About: Specific localisation of ions in bacterial membranes unravels physical mechanism of effective bacteria killing by sanitiser

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About: Specific localisation of ions in bacterial membranes unravels physical mechanism of effective bacteria killing by sanitiser Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Specific localisation of ions in bacterial membranes unravels physical mechanism of effective bacteria killing by sanitiser
Creator	Kaufmann, Stefan Abuillan, Wasim Brandenburg, Klaus Furikado, Ippei Gierlich, Simone Gutsmann, Thomas Habe, Taichi Inoue, Shigeto Konovalov, Oleg Tanaka, Motomu Thoma, Judith Yamamoto, Akihisa
Source	Medline; PMC
abstract	Antimicrobial resistance is a major threat to public health. Although many commercial sanitisers contain a combination of cationic surfactants and aromatic alcohols, the physical mechanisms where these two substances bind to or how they disturb bacterial membranes are still largely unknown. In this study, we designed a well-defined model of Gram-negative bacteria surfaces based on the monolayer of lipopolysaccharides with uniform saccharide head groups. Since commonly used X-ray reflectivity is sensitive to changes in the thickness, roughness and electron density but is not sensitive to elements, we employed grazing incidence X-ray fluorescence. In the absence of Ca(2+), cationic surfactants can penetrate into the membrane core with no extra support by disturbing the layer of K(+) coupled to negatively charged saccharide head group at z = 17 Å from the air/chain interface. On the other hand, Ca(2+) confined at z = 19 Å crosslink charged saccharides and prevent the incorporation of cationic surfactants. We found that the addition of nonlethal aromatic alcohols facilitate the incorporation of cationic surfactants by the significant roughening of the chain/saccharide interface. Combination of precise localisation of ions and molecular-level structural analysis quantitatively demonstrated the synegtestic interplay of ingredients to achieve a high antibacterial activity.
has issue date	2020-07-23(xsd:dateTime)
bibo:doi	10.1038/s41598-020-69064-1
bibo:pmid	32704045
has license	cc-by
sha1sum (hex)	15db98d872687c956b4f37b20d5d1dff4bcd1da7
schema:url	https://doi.org/10.1038/s41598-020-69064-1
resource representing a document's title	Specific localisation of ions in bacterial membranes unravels physical mechanism of effective bacteria killing by sanitiser
has PubMed Central identifier	PMC7378190
has PubMed identifier	32704045
schema:publication	Sci Rep
resource representing a document's body	covid:15db98d872687c956b4f37b20d5d1dff4bcd1da7#body_text
is schema:about of	named entity 'incidence' named entity 'electron density' named entity 'commonly' named entity 'alcohols' named entity 'addition' named entity 'mechanisms' named entity 'saccharides' named entity 'employed' named entity 'membranes' named entity 'THICKNESS' named entity 'SENSITIVE TO' named entity 'ACTIVITY' named entity 'LIPOPOLYSACCHARIDES' named entity 'HOW' named entity 'BASED' named entity 'USED' named entity 'LAYER' named entity 'FOUND' named entity 'INTERFACE' named entity 'public health' named entity 'aromatic' named entity 'quantitatively' named entity 'cationic surfactants' named entity 'interface' named entity 'localisation' named entity 'alcohols' named entity 'saccharide' named entity 'aromatic' named entity 'saccharide' named entity 'aromatic' named entity 'antibacterial activity' named entity 'Antimicrobial resistance' named entity 'alcohols' named entity 'cationic surfactants' named entity 'ions' named entity 'saccharide' named entity 'X-ray fluorescence' named entity 'LPS' named entity 'Lipid' named entity 'National Institute of Technology' named entity 'Sweden' named entity 'negatively charged' named entity 'surfactants' named entity '37 °C' named entity 'petroleum ether' named entity 'maximum concentration' named entity 'positive control' named entity 'Salmonella enterica' named entity 'saccharides' named entity 'benzyl alcohol' named entity 'bacteria' named entity 'CFU' named entity 'XRR' named entity 'XRR' named entity 'polysaccharide' named entity 'Japan' named entity 'solvent' named entity 'benzalkonium chloride' named entity 'bacteria' named entity 'grazing incidence' named entity 'XRR' named entity 'monolayer' named entity 'monovalent' named entity 'Grenoble' named entity 'XRR' named entity 'serovar' named entity 'LPS' named entity 'alcohols' named entity 'cell membranes' named entity 'head group'

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