About: Gene expression analysis reveals schizophrenia-associated dysregulation of immune pathways in peripheral blood mononuclear cells

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Gene expression analysis reveals schizophrenia-associated dysregulation of immune pathways in peripheral blood mononuclear cells Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Gene expression analysis reveals schizophrenia-associated dysregulation of immune pathways in peripheral blood mononuclear cells
Creator	Carr, Vaughan Kelly, Brian Liu, Bing Beveridge, Natalie Cairns, Murray Gardiner, Erin Scott, Rodney Tooney, Paul
Source	Elsevier; Medline; PMC
abstract	Abstract Peripheral blood mononuclear cells (PBMCs) represent an accessible tissue source for gene expression profiling in schizophrenia that could provide insight into the molecular basis of the disorder. This study used the Illumina HT_12 microarray platform and quantitative real time PCR (QPCR) to perform mRNA expression profiling on 114 patients with schizophrenia or schizoaffective disorder and 80 non-psychiatric controls from the Australian Schizophrenia Research Bank (ASRB). Differential expression analysis revealed altered expression of 164 genes (59 up-regulated and 105 down-regulated) in the PBMCs from patients with schizophrenia compared to controls. Bioinformatic analysis indicated significant enrichment of differentially expressed genes known to be involved or associated with immune function and regulating the immune response. The differential expression of 6 genes, EIF2C2 (Ago 2), MEF2D, EVL, PI3, S100A12 and DEFA4 was confirmed by QPCR. Genome-wide expression analysis of PBMCs from individuals with schizophrenia was characterized by the alteration of genes with immune system function, supporting the hypothesis that the disorder has a significant immunological component in its etiology.
has issue date	2013-04-30(xsd:dateTime)
bibo:doi	10.1016/j.jpsychires.2012.11.007
bibo:pmid	23218666
has license	els-covid
sha1sum (hex)	16a4b3acbf0f8aeecd2156786377cbe85bd648aa
schema:url	https://doi.org/10.1016/j.jpsychires.2012.11.007
resource representing a document's title	Gene expression analysis reveals schizophrenia-associated dysregulation of immune pathways in peripheral blood mononuclear cells
has PubMed Central identifier	PMC7094548
has PubMed identifier	23218666
schema:publication	Journal of Psychiatric Research
resource representing a document's body	covid:16a4b3acbf0f8aeecd2156786377cbe85bd648aa#body_text
is schema:about of	named entity 'SCHIZOPHRENIA' named entity 'Peripheral' named entity 'represent' named entity 'etiology' named entity 'schizophrenia' named entity 'mononuclear cells' named entity 'REVEALS' named entity 'EVL' named entity 'SOURCE' named entity 'INDICATED' named entity 'ALTERED' named entity 'DEFA4' named entity 'USED' named entity 'PBMCS' named entity 'EXPRESSION PROFILING' named entity 'HYPOTHESIS' named entity 'AUSTRALIAN' named entity 'DISORDER' named entity 'ACCESSIBLE' named entity 'SYSTEM FUNCTION' named entity 'PERIPHERAL BLOOD MONONUCLEAR CELLS' named entity 'NON-' named entity 'SCHIZOPHRENIA' named entity 'DIFFERENTIAL EXPRESSION' named entity 'MEF2D' named entity 'COMPONENT' named entity 'UP-REGULATED' named entity 'KNOWN' named entity 'SCHIZOAFFECTIVE DISORDER' named entity 'INSIGHT' named entity 'REGULATING' named entity 'REPRESENT' covid:arg/16a4b3acbf0f8aeecd2156786377cbe85bd648aa named entity 'ASSOCIATED' named entity 'PSYCHIATRIC' named entity 'ANALYSIS' named entity 'GENOME' named entity 'IMMUNE SYSTEM' named entity 'IMMUNOLOGICAL' named entity 'PERIPHERAL BLOOD MONONUCLEAR CELLS' named entity 'EXPRESSION ANALYSIS' named entity 'BIOINFORMATIC' named entity 'ENRICHMENT' named entity 'RESEARCH' named entity 'STUDY' named entity 'MRNA EXPRESSION' named entity 'TISSUE' named entity 'SIGNIFICANT' named entity 'MICROARRAY PLATFORM' named entity 'GENE EXPRESSION PROFILING' named entity 'S100A12' named entity 'IMMUNE FUNCTION' named entity 'PI3' named entity 'WIDE' named entity 'INVOLVED' named entity 'SUPPORTING' named entity '2859' named entity 'PATHWAYS' named entity 'IMMUNE' named entity 'DOWN-REGULATED' named entity 'EXPRESSED' named entity 'PATIENTS' named entity '114' named entity 'CHARACTERIZED' named entity 'IMMUNE RESPONSE' named entity 'EXPRESSION' named entity 'EIF2C2' named entity 'ETIOLOGY' named entity 'GENES' named entity 'PROVIDE' named entity 'INDIVIDUALS' named entity 'BANK' named entity 'ALTERATION' named entity 'ILLUMINA'

Faceted Search & Find service v1.13.91 as of Mar 24 2020

Alternative Linked Data Documents: Sponger | ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3229 as of Jul 10 2020, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (94 GB total memory)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software