometry Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	A rapid and sensitive method to detect SARS-CoV-2 virus using targeted-mass spectrometry
Creator	Agrawal, Anurag Singh, Priyanka Dash, Debasis Chakraborty, Dhar, Mahesh Dutta, Meena Garg, Parth Gogia, Hema Imran, Mohamed Kabra, Sandhya Kumar Bhaskar, Akash Kumar, Pramod Lall, Hemlata Madan, Preeti Pradhan, Shalini Raj, Anurag Rakhit, Partha Rakshit, Partha Ranjan, Gyan Ray, Arjun Sengupta, Shantanu Sharma, Uma Sivasubbu, Sridhar Singh, Sujeet Singh, Praveen Vashisht, Himanshu
Source	MedRxiv
abstract	In the last few months, there has been a global catastrophic outbreak of severe acute respiratory syndrome disease caused by the novel corona virus SARS-CoV-2 affecting millions of people worldwide. Early diagnosis and isolation is key to contain the rapid spread of the virus. Towards this goal, we report a simple, sensitive and rapid method to detect the virus using a targeted mass spectrometric approach, which can directly detect the presence of virus from naso-oropharyngeal swabs. Using a multiple reaction monitoring we can detect the presence of two peptides specific to SARS-CoV-2 in a 2.3 minute gradient run with 100% specificity and 90.4 % sensitivity when compared to RT-PCR. Importantly, we further show that these peptides could be detected even in the patients who have recovered from the symptoms and have tested negative for the virus by RT-PCR highlighting the sensitivity of the technique. This method has the translational potential of in terms of the rapid diagnostics of symptomatic and asymptomatic COVID-19 and can augment current methods available for diagnosis of SARS-CoV-2.
has issue date	2020-07-29(xsd:dateTime)
bibo:doi	10.1101/2020.07.27.20161836
has license	medrxiv
sha1sum (hex)	15b1632fa1176588068f8976fe9ec5dd1ad46173
schema:url	https://doi.org/10.1101/2020.07.27.20161836
resource representing a document's title	A rapid and sensitive method to detect SARS-CoV-2 virus using targeted-mass spectrometry
resource representing a document's body	covid:15b1632fa1176588068f8976fe9ec5dd1ad46173#body_text
is schema:about of	named entity 'SARS-CoV-2' named entity 'recovered' named entity 'rapid' named entity 'catastrophic' named entity 'RAPID' named entity 'SENSITIVITY' named entity 'METHODS' named entity 'PEOPLE' named entity 'rapid' named entity 'diagnosis' named entity 'peptides' named entity 'outbreak' named entity 'RT-PCR' named entity 'Early diagnosis' named entity 'RT-PCR' named entity 'multiple reaction monitoring' named entity 'asymptomatic' named entity 'severe acute respiratory syndrome' named entity 'virus' named entity 'mass spectrometry' named entity 'sensitivity' named entity 'Mass spectrometer' named entity 'peptides' named entity 'preprint' named entity 'peptides' named entity 'peptides' named entity 'protein' named entity 'virus' named entity 'false discovery rate' named entity 'peptides' named entity 'SARS CoV' named entity 'peptides' named entity 'antibodies' named entity 'medRxiv' named entity 'UPLC' named entity 'AB Sciex' named entity 'SARS-CoV-2' named entity 'peptides' named entity 'COVID' named entity 'asymptomatic' named entity 'protein sequences' named entity 'sequence homology' named entity 'peptide' named entity 'peptide' named entity 'BLAST search' named entity 'Cysteine' named entity 'peptides' named entity 'antigen' named entity 'peptides' named entity 'serum albumin' named entity 'RT-PCR' named entity 'preprint' named entity 'medRxiv' named entity 'peptides' named entity 'nebulizer' named entity 'peptides' named entity 'preprint' named entity 'RT-PCR' named entity 'antibodies' named entity '10.5'

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