About: Enhancing genetic disease control by selecting for lower host infectivity and susceptibility

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Enhancing genetic disease control by selecting for lower host infectivity and susceptibility
Creator	Tsairidou, Smaragda Anacleto, • Doeschl-Wilson, • Woolliams, J
source	PMC
abstract	Infectious diseases have a huge impact on animal health, production and welfare, and human health. Understanding the role of host genetics in disease spread is important for developing disease control strategies that efficiently reduce infection incidence and risk of epidemics. While heritable variation in disease susceptibility has been targeted in livestock breeding, emerging evidence suggests that there is additional genetic variation in host infectivity, but the potential benefits of including infectivity into selection schemes are currently unknown. A Susceptible-Infected-Recovered epidemiological model incorporating polygenic genetic variation in both susceptibility and infectivity was combined with quantitative genetics selection theory to assess the non-linear impact of genetic selection on field measures of epidemic risk and severity. Response to 20 generations of selection was calculated in large simulated populations, exploring schemes differing in accuracy and intensity. Assuming moderate genetic variation in both traits, 50% selection on susceptibility required seven generations to reduce the basic reproductive number R(0) from 7.64 to the critical threshold of <1, below which epidemics die out. Adding infectivity in the selection objective accelerated the decline towards R(0) < 1, to 3 generations. Our results show that although genetic selection on susceptibility reduces disease risk and prevalence, the additional gain from selection on infectivity accelerates disease eradication and reduces more efficiently the risk of new outbreaks, while it alleviates delays generated by unfavourable correlations. In conclusion, host infectivity was found to be an important trait to target in future genetic studies and breeding schemes, to help reducing the occurrence and impact of epidemics.
has issue date	2019-01-16(xsd:dateTime)
bibo:doi	10.1038/s41437-018-0176-9
bibo:pmid	30651590
has license	cc-by
sha1sum (hex)	174472727bf5b08e9753df6e58b6fd5d7e677926
schema:url	https://doi.org/10.1038/s41437-018-0176-9
resource representing a document's title	Enhancing genetic disease control by selecting for lower host infectivity and susceptibility
has PubMed Central identifier	PMC6781107
has PubMed identifier	30651590
schema:publication	Heredity (Edinb)
resource representing a document's body	covid:174472727bf5b08e9753df6e58b6fd5d7e677926#body_text
is schema:about of	named entity 'generations' named entity 'risk' named entity 'epidemics' named entity 'accelerates' named entity 'epidemics' named entity 'Infectious diseases' named entity 'impact' named entity 'number' named entity 'control' named entity 'MEASURES' named entity 'TARGET' named entity 'RISK OF' named entity 'REDUCE' named entity 'ACCELERATED' named entity 'INFECTIOUS DISEASES' named entity 'HOST' named entity 'EPIDEMICS' named entity 'RESPONSE TO' named entity 'DISEASE CONTROL' named entity 'INCLUDING' named entity 'REPRODUCTIVE' named entity 'GENERATIONS' named entity 'RISK' named entity 'HUGE' named entity 'ANIMAL HEALTH' named entity 'PRODUCTION' named entity 'QUANTITATIVE GENETICS' named entity 'CONCLUSION' named entity 'INFECTED' named entity 'DISEASE ERADICATION' named entity 'TRAITS' named entity 'LARGE' named entity 'SUSCEPTIBLE' named entity 'CALCULATED' named entity 'BENEFITS' named entity 'INTENSITY' named entity 'selection' named entity 'infectivity' named entity 'large' named entity 'While' named entity 'polygenic' named entity 'die' named entity 'disease' named entity 'threshold' named entity 'targeted' named entity 'theory' named entity 'selection' named entity 'selection' named entity 'susceptibility' named entity 'strategies' named entity 'genetic' named entity 'heritable variation' named entity 'human health' named entity 'non-linear' named entity 'epidemic' named entity 'animal health' named entity '3 generations' named entity 'epidemics' named entity 'infection' named entity 'genetic selection' named entity 'phenotype' named entity 'infectivity' named entity 'statistical inference' named entity 'infectivity' named entity 'random sampling' named entity 'infectivity' named entity 'genetic effects' named entity 'random allocation' named entity 'infectivity' named entity 'artificial insemination' named entity 'infectivity' named entity 'genetic effects' named entity 'infection' named entity 'genetic effects' named entity 'exponential distribution' named entity 'genomic data' named entity 'bovine tuberculosis' named entity 'genetic selection'

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