About: A preliminary study on serological assay for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in 238 admitted hospital patients

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About: A preliminary study on serological assay for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in 238 admitted hospital patients Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	A preliminary study on serological assay for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in 238 admitted hospital patients
Creator	Liu, Lei Zhang, Yong Jiang, Hui Zhang, Bo Li, H Wang, S Tan, Li Wang, Qiongshu Jiang, H Zhang, X Jiang, X Hu, Zhenhong Ding, Jinya Ding, Y Hu, Z Huang, Q Huang, Qianchuan Liu, L Liu, W Ren, X Tang, Wang, Q Zhang, Y Zheng, Y Ding, Ding, Yinjuan Jiang, Xiaojing Kou, Guomei Li, Honghua Liu, Wanbing Ni, Wenxu Rao, Zhiguo Ren, Xingfeng Tang, Shi Wang, Shengdian Wu, Wanlei Xu, W Xu, Weitian Zhang, Xinhua Zheng, Shangen Zheng, Yaqiong Rao, Z Tang, S Zhang, B Wu, W Zheng, S Ding, J Kou, G Ni, W Tan, L Tang, Z Tang, Zhongzhi
source	Elsevier; Medline; PMC
abstract	In this study, we aimed to evaluate the diagnostic value of serological assay for SARS-CoV-2. A newly-developed ELISA assay for IgM and IgG antibodies against N protein of SARS-CoV-2 was used to screen the serums of 238 admitted hospital patients between February 6 and February 14, 2020 with confirmed or suspected SARS-CoV-2. SARS-CoV-2 RNA was detected on pharyngeal swab specimens using real time RT-PCR. 194 (81.5%) of the serums were detected to be antibody (IgM and/or IgG) positive, significantly higher than the positive rate of viral RNA (64.3%). There was no difference in the positive rate of antibodies between the confirmed patients (83.0%, 127/153) and the suspected patients (78.8%, 67/85), whose nucleic acid tests were negative. The antibody positive rates were very low in the first five days after initial onset of symptoms, and then rapidly increased as the disease progressed. After 10 days, the antibody positive rates jumped from below 50% to over 80%. However, the positive rates of viral RNA maintained above 60% in the first 11 days after initial onset of symptoms, and then rapidly decreased. Overall, the suspected patients were most likely infected by SARS-CoV-2. Before the 11th day after initial onset of symptoms, nucleic acid test is key for confirmation of viral infection. The combination of serological assay can greatly improve the diagnostic efficacy. After the 11th day post-disease onset, the diagnosis for viral infection should be majorly dependent on serological assay.
has issue date	2020-05-18(xsd:dateTime)
bibo:doi	10.1016/j.micinf.2020.05.008
bibo:pmid	32425648
has license	no-cc
sha1sum (hex)	16cbc30ba04eaeaed964386b1c0a85fad245f52f
schema:url	https://doi.org/10.1016/j.micinf.2020.05.008
resource representing a document's title	A preliminary study on serological assay for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in 238 admitted hospital patients
has PubMed Central identifier	PMC7233230
has PubMed identifier	32425648
schema:publication	Microbes Infect
resource representing a document's body	covid:16cbc30ba04eaeaed964386b1c0a85fad245f52f#body_text
is schema:about of	named entity 'Microbes' named entity 'serological' covid:arg/16cbc30ba04eaeaed964386b1c0a85fad245f52f named entity 'dependent' named entity 'The combination' named entity 'nucleic acid test' named entity 'serological' named entity 'efficacy' named entity 'patients' named entity 'hospital' named entity 'study' named entity 'onset' named entity 'confirmation' named entity 'assay' named entity 'patients' named entity 'viral infection' named entity 'Microbes' named entity 'SARS-CoV-2' named entity 'severe acute respiratory syndrome coronavirus 2' named entity 'antibody' named entity 'rapidly increase' named entity 'IgG' named entity 'ELISA assay' named entity 'RT-PCR' named entity 'RT-PCR' named entity 'SARS-CoV-2' named entity 'IgM' named entity 'SARS-CoV-2' named entity 'viral RNA' named entity 'infection'

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