About: A systematic review of the overlap of fluid biomarkers in delirium and advanced cancer-related syndromes

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About: A systematic review of the overlap of fluid biomarkers in delirium and advanced cancer-related syndromes Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	A systematic review of the overlap of fluid biomarkers in delirium and advanced cancer-related syndromes
Creator	Agar, Meera Amgarth-Duff, Ingrid Caplan, Gideon Hosie, Annmarie
Source	Medline; PMC
abstract	BACKGROUND: Delirium is a serious and distressing neurocognitive disorder of physiological aetiology that is common in advanced cancer. Understanding of delirium pathophysiology is largely hypothetical, with some evidence for involvement of inflammatory systems, neurotransmitter alterations and glucose metabolism. To date, there has been limited empirical consideration of the distinction between delirium pathophysiology and that of the underlying disease, for example, cancer where these mechanisms are also common in advanced cancer syndromes such as pain and fatigue. This systematic review explores biomarker overlap in delirium, specific advanced cancer-related syndromes and prediction of cancer prognosis. METHODS: A systematic review (PROSPERO CRD42017068662) was conducted, using MEDLINE, PubMed, Embase, CINAHL, CENTRAL and Web of Science, to identify body fluid biomarkers in delirium, cancer prognosis and advanced cancer-related syndromes of interest. Studies were excluded if they reported delirium tremens only; did not measure delirium using a validated tool; the sample had less than 75% of participants with advanced cancer; measured tissue, genetic or animal biomarkers, or were conducted post-mortem. Articles were screened for inclusion independently by two authors, and data extraction and an in-depth quality assessment conducted by one author, and checked by two others. RESULTS: The 151 included studies were conducted in diverse settings in 32 countries between 1985 and 2017, involving 28130 participants with a mean age of 69.3 years. Seventy-one studies investigated delirium biomarkers, and 80 studies investigated biomarkers of an advanced cancer-related syndrome or cancer prognosis. Overall, 41 biomarkers were studied in relation to both delirium and either an advanced cancer-related syndrome or prognosis; and of these, 24 biomarkers were positively associated with either delirium or advanced cancer syndromes/prognosis in at least one study. The quality assessment showed large inconsistency in reporting. CONCLUSION: There is considerable overlap in the biomarkers in delirium and advanced cancer-related syndromes. Improving the design of delirium biomarker studies and considering appropriate comparator/controls will help to better understanding the discrete pathophysiology of delirium in the context of co-existing illness.
has issue date	2020-04-22(xsd:dateTime)
bibo:doi	10.1186/s12888-020-02584-2
bibo:pmid	32321448
has license	cc-by
sha1sum (hex)	173fc8d9298f013d791e1e03cde5054994963986
schema:url	https://doi.org/10.1186/s12888-020-02584-2
resource representing a document's title	A systematic review of the overlap of fluid biomarkers in delirium and advanced cancer-related syndromes
has PubMed Central identifier	PMC7178636
has PubMed identifier	32321448
schema:publication	BMC Psychiatry
resource representing a document's body	covid:173fc8d9298f013d791e1e03cde5054994963986#body_text
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