About: Reactivity of antibodies in human serum with antigens of an enteropathogenic bovine coronavirus

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About: Reactivity of antibodies in human serum with antigens of an enteropathogenic bovine coronavirus Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Reactivity of antibodies in human serum with antigens of an enteropathogenic bovine coronavirus
Creator	Rott, R Storz, J
Source	Medline; PMC
abstract	Antibodies in human serum against an enteropathogenic bovine coronavirus were detected by double immunodiffusion (DID), neutralization of infectivity, indirect immunofluorescence, and immune electron microscopy. Human sera reacting in the DID test neutralized the infectivity of the bovine coronaviruses to indices of 2.5 to > 5. Nineteen of 40 DID-negative, heat-inactivated sera had neutralizing indices of 1 to 3.0. Human serum with neutralizing and DID antibodies produced juxtanuclear and cytoplasmic fluorescence identical to that of bovine immune serum in cells infected with the bovine coronavirus. Antibodies in human and bovine sera interacted with the peplomeres of the bovine coronavirus, matting and bridging them, when present in excess, and facilitated formation of large viral aggregates when present in equivalent concentrations. Complement added to the virus-antibody complexes did not alter specifically the morphology of single, antibody-laden viral particles or viral particles in aggregates. Evidence of the transmission of coronavirus from experimentally inoculated calves to man, with ensuing gastroenteritis, was found by electron microscopic tracing of the coronavirus and its virus-antibody complexes.
has issue date	1981-01-01(xsd:dateTime)
bibo:doi	10.1007/bf02123590
bibo:pmid	6265746
has license	no-cc
sha1sum (hex)	1720d8fe3b882a1e3069906db6bc1cd8ab8033ab
schema:url	https://doi.org/10.1007/bf02123590
resource representing a document's title	Reactivity of antibodies in human serum with antigens of an enteropathogenic bovine coronavirus
has PubMed Central identifier	PMC7086857
has PubMed identifier	6265746
schema:publication	Med Microbiol Immunol
resource representing a document's body	covid:1720d8fe3b882a1e3069906db6bc1cd8ab8033ab#body_text
is schema:about of	named entity 'MEDICAL MICROBIOLOGY' named entity 'aggregates' named entity 'bovine' named entity 'immune' named entity 'sera' named entity 'ANTIBODIES' named entity 'CORONAVIRUS' named entity 'FORMATION' named entity 'AGGREGATES' named entity 'COMPLEXES' named entity 'ELECTRON' named entity 'ALTER' named entity 'INDICES' named entity 'IDENTICAL' named entity 'CALVES' named entity 'VIRAL' named entity 'ITS' named entity 'EQUIVALENT' named entity 'TRANSMISSION' named entity 'HUMAN SERUM' named entity 'BOVINE CORONAVIRUS' named entity 'IMMUNOLOGY' named entity 'HEAT' named entity 'VIRUS' covid:arg/1720d8fe3b882a1e3069906db6bc1cd8ab8033ab named entity 'BOVINE CORONAVIRUS' named entity 'ANTIGENS' named entity 'REACTIVITY' named entity 'INFECTIVITY' named entity 'ANTIBODY' named entity 'TEST' named entity 'INFECTED' named entity 'VIRAL PARTICLES' named entity '1 TO 3' named entity 'ANTIBODIES' named entity 'CELLS' named entity 'COMPLEMENT' named entity 'ADDED' named entity 'SINGLE' named entity 'IMMUNE SERUM' named entity 'MAN' named entity 'DETECTED' named entity 'INDIRECT IMMUNOFLUORESCENCE' named entity 'MATTING' named entity 'INTERACTED' named entity 'MICROSCOPIC' named entity 'PRESENT' named entity 'NINETEEN' named entity 'DID' named entity 'CYTOPLASMIC' named entity 'CONCENTRATIONS' named entity '2.5' named entity 'BOVINE' named entity 'FLUORESCENCE' named entity 'EXCESS' named entity 'INACTIVATED' named entity 'HUMAN' named entity 'CORONAVIRUSES' named entity 'DOUBLE IMMUNODIFFUSION' named entity 'BRIDGING' named entity 'ENTEROPATHOGENIC' named entity 'SERA' named entity 'EVIDENCE OF' named entity 'ELECTRON MICROSCOPY' named entity 'NEGATIVE' named entity 'ENTEROPATHOGENIC' named entity 'HUMAN SERUM' named entity 'GASTROENTERITIS' named entity 'LARGE' named entity 'MORPHOLOGY' named entity 'IMMUNE' named entity 'DID' named entity 'Complement' named entity 'particles' named entity 'neutralization' named entity 'coronavirus' named entity 'indices' named entity 'particles' named entity 'cytoplasmic' named entity 'produced'

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