About: CD163(+)CD204(+) tumor-associated macrophages contribute to T cell regulation via interleukin-10 and PD-L1 production in oral squamous cell carcinoma

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About: CD163(+)CD204(+) tumor-associated macrophages contribute to T cell regulation via interleukin-10 and PD-L1 production in oral squamous cell carcinoma Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	CD163(+)CD204(+) tumor-associated macrophages contribute to T cell regulation via interleukin-10 and PD-L1 production in oral squamous cell carcinoma
Creator	Furukawa, Sachiko Hayashida, Jun-Nosuke Ishiguro, Noriko Jinno, Teppei Kawano, Shintaro Kiyoshima, Tamotsu Kubota, Keigo Maehara, Takashi Maruse, Yasuyuki Moriyama, Masafumi Nakamura, Seiji Ohta, Miho Sakamoto, Mizuki Tanaka, Akihiko Yamauchi, Masaaki Rafiul, Haque
Source	PMC
abstract	Tumor-associated macrophages (TAMs) promote cancer cell proliferation, invasion, and metastasis by producing various mediators. Although preclinical studies demonstrated that TAMs preferentially express CD163 and CD204, the TAM subsets in oral squamous cell carcinoma (OSCC) remain unknown. In this study, we examined the expression and role of TAM subsets in OSCC. Forty-six patients with OSCC were analyzed for expression of TAMs in biopsy samples by immunohistochemistry. We examined TAM subsets and their production of immune suppressive molecules (IL-10 and PD-L1) in peripheral blood mononuclear cells from three OSCC patients by flow cytometry. CD163 was detected around the tumor or connective tissue, while CD204 was detected in/around the tumors. Flow cytometric analysis revealed that CD163(+)CD204(+) TAMs strongly produced IL-10 and PD-L1 in comparison with CD163(+)CD204(−) and CD163(−)CD204(+) TAMs. Furthermore, the number of activated CD3(+) T cells after co-culture with CD163(+)CD204(+) TAMs was significantly lower than that after co-culture with other TAM subsets. In clinical findings, the number of CD163(+)CD204(+) TAMs was negatively correlated with that of CD25(+) cells and 5-year progression-free survival. These results suggest that CD163(+)CD204(+) TAMs possibly play a key role in the invasion and metastasis of OSCC by T-cell regulation via IL-10 and PD-L1 production.
has issue date	2017-05-11(xsd:dateTime)
bibo:doi	10.1038/s41598-017-01661-z
bibo:pmid	28496107
has license	cc-by
sha1sum (hex)	15ca0457de2d05a3796f024899edc9c55c86e4ba
schema:url	https://doi.org/10.1038/s41598-017-01661-z
resource representing a document's title	CD163(+)CD204(+) tumor-associated macrophages contribute to T cell regulation via interleukin-10 and PD-L1 production in oral squamous cell carcinoma
has PubMed Central identifier	PMC5431876
has PubMed identifier	28496107
schema:publication	Sci Rep
resource representing a document's body	covid:15ca0457de2d05a3796f024899edc9c55c86e4ba#body_text
is schema:about of	named entity 'T CELL' named entity 'expression' named entity 'TAMs' named entity 'regulation' named entity 'samples' named entity 'production' named entity 'PD-L1' named entity 'BIOPSY' covid:arg/15ca0457de2d05a3796f024899edc9c55c86e4ba named entity 'ORAL SQUAMOUS CELL CARCINOMA' named entity 'CD204' named entity 'PD-L1' named entity 'INTERLEUKIN-10 ' named entity 'IMMUNOHISTOCHEMISTRY' named entity 'YEAR' named entity 'PRODUCTION' named entity 'CONNECTIVE TISSUE' named entity 'CD25' named entity 'T CELLS' named entity 'THESE' named entity 'FORTY' named entity 'PRODUCTION' named entity 'REGULATION' named entity 'IMMUNE' named entity 'TAM' named entity 'SUGGEST' named entity 'PLAY' named entity 'THEIR' named entity 'PERIPHERAL BLOOD MONONUCLEAR CELLS' named entity 'CONTRIBUTE ' named entity 'REGULATION' named entity 'ASSOCIATED' named entity 'TUMOR' named entity 'CD163' named entity 'CELLS' named entity 'SUPPRESSIVE' named entity 'METASTASIS' named entity 'CO-CULTURE' named entity 'ACTIVATED' named entity 'ANALYZED' named entity 'CD204' named entity 'EXPRESSION' named entity 'OSCC' named entity 'STUDY' named entity 'RESULTS' named entity 'SAMPLES' named entity 'EXAMINED' named entity 'POSSIBLY' named entity 'CORRELATED' named entity 'DETECTED' named entity 'NUMBER OF' named entity 'CD3' named entity 'CLINICAL FINDINGS' named entity 'CD163' named entity 'MOLECULES' named entity 'T-CELL' named entity 'PATIENTS' named entity 'PROGRESSION-FREE SURVIVAL' named entity 'IL-10' named entity 'FLOW CYTOMETRY' named entity 'TUMOR' named entity 'ROLE' named entity 'OPEN' named entity 'MACROPHAGES' named entity 'INVASION' named entity 'KEY'

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