About: Surgical Resection and Prognostic Analysis of 142 Cases of Hilar Cholangiocarcinoma

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Surgical Resection and Prognostic Analysis of 142 Cases of Hilar Cholangiocarcinoma
Creator	Zhu, Jie Wang, Jie Jiang, Hai He, Chuanchao Xiao, Zhiyu Xu, Junyao Yu, Zhimin
source	PMC
abstract	Surgical resection for hilar cholangiocarcinoma is the only curative option, but low resectability rate and poor survival outcomes remain a challenge. This study was to assess the surgical resection for hilar cholangiocarcinoma and analyze the prognostic factors influencing postoperative survival. One hundred forty-two patients with hilar cholangiocarcinoma who underwent surgical resection between January 2006 and December 2014 were analyzed retrospectively based on clinicopathological and demographic data. Univariate and multivariate analysis against outcome were employed to identify potential factors affecting prognosis. Ninety-five patients were performed with R0 resection with median survival time of 22 months; whereas, 47 patients underwent non-R0 resection (R1 = 20, R2 = 27) with that of 10 months. Of these 95 patients, 19 underwent concomitant with vascular resection and reconstruction and 2 patients underwent pancreaticoduodenectomy. 64.8% patients (n = 92) underwent combined with hepatectomy. The one-year, three-year, and five-year survival rates after R0 resection were 76.3, 27.8, 11.3%, respectively, which was significantly better than that after non-curative resection (P = 0.000). Multivariate analysis revealed that non-curative resection (RR: 2.414, 95% CI 1.586–3.676, P = 0.000), pathological differentiation (P = 0.015) and preoperative serum total bilirubin above 10 mg/dL (RR: 1.844, 95% CI 1.235–2.752, P = 0.003) were independent prognostic factors. Aggressive curative resection remains to be the optimal option for hilar cholangiocarcinoma. Non-curative resection, pathological differentiation, and preoperative serum total bilirubin above 10 mg/ dL were associated with dismal prognosis.
has issue date	2017-01-07(xsd:dateTime)
bibo:doi	10.1007/s12262-016-1581-z
bibo:pmid	32288384
has license	no-cc
sha1sum (hex)	17480e9fe10045032fafbab159a174b0d5a6117b
schema:url	https://doi.org/10.1007/s12262-016-1581-z
resource representing a document's title	Surgical Resection and Prognostic Analysis of 142 Cases of Hilar Cholangiocarcinoma
has PubMed Central identifier	PMC7102051
has PubMed identifier	32288384
schema:publication	Indian J Surg
resource representing a document's body	covid:17480e9fe10045032fafbab159a174b0d5a6117b#body_text
is schema:about of	named entity 'multivariate analysis' named entity 'hilar' named entity 'resection' named entity 'Cholangiocarcinoma' covid:arg/17480e9fe10045032fafbab159a174b0d5a6117b named entity 'serum' named entity 'resection' named entity 'cholangiocarcinoma' named entity 'factors' named entity 'patients' named entity 'data' named entity 'Multivariate analysis' named entity 'Univariate' named entity 'pancreaticoduodenectomy' named entity 'hepatectomy' named entity 'Surgical resection' named entity 'time' named entity 'performed' named entity 'patients' named entity 'Resection' named entity 'pancreaticoduodenectomy' named entity 'serum' named entity 'surgical resection' named entity 'Surgical resection' named entity 'prognosis' named entity 'prognosis' named entity 'cholangiocarcinoma' named entity 'serum' named entity 'hilar' named entity 'hilar' named entity 'Prognostic' named entity 'tumor' named entity 'μmol/L' named entity 'significant difference' named entity 'morbidity' named entity '5-year survival' named entity 'tumor' named entity 'hepatic failure' named entity 'computed tomography' named entity 'median survival time' named entity 'type II' named entity 'PVE' named entity 'prognosis' named entity 'tumor' named entity 'bile duct' named entity 'hepatectomy' named entity 'Pancreaticoduodenectomy' named entity 'thrombi' named entity 'SPSS' named entity 'Percutaneous' named entity 'thrombi' named entity 'contraindication' named entity 'cholangitis' named entity 'multivariate analysis' named entity 'CA19-9' named entity 'risk factors' named entity 'statistical analyses' named entity 'median survival time' named entity 'median survival time' named entity 'portal vein' named entity 'thrombi' named entity 'end-to-end anastomosis' named entity 'Student's t test' named entity 'hepatectomy' named entity 'median survival time' named entity 'palliative' named entity 'anastomosis' named entity 'hepatectomy' named entity 'liver failure' named entity 'lesion' named entity 'hepatic artery' named entity 'total bilirubin' named entity 'prospective studies' named entity 'serum' named entity '5-year survival rate'

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