About: Studying neuroprotective effect of Atorvastatin as a small molecule drug on high glucose-induced neurotoxicity in undifferentiated PC12 cells: role of NADPH oxidase

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About: Studying neuroprotective effect of Atorvastatin as a small molecule drug on high glucose-induced neurotoxicity in undifferentiated PC12 cells: role of NADPH oxidase Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Studying neuroprotective effect of Atorvastatin as a small molecule drug on high glucose-induced neurotoxicity in undifferentiated PC12 cells: role of NADPH oxidase
Creator	Dehpour, Ahmad Rayegan, Samira Sharifi, Ali
topic	covid:15cb85573f9951cd1d647e3744c7be4d8fedf846#this
source	PMC
abstract	Overproduction of reactive oxygen species (ROS) by NADPH oxidase (NOX) activation has been considered the essential mechanism induced by hyperglycemia in various tissues. However, there is no comprehensive study on the role of NOXs in high glucose (HG)-induced toxic effect in neural tissues. Recently, a therapeutic strategy in oxidative related pathologies has been introduced by blocking the undesirable actions of NOX enzymes by small molecules. The protective roles of Statins in ameliorating oxidative stress by NOX inhibition have been shown in some tissues except neural. We hypothesized then, that different NOXs may have role in HG-induced neural cell injury. Furthermore, we postulate that Atorvastatin as a small molecule may modulate this NOXs activity to protect neural cells. Undifferentiated PC12 cells were treated with HG (140 mM/24 h) in the presence and absence of Atorvastatin (1 μM/96 h). The cell viability was measured by MTT assay and the gene and protein expressions profile of NOX (1–4) were determined by RT-PCR and western blotting, respectively. Levels of ROS and malondialdehyde (MDA) were also evaluated. Gene and protein expression levels of NOX (1–4) and consequently ROS and MDA levels were elevated in HG-treated PC12 cells. Atorvastatin could significantly decrease HG-induced NOXs, ROS and MDA elevation and improve impaired cell viability. It can be concluded that HG could elevate NOXs activity, ROS and MDA levels in neural tissues and Atorvastatin as a small molecule NOX inhibitor drug may prevent and delay diabetic complications, particularly neuropathy.
has issue date	2016-08-01(xsd:dateTime)
bibo:doi	10.1007/s11011-016-9883-1
bibo:pmid	27476541
has license	no-cc
sha1sum (hex)	15cb85573f9951cd1d647e3744c7be4d8fedf846
schema:url	https://doi.org/10.1007/s11011-016-9883-1
resource representing a document's title	Studying neuroprotective effect of Atorvastatin as a small molecule drug on high glucose-induced neurotoxicity in undifferentiated PC12 cells: role of NADPH oxidase
has PubMed Central identifier	PMC7102122
has PubMed identifier	27476541
schema:publication	Metab Brain Dis
resource representing a document's body	covid:15cb85573f9951cd1d647e3744c7be4d8fedf846#body_text
is http://vocab.deri.ie/void#inDataset of	https://covidontheweb.inria.fr:4443/about/id/http/ns.inria.fr/covid19/15cb85573f9951cd1d647e3744c7be4d8fedf846
is schema:about of	named entity 'neural cell' named entity 'Atorvastatin' named entity 'prevent' named entity 'modulate' named entity 'actions' named entity 'levels' named entity 'high' named entity 'Atorvastatin' named entity 'small molecule drug' named entity 'HAVE' named entity 'PATHOLOGIES' named entity 'SMALL MOLECULE' named entity 'NEURAL TISSUES' named entity 'A N' named entity 'OXIDATIVE STRESS' named entity 'ROS' named entity 'TREATED' named entity 'ELEVATION' named entity 'STUDY' named entity 'EVALUATED' named entity 'DECREASE' named entity 'VARIOUS' named entity 'WESTE' named entity 'TREATED WITH' named entity 'ACTIVATION' named entity 'THERAPEUTIC' named entity 'SMALL MOLECULES' named entity 'PROFILE' named entity 'NOX' named entity 'NADPH oxidase' named entity 'tissues' named entity 'ROS' named entity 'neural' named entity 'Atorvastatin' named entity 'However' named entity 'determined' named entity 'reactive oxygen species' named entity 'neural tissues' named entity 'Atorvastatin' named entity 'NOX' named entity 'MTT assay' named entity 'neural tissues' named entity 'ROS' named entity 'NOX' named entity 'RT-PCR' named entity 'ROS' named entity 'Statins' named entity 'improve' named entity 'Fermentas' named entity 'Atorvastatin' named entity 'glucose' named entity 'Atorvastatin' named entity 'PC12 cells' named entity 'streptomycin' named entity 'Bösel' named entity 'glucose' named entity 'transforming growth factor beta' named entity 'myocardium' named entity 'diabetic retinopathy' named entity 'Atorvastatin' named entity 'Atorvastatin' named entity 'NOX' named entity 'hexosamine' named entity 'mRNA' named entity 'pleiotropic effects' named entity 'PC12' named entity 'NOX4' named entity 'endothelial cells' named entity 'DMEM' named entity 'NOX' named entity 'Merelbeke' named entity 'osmotic' named entity 'NOX' named entity 'redox signaling' named entity 'PC12 cells' named entity 'traumatic amputation' named entity 'neuronal cells'

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