About: Display of Porcine Epidemic Diarrhea Virus Spike Protein on Baculovirus to Improve Immunogenicity and Protective Efficacy

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About: Display of Porcine Epidemic Diarrhea Virus Spike Protein on Baculovirus to Improve Immunogenicity and Protective Efficacy Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Display of Porcine Epidemic Diarrhea Virus Spike Protein on Baculovirus to Improve Immunogenicity and Protective Efficacy
Creator	Chang, Hui-Wen Chang, Chia-Yu Chao, Yu-Chan Hsu, Wei-Ting Id, ‡
Source	Medline; PMC
abstract	A new variant of the porcine epidemic diarrhea virus (PEDV) is an emerging swine disease, killing considerable numbers of neonatal piglets in North America and Asia in recent years. To generate immunogens mimicking the complex spike (S) protein folding with proper posttranslational modification to mount a robust immune response against the highly virulent PEDV, two baculoviruses displaying the full-length S protein (S-Bac) and the S1 protein (S1-Bac) of the virulent Taiwan genotype 2b (G2b) PEDV Pintung 52 (PEDV-PT) strain were constructed. Intramuscular immunizations of mice and piglets with the S-Bac and S1-Bac demonstrated significantly higher levels of systemic anti-PEDV S-specific IgG, as compared with control group. Our results also showed that piglets in the S-Bac group elicited superior PEDV-specific neutralizing antibodies than those of the S1-Bac and control groups. The highly virulent PEDV-PT strain challenge experiment showed that piglets immunized with S-Bac and S1-Bac showed milder clinical symptoms with significantly less fecal viral shedding as compared with non-immunized control piglets. More importantly, piglets immunized with the S-Bac exhibited no to mild clinical signs, with a delayed, minimal viral shedding. Our results demonstrated that the S-Bac could serve as a safe, easy to manipulate, and effective vaccine candidate against the PEDV infection.
has issue date	2018-06-27(xsd:dateTime)
bibo:doi	10.3390/v10070346
bibo:pmid	29954081
has license	cc-by
sha1sum (hex)	1673be3a6c0cd5762dcdabc21816f4acdc102e31
schema:url	https://doi.org/10.3390/v10070346
resource representing a document's title	Display of Porcine Epidemic Diarrhea Virus Spike Protein on Baculovirus to Improve Immunogenicity and Protective Efficacy
has PubMed Central identifier	PMC6071207
has PubMed identifier	29954081
schema:publication	Viruses
resource representing a document's body	covid:1673be3a6c0cd5762dcdabc21816f4acdc102e31#body_text
is schema:about of	named entity 'control' named entity 'Bac' named entity 'virulent' named entity 'viral shedding' named entity 'G2b' named entity 'mimicking' named entity 'vaccine' named entity 'highly' named entity 'Baculovirus' covid:arg/1673be3a6c0cd5762dcdabc21816f4acdc102e31 named entity 'highly' named entity 'Taiwan' named entity 'minimal' named entity 'complex' named entity 'mild' named entity 'robust' named entity 'virulent' named entity 'killing' named entity 'control group' named entity 'neutralizing antibodies' named entity 'clinical signs' named entity 'Asia' named entity 'control group' named entity 'immunizations' named entity 'vaccine' named entity 'PEDV' named entity 'viral shedding' named entity 'spike (S) protein' named entity 'G2b' named entity 'control groups' named entity 'Immunogenicity' named entity 'Porcine Epidemic Diarrhea Virus' named entity 'detection limit' named entity 'swine' named entity 'mice' named entity 'IgG' named entity 'viral shedding' named entity 'cholera toxin' named entity 'baculovirus' named entity 'control group' named entity 'vaccine' named entity 'Wild type' named entity 'viruses' named entity 'Dulbecco's modified Eagle's medium' named entity 'Chatsworth, CA' named entity 'virus' named entity 'wild type' named entity 'Wild-type' named entity 'kDa' named entity 'plasmids' named entity 'intramuscularly' named entity 'viral shedding' named entity 'immunizations' named entity 'gene product' named entity 'control group' named entity 'wild-type' named entity 'PEDV' named entity 'virions' named entity 'PEDV' named entity 'baculovirus' named entity 'recombinant' named entity 'PEDV' named entity 'viral particle' named entity 'fluorescent' named entity 'mucosal immunity' named entity 'real-time PCR' named entity 'significant difference' named entity 'recombinant' named entity 'control group' named entity 'protein' named entity 'plasma' named entity 'antigens' named entity 'IgA' named entity 'IgG' named entity 'TCID50' named entity 'PEDV' named entity 'optical density'

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