About: Identification of RNase L-Dependent, 3′-End-Modified, Viral Small RNAs in Sindbis Virus-Infected Mammalian Cells

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About: Identification of RNase L-Dependent, 3′-End-Modified, Viral Small RNAs in Sindbis Virus-Infected Mammalian Cells Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Identification of RNase L-Dependent, 3′-End-Modified, Viral Small RNAs in Sindbis Virus-Infected Mammalian Cells
Creator	Chane-Woon-Ming, Béatrice Girardi, Erika Kaukinen, Pasi Messmer, Mélanie Pfeffer, Sébastien
Source	PMC
abstract	Small RNAs play a critical role in host-pathogen interaction. Indeed, small RNA-mediated silencing or RNA interference (RNAi) is one of the earliest forms of antiviral immunity. Although it represents the main defense system against viruses in many organisms, the antiviral role of RNAi has not been clearly proven in higher vertebrates. However, it is well established that their response to viral infection relies on the recognition of viral RNAs by host pattern recognition receptors (PRRs) to trigger activation of the interferon pathway. In the present work, we report the existence of a novel small noncoding RNA population produced in mammalian cells upon RNA virus infection. Using Sindbis virus (SINV) as a prototypic arbovirus model, we profiled the small RNA population of infected cells in both human and African green monkey cell lines. Here, we provide evidence for the presence of discrete small RNAs of viral origin that are not associated with the RNA-induced silencing complex (RISC), that are highly expressed and detected by Northern blot analysis, and that accumulate as 21- to 28-nucleotide (nt) species during infection. We report that the cellular antiviral endoribonuclease RNase L cleaves the viral genome, producing in turn the small RNAs. Surprisingly, we uncovered the presence of a modification on the 3′-end nucleotide of SINV-derived viral small RNAs (SvsRNAs) that might be at the origin of their stability. Altogether, our findings show that stable modified small viral RNAs could represent a novel way to modulate host-virus interaction upon SINV infection.
has issue date	2013-11-19(xsd:dateTime)
bibo:doi	10.1128/mbio.00698-13
bibo:pmid	24255120
has license	cc-by-nc-sa
sha1sum (hex)	1685a03eac1fe5f949aa6b7889e02dadf9d3f90f
schema:url	https://doi.org/10.1128/mbio.00698-13
resource representing a document's title	Identification of RNase L-Dependent, 3′-End-Modified, Viral Small RNAs in Sindbis Virus-Infected Mammalian Cells
has PubMed Central identifier	PMC3870239
has PubMed identifier	24255120
schema:publication	mBio
resource representing a document's body	covid:1685a03eac1fe5f949aa6b7889e02dadf9d3f90f#body_text
is schema:about of	named entity 'immunity' named entity 'host-pathogen interaction' named entity 'accumulate' named entity 'viral' named entity 'RNAi' named entity 'presence' named entity 'Cells' named entity 'CELLS' named entity 'RNAS' named entity 'MODIFIED' named entity 'RNAS' named entity 'STABILITY' named entity 'MODIFIED' named entity 'RNA VIRUS' named entity 'ACTIVATION' named entity 'PATHWAY' named entity 'EVIDENCE FOR' named entity 'HOST-PATHOGEN INTERACTION' named entity 'AFRICAN GREEN MONKEY' named entity 'WORK' named entity 'DEFENSE' named entity 'INFECTION' named entity 'SMALL RNA' named entity 'VIRAL GENOME' named entity 'HOST' named entity 'ROLE' named entity 'RNAI' named entity 'VIRAL INFECTION' named entity 'MODIFICATION' named entity 'FINDINGS' named entity 'RNASE L' named entity 'ONE OF' named entity 'TRIGGER' named entity 'FORMS' named entity 'NORTHERN BLOT ANALYSIS' named entity 'MODEL' named entity 'PATTERN RECOGNITION RECEPTORS' named entity 'THEIR' named entity 'MAMMALIAN' named entity 'INFECTED' named entity 'DEPENDENT' named entity 'SINDBIS VIRUS' named entity 'SMALL' named entity 'END' named entity 'RNASE L' named entity 'VIRAL' named entity 'ASSOCIATED WITH' named entity 'RNA-INDUCED SILENCING COMPLEX' named entity 'ORGANISMS' named entity 'MAIN' named entity 'VERTEBRATES' named entity 'CELL LINES' named entity 'PRESENT' named entity 'NUCLEOTIDE' named entity 'HUMAN' named entity 'ORIGIN' named entity 'ANTIVIRAL' named entity 'ESTABLISHED' named entity 'ARBOVIRUS' named entity 'DETECTED' named entity 'MODULATE' named entity 'OUR' named entity 'SMALL' named entity 'CRITICAL' named entity 'END' named entity 'TURN' named entity 'RNA INTERFERENCE' named entity 'VIRUSES' named entity 'HIGHER' named entity 'HOST-VIRUS INTERACTION' named entity 'PRODUCING' named entity 'IMMUNITY' named entity 'USING' named entity 'MIGHT BE' named entity 'CELLS' named entity 'VIRAL' named entity 'NOVEL'

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