About: Core Outcome Set for Clinical Trials on Coronavirus Disease 2019 (COS-COVID)

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Core Outcome Set for Clinical Trials on Coronavirus Disease 2019 (COS-COVID) Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Core Outcome Set for Clinical Trials on Coronavirus Disease 2019 (COS-COVID)
Creator	Sun, Yu Zhu, Yan Zhao, Min Zhang, Lei Du, Liang Liu, Qingquan Zhang, Junhua Zhang, Shuo Li, Youping Lee, Soo Huang, Ming Chua, Huizi Fauci, Alice Feng, Jihong Gao, Rui Hu, Jingqing Huang, Yuhong Jin, Xinyao Liu, Xuezheng Ma, Yuling Ou, Yi Pang, Bo Qi, Hanmei Tang, Jianyuan Tian, Jinhui Wang, Baohe Wang, Keyi Wei'an Yuan, Xie, Yanming Yang, Fengwen Yang, Zhongqi Yao, Chen Yu, Jiajie Zhang, Boli Zheng, Wenke
source	Elsevier; Medline; PMC
abstract	Abstract Since its outbreak in December 2019, a series of clinical trials on Coronavirus Disease 2019 (COVID-19) have been registered or carried out. However, the significant heterogeneity and less critical outcomes of such trials may be leading to a waste of research resources. This study aimed to develop a core outcome set (COS) for clinical trials on COVID-19 in order to tackle the outcome issues. The study was conducted according to the Core Outcome Measures in Effectiveness Trials (COMET) handbook (version 1.0), a guideline for COS development. A research group was set up that included experts in respiratory and critical medicine, traditional Chinese medicine, evidence-based medicine, clinical pharmacology, and statistics, in addition to medical journal editors. Clinical trial registry websites (chictr.org.cn and clinicaltrials.gov) were searched to retrieve clinical trial protocols and outcomes in order to form an outcome pool. A total of 78 clinical trial protocols on COVID-19 were included and 259 outcomes were collected. After standardization, 132 outcomes were identified within seven different categories, of which 58 were selected to develop a preliminary outcome list for further consensus. After two rounds of Delphi survey and one consensus meeting, the most important outcomes for the different clinical classifications of COVID-19 were identified and determined to constitute the COS for clinical trials on COVID-19 (COS-COVID). The COS-COVID includes one outcome for the mild type (time to 2019-nCoV reverse transcription-polymerase chain reaction (RT-PCR) negativity), four outcomes for the ordinary type (length of hospital stay, composite events, score of clinical symptoms, and time to 2019-nCoV RT-PCR negativity), five outcomes for the severe type (composite events, length of hospital stay, arterial oxygen partial pressure (PaO2)/fraction of inspired oxygen (FiO2), duration of mechanical ventilation, and time to 2019-nCoV RT-PCR negativity), one outcome for critical type (all-cause mortality), and one outcome for rehabilitation period (pulmonary function). The COS-COVID is currently the most valuable and practical clinical outcome set for the evaluation of intervention effect, and is useful for evidence assessment and decision-making. With a deepening understanding of COVID-19 and application feedback, the COS-COVID should be continuously updated.
has issue date	2020-03-18(xsd:dateTime)
bibo:doi	10.1016/j.eng.2020.03.002
bibo:pmid	32292626
has license	els-covid
sha1sum (hex)	165562ba942e0a8aa506fdf31fd8ade1a7e0ef1e
schema:url	https://doi.org/10.1016/j.eng.2020.03.002
resource representing a document's title	Core Outcome Set for Clinical Trials on Coronavirus Disease 2019 (COS-COVID)
has PubMed Central identifier	PMC7102592
has PubMed identifier	32292626
schema:publication	Engineering (Beijing)
resource representing a document's body	covid:165562ba942e0a8aa506fdf31fd8ade1a7e0ef1e#body_text
is schema:about of	named entity 'statistics' named entity 'set' named entity 'COS' named entity 'clinicaltrials.gov' named entity 'COS' named entity 'develop' named entity 'RT-PCR' named entity 'Trials' named entity 'COMET' named entity 'standardization' named entity 'conducted' named entity 'identified' named entity 'experts' named entity 'traditional Chinese medicine' named entity 'mild' named entity 'selected' named entity 'chain reaction' named entity 'length' named entity 'Disease' named entity 'protocols' named entity 'Core' named entity 'Coronavirus Disease 2019' named entity 'Delphi' named entity 'clinical trial' named entity 'COVID' named entity 'clinical pharmacology' named entity 'clinical trial' named entity 'Clinical Trials' named entity 'time' named entity 'COVID' named entity 'intensive care unit' named entity 'infectious diseases' named entity 'reverse transcription-polymerase chain reaction' named entity 'coronavirus disease 2019' named entity 'magnetic resonance imaging' named entity 'clinical trial registries' named entity 'data analysis' named entity 'physiology' named entity 'CBC' named entity 'acute respiratory distress syndrome' named entity 'Delphi' named entity 'Sichuan' named entity 'blood pressure' named entity 'chest CT' named entity 'cohort studies' named entity 'United Kingdom' named entity 'clinical study'

Faceted Search & Find service v1.13.91 as of Mar 24 2020

Alternative Linked Data Documents: Sponger | ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3229 as of Jul 10 2020, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (94 GB total memory)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2025 OpenLink Software