About: Mechanisms and evidence of vertical transmission of infections in pregnancy including SARS‐CoV‐2

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About: Mechanisms and evidence of vertical transmission of infections in pregnancy including SARS‐CoV‐2 Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Mechanisms and evidence of vertical transmission of infections in pregnancy including SARS‐CoV‐2
Creator	Choolani, Mahesh Huang, Su, L Biswas, A Choolani, M Dimri, Sharma Huang, Ry-J Kanneganti, A Mahyuddin, A Mattar, Cnz Ruby, Yun-Ju Wong, Jlj
source	Medline; PMC
abstract	There remain unanswered questions concerning mother‐to‐child‐transmission (MTCT) of SARS‐CoV‐2. Despite reports of neonatal COVID‐19, SARS‐CoV‐2 has not been consistently isolated in perinatal samples thus, definitive proof of transplacental infection is still lacking. To address these questions, we assessed investigative tools used to confirm maternal‐fetal infection and known protective mechanisms of the placental barrier that prevent transplacental pathogen migration. Forty studies of COVID‐19 pregnancies reviewed suggest a lack of consensus on diagnostic strategy for congenital infection. While RT‐PCR of neonatal swabs was universally performed, a wide range of clinical samples was screened including vaginal secretions (22.5%), amniotic fluid (35%), breast milk (22.5%) and umbilical cord blood. Neonatal COVID‐19 was reported in eight studies, two of which were based on the detection of SARS‐CoV‐2 IgM in neonatal blood. Histological examination demonstrated sparse viral particles, vascular malperfusion and inflammation in the placenta from pregnant women with COVID‐19. The paucity of placental co‐expression of ACE‐2 and TMPRSS2, two receptors involved in cytoplasmic entry of SARS‐CoV‐2, may explain its relative insensitivity to transplacental infection. Viral interactions may utilise membrane receptors other than ACE‐2 thus, tissue susceptibility may be broader than currently known. Further spatial‐temporal studies are needed to determine the true potential for transplacental migration. This article is protected by copyright. All rights reserved.
has issue date	2020-06-12(xsd:dateTime)
bibo:doi	10.1002/pd.5765
bibo:pmid	32529643
has license	no-cc
sha1sum (hex)	16d492b12e64af7b490ce9a472e509e245872dc9
schema:url	https://doi.org/10.1002/pd.5765
resource representing a document's title	Mechanisms and evidence of vertical transmission of infections in pregnancy including SARS‐CoV‐2
has PubMed Central identifier	PMC7307070
has PubMed identifier	32529643
schema:publication	Prenat Diagn
resource representing a document's body	covid:16d492b12e64af7b490ce9a472e509e245872dc9#body_text
is schema:about of	named entity 'copyright' named entity 'virions' named entity 'This' named entity 'MTCT' named entity 'placenta' named entity 'protected by copyright' named entity 'vertical transmission' named entity 'Mother-to-child' named entity 'fetus' named entity 'cytokines' named entity 'TMPRSS2' named entity 'chorionic villus' named entity 'serine protease' named entity 'cell membrane' named entity 'fetal' named entity 'transplacental' named entity 'TMPRSS2' named entity 'natural killer (NK) cells' named entity 'ACE-2' named entity 'SARS-CoV-2' named entity 'protein' named entity 'pathogens' named entity 'SARS-CoV-2' named entity 'pathogens' named entity 'Toll' named entity 'CTs' named entity 'Syncytiotrophoblasts' named entity 'decidual' named entity 'infection control' named entity 'anti-microbial' named entity 'ACE-2' named entity 'gestation' named entity 'pregnancy' named entity 'macrophages' named entity 'placenta' named entity 'uterine cavity' named entity 'breast tissue' named entity 'lung tissue' named entity 'infection' named entity 'SARS-CoV-2' named entity 'stroma' named entity 'TMPRSS2' named entity 'SCTs' named entity 'COVID-19' named entity 'decidual' named entity 'infection' named entity 'placenta' named entity 'placental' named entity 'placenta' named entity 'pathogen' named entity 'villous' named entity 'virion' named entity 'ACE-2' named entity 'SARS-CoV-2' named entity 'fetal' named entity 'NK cell' named entity 'receptor' named entity 'breastfeeding' named entity 'CD8 +' named entity 'macrophages' named entity 'transplacental' named entity 'fetus' named entity 'fetal' named entity 'immunological defence' named entity 'vertical transmission' named entity 'implantation' named entity 'NK cells' named entity 'fetus' named entity 'virus' named entity 'placenta'

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