About: Apolipoprotein M Gene (APOM) Polymorphism Modifies Metabolic and Disease Traits in Type 2 Diabetes

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Apolipoprotein M Gene (APOM) Polymorphism Modifies Metabolic and Disease Traits in Type 2 Diabetes Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Apolipoprotein M Gene (APOM) Polymorphism Modifies Metabolic and Disease Traits in Type 2 Diabetes
Creator	Geng, H Li, S-K Ng, Mcy Tsui, Skw Zhou, J-W
Source	PMC
abstract	This study aimed at substantiating the associations of the apolipoproein M gene (APOM) with type 2 diabetes (T2D) as well as with metabolic traits in Hong Kong Chinese. In addition, APOM gene function was further characterized to elucidate its activity in cholesterol metabolism. Seventeen APOM SNPs documented in the NCBI database were genotyped. Five SNPs were confirmed in our study cohort of 1234 T2D and 606 control participants. Three of the five SNPs rs707921(C+1871A), rs707922(G+1837T) and rs805264(G+203A) were in linkage disequilibrium (LD). We chose rs707922 to tag this LD region for down stream association analyses and characterized the function of this SNP at molecular level. No association between APOM and T2D susceptibility was detected in our Hong Kong Chinese cohort. Interestingly, the C allele of rs805297 was significantly associated with T2D duration of longer than 10 years (OR = 1.245, p = 0.015). The rs707922 TT genotype was significantly associated with elevated plasma total- and LDL- cholesterol levels (p = 0.006 and p = 0.009, respectively) in T2D patients. Molecular analyses of rs707922 lead to the discoveries of a novel transcript APOM5 as well as the cryptic nature of exon 5 of the gene. Ectopic expression of APOM5 transcript confirmed rs707922 allele-dependent activity of the transcript in modifying cholesterol homeostasis in vitro. In conclusion, the results here did not support APOM as a T2D susceptibility gene in Hong Kong Chinese. However, in T2D patients, a subset of APOM SNPs was associated with disease duration and metabolic traits. Further molecular analysis proved the functional activity of rs707922 in APOM expression and in regulation of cellular cholesterol content.
has issue date	2011-02-24(xsd:dateTime)
bibo:doi	10.1371/journal.pone.0017324
bibo:pmid	21390319
has license	cc-by
sha1sum (hex)	164f0fed97b05b34ea5df0f4e4e9e204d05f7849
schema:url	https://doi.org/10.1371/journal.pone.0017324
resource representing a document's title	Apolipoprotein M Gene (APOM) Polymorphism Modifies Metabolic and Disease Traits in Type 2 Diabetes
has PubMed Central identifier	PMC3044746
has PubMed identifier	21390319
schema:publication	PLoS One
resource representing a document's body	covid:164f0fed97b05b34ea5df0f4e4e9e204d05f7849#body_text
is schema:about of	named entity 'Ectopic expression' named entity 'tag' named entity 'Hong Kong' named entity 'metabolic' named entity 'SNP' named entity 'T2D' covid:arg/164f0fed97b05b34ea5df0f4e4e9e204d05f7849 named entity 'homeostasis' named entity 'content' named entity 'traits' named entity '10 years' named entity 'cohort' named entity 'SNPs' named entity 'T2D' named entity 'confirmed' named entity 'metabolic' named entity 'disease' named entity 'Disease' named entity 'molecular analysis' named entity 'APOM' named entity 'Hong Kong' named entity 'APOM' named entity 'genotyped' named entity 'cholesterol metabolism' named entity 'T2D' named entity 'T2D' named entity 'Ectopic expression' named entity 'association analyses' named entity 'type 2 diabetes' named entity 'functional activity' named entity 'molecular level' named entity 'control participants' named entity 'cryptic nature' named entity 'T2D' named entity 'SNPs' named entity 'homeostasis' named entity 'exon' named entity 'gene' named entity 'cholesterol' named entity 'APOM' named entity 'allele' named entity 'T2D' named entity 'LDL-cholesterol' named entity 'SNPs' named entity 'APOM' named entity 'expression' named entity 'Rockville, MD' named entity 'metabolic' named entity 'Applied Biosystems' named entity '95% confidence interval' named entity 'risk factor' named entity 'DNA samples' named entity 'T2D' named entity 'insulin' named entity 'Invitrogen' named entity 'cDNA' named entity 'metabolic' named entity 'expression levels' named entity 'data quality' named entity 'APOM' named entity 'kidney' named entity 'cholesterol' named entity 'lipid' named entity 'APOM' named entity 'regression analysis' named entity 'allele' named entity 'genotyped' named entity 'SNP' named entity 'APOM' named entity 'cholesterol' named entity 'diabetes' named entity 'cholesterol' named entity 'apoM' named entity 'reverse cholesterol transport' named entity 'Comparative genomic' named entity 'gene' named entity 'SNPs'

Faceted Search & Find service v1.13.91 as of Mar 24 2020

Alternative Linked Data Documents: Sponger | ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3229 as of Jul 10 2020, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (94 GB total memory)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software