About: An NTP-binding motif is the most conserved sequence in a highly diverged monophyletic group of proteins involved in positive strand RNA viral replication

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About: An NTP-binding motif is the most conserved sequence in a highly diverged monophyletic group of proteins involved in positive strand RNA viral replication Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	An NTP-binding motif is the most conserved sequence in a highly diverged monophyletic group of proteins involved in positive strand RNA viral replication
Creator	Gorbalenya, Alexander Blinov, Vladimir Donchenko, Alexei Koonin, Eugene
topic	covid:168742a4bd4399a662dfed951baa54b216b14711#this
Source	Medline; PMC
abstract	NTP-motif, a consensus sequence previously shown to be characteristic of numerous NTP-utilizing enzymes, was identified in nonstructural proteins of several groups of positive-strand RNA viruses. These groups include picorna-, alpha-, and coronaviruses infecting animals and como-, poty-, tobamo-, tricorna-, hordei-, and furoviruses of plants, totalling 21 viruses. It has been demonstrated that the viral NTP-motif-containing proteins constitute three distinct families, the sequences within each family being similar to each other at a statistically highly significant level. A lower, but still valid similarity has also been revealed between the families. An overall alignment has been generated, which includes several highly conserved sequence stretches. The two most prominent of the latter contain the socalled “A” and “B” sites of the NTP-motif, with four of the five invariant amino acid residues observed within these sequences. These observations, taken together with the results of comparative analysis of the positions occupied by respective proteins (domains) in viral multidomain proteins, suggest that all the NTP-motif-containing proteins of positive-strand RNA viruses are homologous, constituting a highly diverged monophyletic group. In this group the “A” and “B” sites of the NTP-motif are the most conserved sequences and, by inference, should play the principal role in the functioning of the proteins. A hypothesis is proposed that all these proteins posses NTP-binding capacity and possibly NTPase activity, performing some NTP-dependent function in viral RNA replication. The importance of phylogenetic analysis for the assessment of the significance of the occurrence of the NTP-motif (and of sequence motifs of this sort in general) in proteins is emphasized.
has issue date	1989-01-01(xsd:dateTime)
bibo:doi	10.1007/bf02102483
bibo:pmid	2522556
has license	no-cc
sha1sum (hex)	168742a4bd4399a662dfed951baa54b216b14711
schema:url	https://doi.org/10.1007/bf02102483
resource representing a document's title	An NTP-binding motif is the most conserved sequence in a highly diverged monophyletic group of proteins involved in positive strand RNA viral replication
has PubMed Central identifier	PMC7087505
has PubMed identifier	2522556
schema:publication	J Mol Evol
resource representing a document's body	covid:168742a4bd4399a662dfed951baa54b216b14711#body_text
is http://vocab.deri.ie/void#inDataset of	proxy:http/ns.inria.fr/covid19/168742a4bd4399a662dfed951baa54b216b14711
is schema:about of	named entity 'PROTEINS' named entity 'MONOPHYLETIC' named entity 'POSITIVE STRAND' named entity 'RNA VIRUSES' named entity 'POSITIONS' named entity '22A' named entity 'ALPHA' named entity 'VIRUSES' named entity 'NTP' named entity 'FUNCTION' named entity 'REVEALED' named entity 'SORT' named entity 'OBSERVED' named entity 'VALID' named entity 'CHARACTERISTIC' named entity 'SIGNIFICANCE' named entity 'RESULTS' named entity 'OBSERVATIONS' named entity 'BEING' named entity 'NTPASE ACTIVITY' named entity 'CONTAIN' named entity 'POSSESS' named entity 'STRAND' named entity 'BUT' named entity 'JOURNAL ' named entity 'MOLECULAR EVOLUTION' named entity 'HIGHLY SIGNIFICANT' named entity 'PROTEINS' named entity 'GROUP' named entity 'SEQUENCE MOTIFS' named entity 'MOTIF' named entity 'CONSERVED SEQUENCE' named entity 'INVOLVED' named entity 'NTP' named entity 'ROLE' named entity 'DEPENDENT' named entity 'GENERAL' named entity 'BINDING' named entity 'HIGHLY' named entity 'RNA' named entity 'GROUP' named entity 'STATISTICALLY' named entity 'VIRAL' named entity 'STRETCHES' named entity 'DISTINCT' named entity 'INCLUDES' named entity 'CONSENSUS SEQUENCE' named entity 'SUGGEST' named entity 'POSITIVE' named entity 'MONOPHYLETIC' named entity 'PREVIOUSLY' named entity 'BINDING CAPACITY' named entity 'OCCURRENCE' named entity 'HIGHLY' named entity 'SIMILARITY' named entity 'NONSTRUCTURAL PROTEINS' named entity 'PROPOSED' named entity 'HOMOLOGOUS' named entity 'LEVEL' named entity 'TAKEN' named entity 'FAMILIES' named entity 'REQUESTS' named entity 'SITES' named entity 'VIRAL RNA' named entity 'IDENTIFIED' named entity 'OVERALL' named entity 'MOTIF' named entity 'LOWER' named entity 'ALIGNMENT' named entity 'FAMILY' named entity 'PLANTS' named entity 'CONSERVED' named entity 'PROMINENT' named entity 'PRINCIPAL' named entity 'SEQUENCES' named entity 'THESE'

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