About: Ultrasound in managing extrapulmonary tuberculosis: a randomized controlled two-center study

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Ultrasound in managing extrapulmonary tuberculosis: a randomized controlled two-center study
Creator	Battegay, Manuel Bani, Farida Gingo, Winfrid Hella, Jerry Hiza, Helen Kato, Irene Kimera, Namvua Mapesi, Herry Mhimbira, Francis Mnzava, Dorcas Ndege, Robert Ngome, Omary Paris, Daniel Reither, Klaus Rohacek, Martin Sasamalo, Mohamed Temba, Yvan Vanobberghen, Fiona Weisser, Maja Wigayi, John Wilson, Herieth
Source	Medline; PMC
abstract	BACKGROUND: Patients with clinically suspected tuberculosis are often treated empirically, as diagnosis - especially of extrapulmonary tuberculosis - remains challenging. This leads to an overtreatment of tuberculosis and to underdiagnosis of possible differential diagnoses. METHODS: This open-label, parallel-group, superiority randomized controlled trial is done in a rural and an urban center in Tanzania. HIV-positive and -negative adults (≥18 years) with clinically suspected extrapulmonary tuberculosis are randomized in a 1:1 ratio to an intervention- or control group, stratified by center and HIV status. The intervention consists of a management algorithm including extended focused assessment of sonography for HIV and tuberculosis (eFASH) in combination with chest X-ray and microbiological tests. Treatment with anti-tuberculosis drugs is started, if eFASH is positive, chest X-ray suggests tuberculosis, or a microbiological result is positive for tuberculosis. Patients in the control group are managed according national guidelines. Treatment is started if microbiology is positive or empirically according to the treating physician. The primary outcome is the proportion of correctly managed patients at 6 months (i.e patients who were treated with anti-tuberculosis treatment and had definite or probable tuberculosis, and patients who were not treated with anti-tuberculosis treatment and did not have tuberculosis). Secondary outcomes are the proportion of symptom-free patients at two and 6 months, and time to death. The sample size is 650 patients. DISCUSSION: This study will determine, whether ultrasound in combination with other tests can increase the proportion of correctly managed patients with clinically suspected extrapulmonary tuberculosis, thus reducing overtreatment with anti-tuberculosis drugs. TRIAL REGISTRATION: PACTR, Registration number: PACTR201712002829221, registered December 1st 2017.
has issue date	2020-05-15(xsd:dateTime)
bibo:doi	10.1186/s12879-020-05073-9
bibo:pmid	32414338
has license	cc-by
sha1sum (hex)	1655b77b80ff2377ac59aef5de0137f006d55a52
schema:url	https://doi.org/10.1186/s12879-020-05073-9
resource representing a document's title	Ultrasound in managing extrapulmonary tuberculosis: a randomized controlled two-center study
has PubMed Central identifier	PMC7226714
has PubMed identifier	32414338
schema:publication	BMC Infect Dis
resource representing a document's body	covid:1655b77b80ff2377ac59aef5de0137f006d55a52#body_text
is schema:about of	named entity 'SUSPECTED' named entity 'tuberculosis' named entity 'intestinal obstruction' named entity 'tuberculosis' named entity 'axillary lymphadenopathy' named entity 'fine needle aspiration' named entity 'people living with HIV' named entity 'sputum' named entity 'HIV status' named entity 'control group' named entity 'ultrasound' named entity 'positive or negative' named entity 'Pleural' named entity 'extrapulmonary tuberculosis' named entity 'Tanzania' named entity 'sample size' named entity 'Mwananyamala' named entity 'Interrater reliability' named entity 'liver cirrhosis' named entity 'Ultrasound' named entity 'tuberculosis' named entity 'pleural' named entity 'extrapulmonary tuberculosis' named entity 'cerebrospinal fluid' named entity 'sputum' named entity 'Microbiological' named entity 'chest X-ray' named entity 'adenosine deaminase' named entity 'heart failure' named entity 'nuchal' named entity 'tuberculosis' named entity 'subpleural' named entity 'ascites' named entity 'Xpert MTB/RIF' named entity 'ascites' named entity 'clinical evaluation' named entity 'Microbiological' named entity 'Xpert MTB/RIF' named entity 'chest X-ray' named entity 'tuberculosis' named entity 'tuberculosis' named entity 'tuberculosis' named entity 'blood pressure' named entity 'heart failure' named entity 'physical examination' named entity 'ultrasound' named entity 'Dar es salaam' named entity 'Poway' named entity 'co-infected' named entity 'tuberculosis' named entity 'tuberculosis treatment' named entity 'ultrasound' named entity 'tuberculosis' named entity 'urine samples' named entity 'sample size' named entity 'heart failure' named entity 'false positive results' named entity 'extrapulmonary tuberculosis' named entity 'sonography' named entity 'Löwenstein-Jensen' named entity '10 million'

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