About: SARS-Cov-2-, HIV-1-, Ebola-neutralizing and anti-PD1 clones are predisposed

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	SARS-Cov-2-, HIV-1-, Ebola-neutralizing and anti-PD1 clones are predisposed
Creator	Zhu, Yan Wei, Lai Yang, Wei Zhang, Yanfang Ren, Jian Wang, Chengrui Zhang, Zhenhai Wu, Jiaqi Zhang, Chen, Yuan Chang, Changqing Guan, Junjie Guo, Shixin Lan, Chunhong Ma, Cuiyu Tang, Haipei Wang, Minhui Wang, Qilong Xie, Wenxi Xu, Qingxian Yang, Xiujia Yu, Xueqing Zeng, Huikun Zhang, Yanxia
source	BioRxiv
abstract	Antibody repertoire refers to the totality of the superbly diversified antibodies within an individual to cope with the vast array of possible pathogens. Despite this extreme diversity, antibodies of the same clonotype, namely public clones, have been discovered among individuals. Although some public clones could be explained by antibody convergence, public clones in naïve repertoire or virus-neutralizing clones from not infected people were also discovered. All these findings indicated that public clones might not occur by random and they might exert essential functions. However, the frequencies and functions of public clones in a population have never been studied. Here, we integrated 2,449 Rep-seq datasets from 767 donors and discovered 5.07 million public clones – ~10% of the repertoire are public in population. We found 38 therapeutic clones out of 3,390 annotated public clones including anti-PD1 clones in healthy people. Moreover, we also revealed clones neutralizing SARS-CoV-2, Ebola, and HIV-1 viruses in healthy individuals. Our result demonstrated that these clones are predisposed in the human antibody repertoire and may exert critical functions during particular immunological stimuli and consequently benefit the donors. We also implemented RAPID – a Rep-seq Analysis Platform with Integrated Databases, which may serve as a useful tool for others in the field.
has issue date	2020-08-18(xsd:dateTime)
bibo:doi	10.1101/2020.08.13.249086
has license	biorxiv
sha1sum (hex)	15d6e95127790774289f3f17c4a4363b8d9adc1f
schema:url	https://doi.org/10.1101/2020.08.13.249086
resource representing a document's title	SARS-Cov-2-, HIV-1-, Ebola-neutralizing and anti-PD1 clones are predisposed
schema:publication	bioRxiv
resource representing a document's body	covid:15d6e95127790774289f3f17c4a4363b8d9adc1f#body_text
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