About: PKR mediated regulation of inflammation and IL-10 during viral encephalomyelitis

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About: PKR mediated regulation of inflammation and IL-10 during viral encephalomyelitis Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	PKR mediated regulation of inflammation and IL-10 during viral encephalomyelitis
Creator	Kapil, Parul Bergmann, Cornelia Hinton, David Stohlman, Stephen
Source	Elsevier; Medline; PMC
abstract	Double-stranded RNA-dependent protein kinase (PKR) regulates antiviral activity, immune responses, apoptosis and neurotoxicity. Gliatropic coronavirus infection induced PKR activation in infected as well uninfected cells within the central nervous system (CNS). However, PKR deficiency only modestly increased viral replication and did not affect IFN-α/β or IL-1β expression. Despite reduced Il-6, Ccl5, and Cxcl10 mRNA, protein levels remained unaltered. Furthermore, PKR deficiency selectively reduced IL-10 production in CD4, but not CD8 T cells, without affecting CNS pathology. The results demonstrate the ability of PKR to balance neuroinflammation by selectively modulating key cytokines and chemokines in CNS resident and CD4 T cells.
has issue date	2014-05-01(xsd:dateTime)
bibo:doi	10.1016/j.jneuroim.2014.02.012
bibo:pmid	24642385
has license	green-oa
sha1sum (hex)	15ebc5b2e06803c4c06775cd751eff6ae2632e9a
schema:url	https://doi.org/10.1016/j.jneuroim.2014.02.012
resource representing a document's title	PKR mediated regulation of inflammation and IL-10 during viral encephalomyelitis
has PubMed Central identifier	PMC4019976
has PubMed identifier	24642385
schema:publication	Journal of Neuroimmunology
resource representing a document's body	covid:15ebc5b2e06803c4c06775cd751eff6ae2632e9a#body_text
is schema:about of	named entity 'REGULATION' named entity 'induced' named entity 'Ccl5' named entity 'chemokines' named entity 'RESIDENT' named entity 'AFFECTING' named entity 'T CELLS' named entity 'DEFICIENCY' named entity 'CENTRAL NERVOUS SYSTEM' named entity 'BUT' named entity 'IL-6' named entity 'RESULTS' named entity 'UNINFECTED' named entity 'DEPENDENT' named entity 'CXCL10' named entity 'IFN' named entity 'NEUROINFLAMMATION' named entity 'IL-10 PRODUCTION' named entity 'ABILITY' named entity 'MRNA' named entity 'PROTEIN LEVELS' named entity 'INCREASED' named entity 'PATHOLOGY' named entity 'CCL5' named entity 'MODULATING' named entity 'NEUROTOXICITY' named entity 'CNS' named entity 'PKR' named entity 'DID' named entity 'VIRAL REPLICATION' named entity 'APOPTOSIS' named entity 'PKR' named entity 'IL-10' named entity 'ENCEPHALOMYELITIS' named entity 'VIRAL' named entity 'INFLAMMATION' named entity 'MEDIATED' named entity 'CORONAVIRUS INFECTION' named entity 'IMMUNE RESPONSES' named entity 'CELLS' named entity 'PROTEIN KINASE' named entity 'ACTIVATION' named entity 'BALANCE' named entity 'EXPRESSION' named entity 'KEY' named entity 'CD8' named entity 'REDUCED' named entity 'IL-1' named entity 'CHEMOKINES' named entity 'CYTOKINES' named entity 'INFECTION INDUCED' named entity 'CD4' named entity 'UNALTERED' named entity 'DOUBLE-STRANDED RNA' named entity 'AFFECT' named entity 'INFECTED' named entity 'ANTIVIRAL ACTIVITY' covid:arg/15ebc5b2e06803c4c06775cd751eff6ae2632e9a named entity 'regulates' named entity 'reduced' named entity 'PKR' named entity 'However' named entity 'cells' named entity 'expression' named entity 'apoptosis' named entity 'PKR' named entity 'modulating' named entity 'CD4' named entity 'viral replication' named entity 'remained' named entity 'antiviral activity' named entity 'protein kinase' named entity 'pathology' named entity 'IL-10' named entity 'central nervous' named entity 'CNS' named entity 'chemokines' named entity 'IL-1β'

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