About: Discovery of the Proprotein Convertases and their Inhibitors

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Discovery of the Proprotein Convertases and their Inhibitors
Creator	Seidah, Nabil
Source	PMC
abstract	The members of the convertase family play a central role in the processing of various protein precursors ranging from hormones and growth factors to viral envelope proteins and bacterial toxins. The proteolysis of these precursors that occurs at basic residues is mediated by the proprotein convertases (PCs), namely: PC1, PC2, Furin, PACE4, PC4, PC5 and PC7. The proteolysis at non-basic residues is performed by subtilisin/kexin-like isozyme-1 (S1P/SKI-1) and the newly identified neural apoptosis-regulated convertase-1 (NARC-1/PCSK9). These proteases have key roles in many physiological processes and various pathologies including cancer, obesity, diabetes, neurodegenerative diseases and autosomal dominant hypercholesterolermia. Here we summarize the discovery of the proprotein convertases and their inhibitors, discuss their properties, roles, resemblance and differences
has issue date	2006-01-01(xsd:dateTime)
bibo:doi	10.1007/1-4020-5132-8_1
has license	no-cc
sha1sum (hex)	168c4d60111914d88ca70454eb0194c43a8e23b9
schema:url	https://doi.org/10.1007/1-4020-5132-8_1
resource representing a document's title	Discovery of the Proprotein Convertases and their Inhibitors
has PubMed Central identifier	PMC7122317
schema:publication	Regulation of Carcinogenesis, Angiogenesis and Metastasis by the Proprotein Convertases (PCs)
resource representing a document's body	covid:168c4d60111914d88ca70454eb0194c43a8e23b9#body_text
is schema:about of	named entity 'BEDSIDE' named entity 'PROPROTEIN CONVERTASES' named entity 'furin' named entity 'von Willebrand factor' named entity 'Lys' named entity 'subnanomolar' named entity 'catalytic domain' named entity 'cytosol' named entity 'vesicles' named entity 'oligonucleotide' named entity 'subtilisin' named entity 'non-sense mutations' named entity 'growth factors' named entity 'transcription of target genes' named entity 'protooncogene' named entity 'propeptide' named entity 'PC4' named entity 'cytoplasmic' named entity 'proteinase' named entity 'gp160' named entity 'upregulate' named entity 'cleavage' named entity 'substrates' named entity 'SREBPs' named entity 'substrates' named entity 'proteinase inhibitor' named entity 'proteolysis' named entity 'autocatalytically' named entity 'kexin' named entity 'N-terminal' named entity 'protein' named entity 'Furin' named entity 'Furin' named entity 'naturally occurring' named entity 'secretion' named entity 'signal peptide' named entity 'cleavage' named entity 'Homology' named entity 'gene' named entity 'Golgi' named entity 'serine proteinases' named entity 'sterol regulatory element binding proteins' named entity 'mRNA' named entity 'spermatids' named entity 'Mice' named entity 'SREs' named entity 'apoptosis' named entity 'amino acid' named entity 'chloromethane' named entity 'open reading frame' named entity 'feedback mechanism' named entity 'homology' named entity 'primers' named entity 'phenotype' named entity 'catalytic region' named entity 'PACE4' named entity 'Northern blot analyses' named entity 'PC4' named entity 'circulating cholesterol' named entity 'dibasic' named entity 'cytokines' named entity 'PACE4' named entity 'PC2' named entity 'enzyme' named entity 'C-terminal' named entity 'PCSK9' named entity 'protein' named entity 'luminal' named entity 'naturally occurring' named entity 'IGH' named entity 'glycoproteins' named entity 'tumor growth' named entity 'cDNA' named entity 'C-terminal' named entity 'exogenous' named entity 'cleavage' named entity 'mRNA expression' named entity 'platelet' named entity 'proteolytic' named entity 'amino acid residues' named entity 'protein' named entity 'human chromosome 20' named entity 'substrates'

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