About: Robust ACE2 protein expression localizes to the motile cilia of the respiratory tract epithelia and is not increased by ACE inhibitors or angiotensin receptor blockers

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About: Robust ACE2 protein expression localizes to the motile cilia of the respiratory tract epithelia and is not increased by ACE inhibitors or angiotensin receptor blockers Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Robust ACE2 protein expression localizes to the motile cilia of the respiratory tract epithelia and is not increased by ACE inhibitors or angiotensin receptor blockers
Creator	Tsay, Gregory Nolan, Garry Hwang, Peter Jiang, Sizun Mcilwain, David Patel, Zara Yang, Angela Bau, Da-Tian Borchard, Nicole Chu, Pauline Dholakia, Sachi Gall, Phillip Goltsev, Yury Jackson, Peter Kanie, Tomoharu Kim, Dayoung Kim, Raymond Lee, Ivan Liao, Chun-Kang Lin, Chia-Der Lin, Chih-Feng Lin, Yi-Tsen Nakayama, Tsuguhisa Nayak, Jayakar Overdevest, Jonathan Phillips, Katie Schürch, Christian Shih, Liang-Chun Tai, Chih-Jaan Tsai, Ming-Hsui Tsou, Yung-An Tyler, Matthew Wu, Chien-Ting Yan, Carol Yeh, Te-Huei Zarabanda, David
Source	MedRxiv; Medline; PMC
abstract	We investigated the expression and subcellular localization of the SARS-CoV-2 receptor, angiotensin-converting enzyme 2 (ACE2), within the upper (nasal) and lower (pulmonary) respiratory tracts of healthy human donors. We detected ACE2 protein expression within the cilia organelle of ciliated airway epithelial cells, which likely represents the initial or early subcellular site of SARS-CoV-2 viral entry during respiratory transmission. We further determined whether ACE2 expression in the cilia of upper respiratory cells was influenced by patient demographics, clinical characteristics, co-morbidities, or medication use, and found no evidence that the use of angiotensin-converting enzyme inhibitors (ACEI) or angiotensin II receptor blockers (ARBs) increases ACE2 protein expression.
has issue date	2020-05-12(xsd:dateTime)
bibo:doi	10.1101/2020.05.08.20092866
bibo:pmid	32511516
has license	no-cc
sha1sum (hex)	162e76f892c3087db63de74bc8be74fecfc7eeab
schema:url	https://doi.org/10.1101/2020.05.08.20092866
resource representing a document's title	Robust ACE2 protein expression localizes to the motile cilia of the respiratory tract epithelia and is not increased by ACE inhibitors or angiotensin receptor blockers
has PubMed Central identifier	PMC7273284
has PubMed identifier	32511516
schema:publication	medRxiv
resource representing a document's body	covid:162e76f892c3087db63de74bc8be74fecfc7eeab#body_text
is schema:about of	named entity 'pulmonary' named entity 'ACE2' named entity 'respiratory' named entity 'expression' named entity 'expression' named entity 'localizes' named entity 'epithelia' covid:arg/162e76f892c3087db63de74bc8be74fecfc7eeab named entity 'SARS-CoV-2' named entity 'respiratory' named entity 'influenced' named entity 'detected' named entity 'ciliated' named entity 'clinical characteristics' named entity 'upper respiratory' named entity 'SARS-CoV-2' named entity 'ACE2' named entity 'cilia' named entity 'protein expression' named entity 'ACE inhibitors' named entity 'ACE2' named entity 'protein' named entity 'ACE2' named entity 'respiratory' named entity 'medRxiv' named entity 'Coronavirus disease 2019' named entity 'oral mucosa' named entity 'protein expression' named entity 'primary cilia' named entity 'organelle' named entity 'ACE2' named entity 'antibodies' named entity 'staining' named entity 'COVID' named entity 'SARS-CoV-2' named entity 'ARBs' named entity 'peer review' named entity 'Tissue sections' named entity 'motile cilia' named entity 'TMPRSS2' named entity 'multiple comparison' named entity 'SARS-CoV-2' named entity 'Abcam' named entity 'epithelial cell' named entity 'respiratory tracts' named entity 'DMEM'

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